Frendic (SR-100) 20 Capsules

Venlafaxine 100mg capsules primarily exert their therapeutic effects through selective inhibition of neuronal serotonin and norepinephrine reuptake. This mechanism is achieved by blocking the serotonin transporter (SERT) and norepinephrine transporter (NET), which are responsible for the reabsorption of these neurotransmitters into the presynaptic neuron. By inhibiting these transporters, venlafaxine increases the availability of serotonin and norepinephrine in the synaptic cleft, enhancing neurotransmission. This elevation in serotonin and norepinephrine levels is believed to contribute to the improvement of mood and alleviation of symptoms associated with depression and certain anxiety disorders. Additionally, venlafaxine exhibits weak effects on dopamine reuptake, which may also play a role in its overall mechanism of action.

Serotonin-norepinephrine reuptake inhibitor (SNRI)

Capsule

The following are the uses of Venlafaxine 100mg Capsule:

• Used for treating major depressive disorder in adults, helping to alleviate symptoms like persistent sadness and loss of interest.
• Used for managing generalized anxiety disorder, reducing excessive worry and anxiety that impacts daily life.
• Used to treat panic disorder, aiming to decrease the frequency and intensity of panic attacks.
• Used in certain cases of social anxiety disorder to reduce social inhibition and related distress.
• Can be utilized for managing pain associated with certain chronic conditions, providing relief.
• Used to alleviate hot flashes and mood symptoms during menopause, improving quality of life.
• May be prescribed off-label for other anxiety-related conditions under professional guidance.
• Used to support long-term management of mental health conditions, promoting overall well-being.

In the case of an overdose of Venlafaxine 100mg Capsules, it is important to recognize the potential severity of this situation. Symptoms may include rapid heartbeat, dizziness, and even seizures. Promptly seek medical assistance and inform healthcare professionals about the overdose. They will provide necessary guidance and care to manage the situation effectively. Time is crucial in such cases, so act swiftly to ensure the best possible outcome.

In the case of a missed dose of Venlafaxine 100mg Capsule, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is recommended to skip the missed dose and continue with your regular dosing schedule. Avoid taking extra medication to make up for a missed dose, as this can increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen. It is generally advised to take the medication at the same time each day to maintain consistent levels in your body.

To take Venlafaxine 100mg Capsule, swallow the capsule whole with a full glass of water, preferably at the same time each day, as directed by your healthcare provider, without crushing or chewing the capsule.

Here are the conditions and situations when Venlafaxine 100mg Capsule should not be taken:

• Do not take if you are allergic to Venlafaxine or similar medications like serotonin-norepinephrine reuptake inhibitors (SNRIs) or any of its ingredients.
• Avoid if you have narrow-angle glaucoma.
• Do not use if you are currently taking or have taken a Monoamine Oxidase Inhibitor (MAOI) in the last 14 days.
• Not suitable for individuals with uncontrolled high blood pressure (hypertension).
• Contraindicated in patients with a history of bleeding disorders or conditions that increase the risk of bleeding.
• Should not be taken if you have a history of liver or kidney problems.

The side effects of Venlafaxine 100mg Capsule may include:

• Nausea and vomiting
• Dry mouth
• Dizziness and lightheadedness
• Headache
• Insomnia or sleep disturbances
• Constipation or diarrhea
• Excessive sweating
• Sexual dysfunction

Following are the precautions and warnings for Venlafaxine 100mg Capsule:

• Do not start or stop taking this medication without consulting your doctor, as sudden discontinuation may lead to withdrawal symptoms.
• Patients with a history of suicidal thoughts or attempts should be closely monitored, especially at the beginning of treatment.
• This medication may increase blood pressure, so regular monitoring is necessary, especially in patients with hypertension.
• It can cause a potentially life-threatening condition called serotonin syndrome, especially when combined with other serotonergic drugs. Seek medical attention if symptoms such as agitation, hallucinations, or rapid heart rate occur.
• Venlafaxine may cause an increase in cholesterol levels, so monitoring is recommended during long-term use.
• Caution is advised in patients with a history of seizures, as this medication may lower the seizure threshold.
• Pregnant or breastfeeding women should consult their doctor before taking Venlafaxine, as it may have potential risks for the fetus or infant.
• Avoid alcohol consumption while taking this medication, as it can increase the risk of adverse effects.

Following are the drug interactions for Venlafaxine 100mg Capsule:

• Serotonin-norepinephrine reuptake inhibitors (SNRIs) like duloxetine or desvenlafaxine can lead to serotonin syndrome when combined, resulting in symptoms like agitation, confusion, and gastrointestinal issues.
• Monoamine oxidase inhibitors (MAOIs) such as phenelzine or tranylcypromine are contraindicated due to the risk of elevated blood pressure and serotonin syndrome.
• Venlafaxine may enhance the effects of anticoagulants like warfarin, necessitating close monitoring of bleeding risks.
• Central nervous system depressants (e.g., benzodiazepines, alcohol) can cause increased sedation and impaired cognitive function when used with venlafaxine.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen may elevate the risk of gastrointestinal bleeding.
• Venlafaxine can raise blood levels of certain anticonvulsants and antipsychotics, potentially increasing side effects.
• Drugs that affect liver enzymes may alter venlafaxine metabolism, requiring dosage adjustments.

Following are the food interactions for Venlafaxine 100mg Capsule:

• Avoid consuming alcohol with Venlafaxine as it can increase the risk of side effects, including drowsiness and dizziness.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Venlafaxine, leading to increased drug levels in the body.
• Caffeine intake should be monitored as Venlafaxine may enhance its effects, causing increased heart rate and blood pressure.
• Foods high in tyramine, like aged cheeses, cured meats, and fermented foods, should be limited as Venlafaxine can potentially interact, leading to elevated blood pressure.
• Avoid high-fat meals as they may affect the absorption of Venlafaxine, potentially altering its effectiveness.
• Herbal supplements like St. John's Wort should be avoided as they can interact with Venlafaxine, affecting its efficacy and increasing the risk of side effects.
• Maintain a balanced diet to support overall well-being, ensuring stable blood sugar levels, which can influence mood and energy.
• Always consult your healthcare provider for personalized advice on dietary considerations while taking Venlafaxine.

Venlafaxine 100mg Capsules should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area. Keep the capsules in their original packaging, ensuring the container is tightly sealed to maintain their integrity. It is crucial to store them at room temperature, away from excessive heat, direct sunlight, or moisture, as these conditions can degrade the medication. Always check the expiration date on the packaging, and do not use the capsules beyond this date. When disposing of unused or expired capsules, do not flush them down the toilet or throw them into the trash. Instead, consult your pharmacist or local waste management guidelines for safe disposal options to protect the environment and prevent misuse. Keep the medication out of children's reach to ensure their safety.

Following are the quick tips for Venlafaxine 100mg Capsule:

• Take the capsule at the same time each day as prescribed by your doctor.
• Swallow the capsule whole with a full glass of water, do not crush or chew.
• You can take it with or without food, but be consistent with your choice.
• Avoid alcohol consumption as it may intensify side effects.
• Do not stop taking the medication without consulting your doctor.
• If you experience any worrying side effects, contact your healthcare provider immediately.
• Store the capsules in a cool, dry place, away from direct sunlight.