FYMOTIL (LOMOTIL)

Diphenoxylate is the primary active ingredient in the tablet, and it works by acting on the opioid receptors in the gastrointestinal tract. Specifically, it binds to the mu-opioid receptors, which leads to a reduction in intestinal motility. This binding activates the inhibitory G-proteins, resulting in decreased cyclic adenosine monophosphate (cAMP) production. Consequently, there is a reduction in the entry of calcium ions into the intestinal smooth muscle cells, causing relaxation and decreased peristalsis. Atropine, in this combination, is present in small amounts and acts as an anticholinergic agent. It helps to reduce the secretions in the intestines and further contributes to the antidiarrheal effect by slowing down intestinal contractions.

Antidiarrheal, Anticholinergic

Tablet

The following are the uses of Diphenoxylate 2.5mg, Atropine 0.025mg Tablet:

• Used for treating severe diarrhea
• Used to control acute and chronic diarrhea associated with inflammatory bowel diseases
• Used to manage gastrointestinal symptoms like abdominal pain and cramping
• Used to reduce the frequency of bowel movements
• Used to alleviate traveler's diarrhea
• Used to manage diarrhea caused by gastrointestinal infections
• Used as a supportive therapy during gastrointestinal recovery

In the case of an overdose of Diphenoxylate 2.5mg and Atropine 0.025mg Tablets, symptoms may include severe constipation, difficulty breathing, and a rapid heart rate. The overdose can lead to a dangerous condition called ileus, where the intestines stop functioning. Other signs include pinpoint pupils, dry mouth, and confusion. Prompt medical intervention is necessary, as treatment may involve gastric lavage, administration of activated charcoal, and supportive care to manage the symptoms and prevent further complications.

In the case of a missed dose of Diphenoxylate 2.5mg, Atropine 0.025mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your dosing schedule. It is recommended to set reminders or use pill organizers to help you remember to take your medication as prescribed.

To take the Diphenoxylate 2.5mg, Atropine 0.025mg Tablet, place the tablet on your tongue and allow it to dissolve, following the dosage instructions provided by your healthcare provider, typically taken every 3 to 4 hours as needed, without chewing or crushing the tablet.

Following are the conditions or situations when Diphenoxylate 2.5mg, Atropine 0.025mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Diphenoxylate, Atropine, or any of its components.
• Contraindicated in patients with acute intestinal conditions like ulcerative colitis, appendicitis, or intestinal obstruction.
• Not suitable for individuals with severe diarrhea caused by antibiotics or pseudomembranous colitis.
• Should not be used in patients with a history of liver or kidney disease.
• Contraindicated in individuals with a history of hypersensitivity reactions to belladonna alkaloids.
• Not recommended for children under 2 years of age.
• Should be avoided in patients with severe dehydration or those who are unable to maintain adequate fluid intake.
• Not suitable for individuals with a history of liver disorders, including hepatitis or jaundice.

The side effects of Diphenoxylate 2.5mg, Atropine 0.025mg Tablet may include:

• Constipation
• Nausea and vomiting
• Dizziness
• Dry mouth
• Blurred vision or dilated pupils
• Difficulty urinating
• Skin rash or itching
• Drowsiness or sedation

Following are the precautions and warnings for Diphenoxylate 2.5mg, Atropine 0.025mg Tablet:

• This medication should not be used in patients with a known allergy or hypersensitivity to Diphenoxylate, Atropine, or any of the tablet's components.
• May cause drowsiness or dizziness, so patients should not drive or operate heavy machinery until they know how the medication affects them.
• Caution is advised for patients with a history of liver or kidney disease, as it may require dosage adjustments.
• Elderly patients may be more sensitive to the side effects, especially constipation and drowsiness.
• Avoid alcohol consumption while taking this medication, as it can increase the risk of side effects.
• Not recommended for children under 6 years old unless prescribed by a doctor.
• Consult a healthcare professional if you have a history of gastrointestinal problems, as this medication may affect bowel function.

Following are the drug interactions for Diphenoxylate 2.5mg, Atropine 0.025mg Tablet:

• Alcohol and other central nervous system (CNS) depressants (e.g., opioids, benzodiazepines) can enhance sedation and respiratory depression, leading to serious adverse effects.
• Avoid using with other anticholinergic medications as it may increase the risk of side effects like dry mouth, blurred vision, and urinary retention.
• Drugs that inhibit CYP2D6 enzyme (e.g., fluoxetine, paroxetine) may decrease the metabolism of diphenoxylate, leading to increased side effects.
• Concomitant use with monoamine oxidase inhibitors (MAOIs) is contraindicated due to the risk of serious adverse reactions.
• Diphenoxylate may decrease the absorption of other medications, particularly those requiring an acidic stomach environment for absorption.
• Anticonvulsants such as phenytoin and carbamazepine may decrease the effectiveness of diphenoxylate by increasing its metabolism.
• Caution with drugs that prolong QT interval, as atropine may also prolong QT interval, increasing the risk of cardiac arrhythmias.

Following are the food interactions for Diphenoxylate 2.5mg, Atropine 0.025mg Tablet:

• Grapefruit and grapefruit juice should be avoided as they may inhibit the metabolism of the medication, potentially leading to increased side effects.
• Alcohol consumption should be limited as it can enhance the sedative effects of Diphenoxylate, causing dizziness and drowsiness.
• Avoid consuming large amounts of high-fat meals as they may delay the absorption of the medication.
• Caffeine-containing beverages like coffee and energy drinks may increase the stimulant effects of the medication and should be consumed in moderation.
• Avoid natural licorice as it can interact with the medication, potentially affecting blood pressure and heart rate.
• Stay hydrated and maintain a balanced diet to support overall health while taking this medication.
• Consult your healthcare provider for specific dietary recommendations based on your medical condition.
• No significant food interactions are reported with Atropine, but it's essential to follow the prescribed dosage instructions.

Diphenoxylate 2.5mg, Atropine 0.025mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, ensuring they are out of the reach of children and pets. It is recommended to keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to moisture. Avoid storing them in bathrooms or kitchens, as humidity and temperature fluctuations can affect the medication. When disposing of unused or expired tablets, do not flush them down the toilet or throw them into the trash. Instead, follow local guidelines for pharmaceutical waste disposal, which may involve returning them to a pharmacy or a designated collection point for safe and environmentally friendly disposal. Proper disposal ensures the protection of both the environment and public health.

Following are the quick tips for Diphenoxylate 2.5mg, Atropine 0.025mg Tablet:

• Consult a doctor or pharmacist for personalized advice on taking this medication.
• Swallow the tablet whole; do not crush, chew, or break it.
• Take the tablet with a full glass of water to ensure proper swallowing.
• Maintain a consistent daily routine for taking the medication as directed.
• Do not double the dose to make up for a missed one; take it as soon as you remember.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.
• Inform your doctor about any other medications you are taking to prevent drug interactions.
• Do not share this medication with others, even if their symptoms are similar.