GASTROGRAFIN 100ML ORAL LIQUID.

Meglumine amidotrizoate and Sodium amidotrizoate are contrast agents used in medical imaging. Their mechanism of action involves replacing the hydrogen atoms in water molecules with the contrast agent's iodine atoms, which increases the X-ray absorption of tissues. This enhanced X-ray absorption allows for better visualization and differentiation of tissues and structures during radiographic procedures, aiding in the diagnosis and evaluation of various medical conditions.

Iodinated contrast media

Suspension

The following are the uses of meglumine amidotrizoate, Sodium amidotrizoate Syrup/Suspension:

• Used for contrast enhancement in radiographic studies of the gastrointestinal tract, allowing for better visualization of the organs and any potential abnormalities.
• Used for detecting gastrointestinal tract abnormalities such as ulcers, tumors, or inflammation.
• Used for assessing gastrointestinal motility and identifying areas of obstruction or delayed transit.
• Used for evaluating the extent and severity of gastrointestinal diseases, aiding in diagnosis and treatment planning.
• Used for guiding therapeutic interventions, such as endoscopic procedures or surgical planning.
• Used for monitoring the progression or regression of gastrointestinal conditions over time.
• Used for distinguishing between benign and malignant gastrointestinal lesions, aiding in cancer detection.

In the case of an overdose of meglumine amidotrizoate or Sodium amidotrizoate Syrup/Suspension, prompt medical attention is necessary. Symptoms may include nausea, vomiting, and diarrhea, with potential severe effects on the kidneys and liver. Seek emergency care, and provide healthcare professionals with information regarding the ingested substance, estimated amount, and timing of the overdose to ensure appropriate treatment. Timely intervention is vital to prevent potential complications.

In the case of a missed dose of meglumine amidotrizoate or Sodium amidotrizoate Syrup/Suspension, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or asking someone to help you remember.

To administer meglumine amidotrizoate and Sodium amidotrizoate syrup/suspension, shake the bottle well, measure the prescribed dose with an accurate measuring device, and take it orally as directed by your healthcare provider, with or without food, following the recommended dosage instructions.

Following are the conditions/situations when meglumine amidotrizoate, Sodium amidotrizoate Syrup/Suspension should not be used:

• Allergy or hypersensitivity to meglumine, Sodium amidotrizoate or any other ingredients in the formulation.
• Patients with a history of severe or immediate allergic reactions to contrast media should not take this medication.
• Not recommended for individuals with severe kidney disease or impaired kidney function.
• Contraindicated in patients with a history of bronchial asthma or severe respiratory conditions.
• Should not be used in patients with a history of thyroid disorders or recent thyroid surgery.
• Not suitable for individuals with a history of cardiovascular diseases, especially heart attack or stroke.
• Contraindicated in patients with pheochromocytoma.
• Should not be used in patients with multiple myeloma.
• Not recommended for individuals with a history of gastrointestinal obstructions or severe gastrointestinal conditions.

The side effects of meglumine amidotrizoate and Sodium amidotrizoate Syrup/Suspension may include:

• Nausea and vomiting
• Diarrhea
• Constipation
• Abdominal pain or discomfort
• Skin rashes or itching
• Allergic reactions such as hives, swelling, or difficulty breathing
• Changes in blood pressure (either increase or decrease)
• Renal impairment or damage, especially with prolonged or repeated use

Following are the precautions and warnings for meglumine amidotrizoate, Sodium amidotrizoate Syrup/Suspension:

• This medication should be used with caution in patients with a history of allergic reactions to iodine-based contrast media or any other allergies. Anaphylactic reactions may occur.
• Not recommended for use in neonates and infants due to the risk of severe adverse effects, including nephrotoxicity and neurotoxicity.
• Patients with kidney disease or impaired renal function should be closely monitored, as this medication can worsen kidney function.
• Dehydration is a risk factor, and patients should maintain adequate hydration before and after the procedure.
• Elderly patients may be more susceptible to adverse effects, particularly kidney-related issues.
• Patients with a history of thyroid disease should be monitored, as this medication may interfere with thyroid function.
• It is important to inform your healthcare provider about all medications you are taking, as drug interactions can occur.
• Meglumine amidotrizoate, Sodium amidotrizoate should only be used when clearly needed during pregnancy and breastfeeding, as it can cross the placenta and is present in breast milk.

Following are the drug interactions for meglumine amidotrizoate, Sodium amidotrizoate Syrup/Suspension:

• Lithium, May increase lithium levels, potentially leading to lithium toxicity.
• Anticoagulants (e.g., warfarin), May increase the risk of bleeding by altering platelet function.
• Anticonvulsants (e.g., phenytoin), May decrease the effectiveness of anticonvulsant medications.
• Antidiabetic drugs (e.g., insulin), May alter blood glucose control, requiring close monitoring.
• Methotrexate, Potential increase in methotrexate toxicity due to reduced renal clearance.
• Nonsteroidal anti-inflammatory drugs (NSAIDs), May increase the risk of kidney damage, especially with prolonged use.
• Diuretics, May enhance the nephrotoxic effects of amidotrizoates, requiring careful monitoring of kidney function.

Following are the food interactions for Meglumine Amidotrizoate and Sodium Amidotrizoate Syrup/Suspension:

• Avoid consuming high-fat meals before and after the procedure, as fatty foods can affect the absorption and distribution of the contrast media, potentially altering the diagnostic results.
• Refrain from consuming foods or drinks with high sugar content, as this medication can increase blood sugar levels.
• Grapefruit and grapefruit juice should be avoided as they may interfere with the metabolism of the drug, leading to increased blood levels and potential side effects.
• Alcohol should be limited or avoided, as it can interact with the medication and increase the risk of dehydration and kidney-related side effects.
• Stay well-hydrated by drinking plenty of fluids, preferably water, before and after the procedure to help eliminate the contrast media from the body.
• Avoid caffeine-rich beverages like coffee and tea, as they can impact blood flow and potentially affect the diagnostic procedure.
• Certain herbal supplements, especially those affecting kidney function, should be discontinued temporarily, as they might interact with the medication's elimination process.
• Consult your healthcare provider for specific dietary instructions, especially if you have pre-existing medical conditions like diabetes or kidney disease.

Meglumine amidotrizoate and Sodium amidotrizoate Syrup/Suspension should be stored in a controlled environment, preferably in a cool and dry place, away from direct sunlight and moisture. The medication container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial to store it away from heat sources to preserve its effectiveness. Always adhere to the expiration date indicated on the packaging, and when the product is no longer needed, proper disposal is essential. Avoid disposing of it in sinks or toilets; instead, seek guidance from a pharmacist or healthcare professional for safe disposal methods. Ensure that the medication is kept out of children's reach to prevent accidental consumption.

Following are the quick tips for meglumine amidotrizoate and Sodium amidotrizoate Syrup/Suspension:

• Always consult your doctor or radiologist before taking the medication.
• Follow the prescribed dosage and duration provided by your healthcare professional.
• Ensure you are well-hydrated before and after the procedure.
• Inform your doctor about any allergies or medical conditions you have.
• Avoid driving or operating heavy machinery until you know how the medication affects you.
• Report any unusual symptoms or side effects to your healthcare provider immediately.
• Store the medication out of reach of children and away from direct sunlight.