Gempid (600mg) 20 Tablets

Gemfibrozil, the active ingredient in the 600mg tablet, primarily exerts its lipid-modifying effects by activating peroxisome proliferator-activated receptor alpha (PPAR-alpha). This activation results in an upregulation of lipoprotein lipase (LPL) activity, which plays a crucial role in the metabolism of triglyceride-rich particles. By stimulating LPL, gemfibrozil enhances the breakdown of triglycerides, leading to reduced levels of very-low-density lipoproteins (VLDL) and low-density lipoproteins (LDL) in the bloodstream. Simultaneously, the drug inhibits hepatic triglyceride synthesis, further contributing to decreased VLDL production and secretion. These mechanisms collectively lead to a reduction in plasma triglyceride and LDL cholesterol levels, while also increasing high-density lipoprotein (HDL) cholesterol levels, thereby improving the overall lipid profile.

Gemfibrozil 600mg

Fibrate lipid-lowering agent.

Tablet

The following are the uses of Gemfibrozil 600mg Tablet:

• Used for lowering high levels of cholesterol and triglycerides in the blood
• Used for reducing the risk of developing heart disease and pancreatitis related to high triglyceride levels
• Used to treat hyperlipidemia, a condition where there is an imbalance of fats in the blood
• Used to slow down the formation of fatty deposits in the blood vessels, reducing the risk of blockages
• Used for improving overall lipid profile and reducing the risk of cardiovascular events
• Used for managing lipid disorders when lifestyle changes alone are not sufficient
• Used to help prevent the progression of atherosclerosis, a hardening of the arteries
• Used as an adjunct to diet and exercise to achieve optimal lipid control

To be taken as per doctor's prescription

In the case of an overdose of Gemfibrozil 600mg Tablets, the severity of symptoms can vary. Common signs may include gastrointestinal issues like nausea, vomiting, and stomach pain. More serious effects could lead to liver damage, muscle pain, and weakness. It is important to recognize these symptoms and seek medical advice promptly if an overdose is suspected, as early intervention can help manage and minimize potential health risks associated with excessive Gemfibrozil intake.

In the case of a missed dose of Gemfibrozil 600mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, inform your healthcare provider, as they may provide guidance on how to adjust your dosing schedule to ensure optimal treatment.

To take Gemfibrozil 600mg Tablet, swallow the tablet whole with a full glass of water, preferably during a meal or as directed by your healthcare professional, typically once or twice a day, following the prescribed dosage and treatment duration provided by your doctor.

Following are the conditions when Gemfibrozil 600mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Gemfibrozil or any of its ingredients.
• Not suitable for patients with severe kidney disease or those on dialysis.
• Contraindicated in patients with gallbladder disease or gallstones.
• Should not be used in individuals with severe liver impairment or active liver disease.
• Not recommended for those with pancreatitis or a history of pancreatitis.
• Contraindicated during pregnancy and breastfeeding.
• Avoid using this medication if you have a rare condition called hemolytic anemia.
• Do not use if you have recently had surgery or are scheduled for surgery.

The side effects of Gemfibrozil 600mg Tablet may include:

• Stomach pain or upset
• Diarrhea
• Nausea and vomiting
• Loss of appetite
• Fatigue and weakness
• Dizziness
• Skin rash or itching
• Gallstones

Following are the precautions and warnings for Gemfibrozil 600mg Tablet:

• Do not take this medication if you are allergic to gemfibrozil or similar medications.
• Patients with kidney or liver disease must exercise caution and inform their doctor, as dosage adjustments may be necessary.
• This medication may cause muscle-related side effects, and regular monitoring of muscle enzymes is recommended, especially during the initial months of treatment.
• Avoid alcohol consumption while taking Gemfibrozil as it may increase the risk of liver-related side effects.
• Inform your doctor if you have a history of gallbladder disease or pancreatitis before starting this medication.
• Elderly patients may be more susceptible to muscle and liver-related side effects, and close monitoring is advised.
• Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as Gemfibrozil may have potential risks during these periods.

Following are the drug interactions for Gemfibrozil 600mg Tablet:

• Gemfibrozil may increase the risk of muscle-related side effects when used with statins like simvastatin or atorvastatin. Close monitoring is required.
• Taking Gemfibrozil with fibrates like fenofibrate may increase the risk of rhabdomyolysis, a serious muscle condition.
• The use of Gemfibrozil with warfarin or other anticoagulants can enhance the anticoagulant effect, requiring careful monitoring of INR (International Normalized Ratio).
• Gemfibrozil may decrease the effectiveness of oral contraceptives, requiring an alternative or additional contraceptive method.
• Caution is advised when combining Gemfibrozil with immunosuppressants like cyclosporine, as it may increase cyclosporine levels.
• It can interact with ezetimibe, potentially increasing the risk of myopathy and rhabdomyolysis.
• Gemfibrozil may increase the plasma concentrations of repaglinide, requiring dosage adjustments.

Following are the food interactions for Gemfibrozil 600mg Tablet:

• Avoid excessive alcohol consumption while taking this medication as it may increase the risk of liver-related adverse effects.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Gemfibrozil, potentially leading to increased drug levels in the body.
• High-fat meals may slightly decrease the absorption of Gemfibrozil, but this effect is generally not clinically significant.
• Avoid consuming large amounts of saturated fats and cholesterol-rich foods, as Gemfibrozil is used to lower cholesterol levels and dietary control is important for its effectiveness.
• Avoid eating large amounts of fatty fish or fish oil supplements, as they may increase the risk of bleeding when combined with Gemfibrozil.
• Maintain a balanced diet as recommended by your healthcare provider to support the medication's cholesterol-lowering effects.
• Follow the dietary plan provided by your doctor or dietitian to ensure the medication's optimal effectiveness.
• Consult your healthcare provider for personalized advice on dietary restrictions or modifications during Gemfibrozil therapy.

Gemfibrozil 600mg Tablets should be stored in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. It is crucial to keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent contamination. Avoid exposing the medication to high temperatures or storing it in the bathroom, as humidity and heat can degrade its quality. Proper disposal is essential; do not flush or pour the medication down the drain. Consult your pharmacist or healthcare professional for appropriate disposal methods to ensure environmental safety. Keep the tablets out of children's reach to prevent accidental consumption, which may be harmful. Always adhere to local guidelines for pharmaceutical waste management when disposing of this medication.

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Following are the quick tips for Gemfibrozil 600mg Tablet:

• Take the tablet as directed by your doctor, typically twice a day with meals.
• Swallow the tablet whole; do not crush or chew it for optimal absorption.
• Maintain a consistent schedule for taking the medication for best results.
• Avoid consuming large amounts of alcohol while on this medication.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Regularly monitor your blood sugar levels if you have diabetes while on this medication.
• Store the tablets at room temperature, away from moisture and heat.