Gen-M (120mg) 1 Injection

Artesunate 120mg injection primarily acts by interfering with the parasite's mitochondrial membrane, specifically targeting the Plasmodium species responsible for malaria. It triggers the production of free radicals, which exert cytotoxic effects on the parasites, leading to their destruction. The artesunate molecule undergoes metabolic conversion, generating reactive oxygen species that disrupt the parasite's cellular functions, particularly affecting the parasite's ability to metabolize heme, a crucial process for its survival. This mechanism effectively combats the parasite, contributing to the resolution of malaria symptoms.

Artesunate 120mg

Antimalarial medication

Injection

The following are the uses of Artesunate 120mg injection:

• Used for treating severe malaria, especially in adults with high parasite load.
• Used for rapid reduction of malaria parasites in the blood.
• Used as an emergency treatment for severe malaria when oral treatment is not feasible.
• Used to manage cerebral malaria and prevent associated complications.
• Used in combination with other antimalarials for improved efficacy.
• Used to reduce the risk of treatment failure and drug resistance.
• Used for its fast-acting properties to stabilize critically ill patients.
• Used in life-threatening cases, providing rapid clinical improvement.

In the case of an overdose of Artesunate 120mg injection, prompt medical attention is necessary. The severity of symptoms may vary, but common effects include an increased risk of severe allergic reactions, potential liver damage, and an elevated heart rate. Seek emergency care immediately if an overdose is suspected, as early intervention can help mitigate these adverse effects and ensure appropriate treatment to manage any complications that may arise from the excessive dosage.

In the case of a missed dose of Artesunate 120mg injection, it is crucial to take immediate action. If you realize you've missed a dose, administer the injection as soon as possible, but only if the next scheduled dose is not too close. Never double the dose to make up for a missed one. If it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. It is essential to maintain the medication's effectiveness by adhering to the prescribed timing as closely as possible. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

To administer Artesunate 120mg injection, reconstitute the powder with the provided sterile diluent, gently swirl to dissolve, and inject the entire content intramuscularly or intravenously as directed by your healthcare professional.

Here are the conditions or situations when Artesunate 120mg injection should not be administered:

• Should not be used in individuals with a known allergy to Artesunate or other artemisinin-based compounds.
• Contraindicated in patients with severe liver disease or impaired liver function.
• Not recommended for patients with severe kidney disease or those undergoing dialysis.
• Should not be used in individuals with a history of severe cardiovascular disorders or arrhythmias.
• Contraindicated during the first trimester of pregnancy due to potential risks to the fetus.
• Should not be administered to breastfeeding women, as it may pass into breast milk.
• Not suitable for individuals with a history of severe allergic reactions to other medications.
• Should be avoided in patients with a known deficiency of an enzyme called glucose-6-phosphate dehydrogenase (G6PD).
• Contraindicated in patients with a history of severe neurological disorders.

The side effects of Artesunate 120mg injection may include:

• Nausea and vomiting.
• Dizziness or a spinning sensation.
• Fever and chills.
• Injection site reactions such as pain, swelling, or redness.
• Allergic reactions, including rash, itching, and difficulty breathing.
• Abnormal liver function tests.
• Temporary hair loss.
• Unusual or unpleasant taste in the mouth.

Following are the precautions and warnings for Artesunate 120mg injection:

• Not recommended for individuals with known hypersensitivity or allergy to Artesunate or any of its excipients.
• Close monitoring is required for patients with severe malaria, especially those with multi-organ dysfunction, as Artesunate may not be sufficient for complete treatment.
• Artesunate should be administered with caution in patients with severe hepatic impairment, and regular liver function tests are advised.
• This injection should be used with caution in pregnant women only if the potential benefits outweigh the risks, and it is recommended for severe cases of malaria.
• Artesunate can cause hypoglycemia, so blood glucose levels should be monitored, especially in pediatric patients, malnourished individuals, and those with severe malaria.
• Patients should be observed for at least 30 minutes after the injection to monitor for any immediate adverse reactions.
• Not recommended for long-term use; complete the full course as prescribed by the healthcare provider.
• Artesunate may cause allergic reactions; seek immediate medical attention if you experience symptoms such as rash, itching, swelling, or difficulty breathing.

Following are the drug interactions for Artesunate 120mg injection:

• Artesunate may decrease the effectiveness of hormonal contraceptives, so additional non-hormonal birth control methods are recommended.
• Artesunate can reduce the efficacy of artemether, another antimalarial drug, when used concurrently.
• Concomitant use with mefloquine can increase the risk of neurotoxicity, thus close monitoring is essential.
• The injection may increase the levels of saquinavir, an antiretroviral medication, requiring dosage adjustments.
• Artesunate can interact with certain antibiotics like doxycycline, increasing the risk of side effects and altered therapeutic effects.
• When combined with chloroquine, it may lead to prolonged QT intervals, warranting cardiac monitoring.
• Caution is advised when using Artesunate with other medications metabolized by the liver, as it may impact drug metabolism.

Following are the food interactions to be aware of when taking Artesunate 120mg injection:

• Artesunate may interact with grapefruit and grapefruit juice, as these can inhibit the enzyme CYP3A4, potentially increasing drug levels in the blood and the risk of side effects.
• Alcohol consumption should be avoided as it can reduce the effectiveness of Artesunate and may cause liver-related complications.
• Fatty meals might impact the absorption of Artesunate, so it's best to take it on an empty stomach.
• Dairy products, especially milk, may interfere with the absorption of Artesunate, so avoid taking it with milk.
• Garlic supplements may increase the anti-platelet activity of Artesunate, so consult your doctor before taking them together.
• Vitamin C supplements might decrease the effectiveness of Artesunate, consult your healthcare provider for advice.
• Limit caffeine intake as it can affect the metabolism of Artesunate, potentially increasing its side effects.
• Always inform your healthcare provider about your diet and any herbal supplements you're taking to ensure safe medication use.

Artesunate 120mg injection should be stored in a controlled environment, specifically at room temperature between 20-25°C (68-77°F). Protect the injection from light and moisture by keeping it in its original packaging, ensuring the container is tightly sealed. It is crucial not to freeze the medication as it may affect its potency. Always check the expiration date, and dispose of any expired or unused injection responsibly, following local guidelines for pharmaceutical waste disposal. Do not throw it away in regular trash or pour it down the drain; consult healthcare professionals or pharmacists for appropriate disposal methods. Keep the injection out of children's reach to prevent accidental exposure.

Following are the quick tips for Artesunate 120mg injection:

• Administer the injection under medical supervision; do not self-inject.
• Ensure the injection is given at the correct site and with proper technique.
• Do not reuse needles or syringes; dispose of them safely.
• Complete the full course of treatment as prescribed by your doctor.
• Store the injection as directed on the packaging, usually at room temperature and away from direct sunlight.
• Inform your doctor if you have any allergies or medical conditions before receiving the injection.
• If you experience any severe side effects or unusual symptoms, seek immediate medical attention.
• Keep a record of your treatment progress and inform your doctor of any changes in your condition.