GEN-M Oral susp 60ml

Artemether and Lumefantrine work synergistically to combat malaria. Artemether, a derivative of artemisinin, rapidly reduces the number of malaria parasites in the blood by disrupting their digestive process and inhibiting parasite maturation. It primarily targets the parasite's food vacuole, interfering with the breakdown of hemoglobin. Lumefantrine, a long-acting partner drug, reinforces this effect by inhibiting the parasite's energy production and metabolism. It acts on the parasite's mitochondria, disrupting the synthesis of essential proteins and nucleic acids, thereby preventing the parasite's growth and replication. Together, this combination therapy effectively clears the malaria infection by attacking different stages of the parasite's life cycle.

Artemether 20mg, Lumefantrine 120mg

Antimalarial medication

Suspension

The following are the uses of Artemether 20mg, Lumefantrine 120mg Syrup/Suspension:

• Used for treating uncomplicated malaria caused by Plasmodium falciparum in adults and children.
• Used to target and eliminate the parasites responsible for malaria.
• Used to reduce symptoms such as fever, chills, and headaches associated with malaria.
• Used for preventing the progression of malaria and its complications.
• Used in combination to improve treatment effectiveness and prevent resistance.
• Used for completing the full course of treatment to ensure parasite clearance.
• Used for both the treatment and prevention of malaria in high-risk areas.

To be taken as per doctor's prescription

In the case of an overdose of Artemether 20mg and Lumefantrine 120mg Syrup/Suspension, the patient may experience an increase in the severity of common side effects such as nausea, vomiting, and dizziness. Additionally, an overdose could lead to more serious complications, including cardiac issues, severe allergic reactions, and potential liver damage. Prompt medical intervention is necessary to manage these symptoms and prevent further health risks.

In the case of a missed dose of Artemether 20mg and Lumefantrine 120mg Syrup/Suspension, it is recommended to take the missed dose as soon as possible on the same day. If it's already close to the time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. It is important to complete the full course of medication as prescribed to ensure effective treatment. Consult your healthcare provider if you have any concerns or if you miss multiple doses.

To administer Artemether 20mg and Lumefantrine 120mg syrup/suspension, shake the bottle well, and using the provided measuring device, draw out the prescribed dose, which should be taken orally as directed by your healthcare provider, typically once or twice daily with food, following the dosage instructions for your age and condition.

Following are the conditions/situations when Artemether 20mg and Lumefantrine 120mg Syrup/Suspension should not be used:

• Do not use if the patient is known to be allergic to artemether, lumefantrine, or any other ingredients in the medication.
• Avoid using this medication in patients with a history of severe liver or kidney disease.
• Not suitable for individuals with a history of prolonged QT interval or other heart rhythm disorders.
• Contraindicated in patients with a known blood disorder, such as severe anemia.
• Should not be used in children under 3 months of age or those weighing less than 5 kg.
• Do not administer if the patient is currently taking certain medications, such as rifampicin, phenytoin, or medications that prolong the QT interval.
• Not recommended for individuals with a history of seizures or epilepsy.
• Avoid using this medication if the patient has a known glucose-6-phosphate dehydrogenase (G6PD) deficiency.

The side effects of Artemether 20mg, Lumefantrine 120mg Syrup/Suspension may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain or discomfort
• Dizziness
• Headache
• Loss of appetite
• Itching or rash
• Muscle or joint pain

Following are the precautions and warnings for Artemether 20mg, Lumefantrine 120mg Syrup/Suspension:

• This medication should not be used in patients with known allergies to artemether, lumefantrine, or related compounds.
• Patients with a history of liver or kidney disease should use this medication with caution and under medical supervision, as it may require dosage adjustments.
• It is essential to complete the full course of treatment to ensure effective clearance of the parasite.
• Patients should be monitored for any signs of neurological side effects, such as dizziness, headache, or ringing in the ears, especially during the initial stages of treatment.
• Avoid driving or operating heavy machinery if you experience dizziness or other neurological symptoms.
• Artemether-lumefantrine should be used with caution in elderly patients, as they may be more susceptible to side effects.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as its safety during pregnancy and breastfeeding is not fully established.
• Store the medication at room temperature, away from moisture and light, and keep out of reach of children.

Following are the drug interactions for Artemether 20mg, Lumefantrine 120mg Syrup/Suspension:

• Concomitant use with efavirenz, nevirapine, or other antiretroviral drugs may reduce the effectiveness of artemether-lumefantrine in treating malaria, and close monitoring is required.
• Inducers of CYP3A4, such as rifampicin, may reduce the plasma concentration of artemether and lumefantrine, potentially decreasing their efficacy.
• Antacids containing aluminum or magnesium may reduce the absorption of artemether and lumefantrine, and should be administered at least 2 hours apart.
• Co-administration with halofantrine may increase the risk of cardiac adverse effects and is not recommended.
• Artemether-lumefantrine may increase the concentration of quinine, potentially leading to QT prolongation and other cardiac side effects.
• The syrup/suspension may decrease the efficacy of oral contraceptives, so alternative or additional contraceptive methods should be considered.
• Drug interactions with antimalarial agents like mefloquine or chloroquine are possible, and concurrent use should be carefully monitored.

Following are the food interactions for Artemether 20mg, Lumefantrine 120mg Syrup/Suspension:

• Grapefruit and grapefruit juice should be avoided as they may interfere with the metabolism of the medication, potentially leading to increased drug levels in the blood and an elevated risk of side effects.
• Consuming a high-fat meal before taking this medication may slightly delay the absorption of Artemether and Lumefantrine, but it is generally well-tolerated.
• Alcohol intake should be minimized or avoided as it may increase the risk of side effects, particularly gastrointestinal discomfort and dizziness.
• Spicy foods are not recommended immediately after taking the medication to reduce the likelihood of stomach irritation.
• Avoid excessive caffeine consumption as it can exacerbate side effects like nervousness and sleep disturbances.
• Maintain a balanced diet to support overall health and recovery during the treatment period.
• Always follow the dosing instructions provided by your healthcare professional, and ensure you complete the full course of medication as prescribed.
• If you have specific dietary concerns or restrictions, consult your healthcare provider for personalized advice.

Artemether 20mg, Lumefantrine 120mg Syrup/Suspension should be stored in a controlled environment, preferably in a cool and dry place away from direct sunlight. The medication should be kept at room temperature, typically between 68°F and 77°F (20°C and 25°C), and protected from moisture. It is crucial to keep the syrup in its original container, tightly sealed, to maintain its integrity and prevent contamination. Do not store it in the bathroom or kitchen, as these areas can have temperature fluctuations. Always check the expiration date, and dispose of any unused or expired medication responsibly; do not flush or pour it down the drain. Consult a pharmacist or healthcare professional for guidance on proper disposal methods, and keep the medication away from children to prevent accidental consumption.

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Following are the quick tips for Artemether 20mg, Lumefantrine 120mg Syrup/Suspension:

• Always follow the dosage instructions provided by your doctor or pharmacist.
• Administer the syrup using the provided measuring device for accurate dosing.
• Ensure the syrup is well-mixed by shaking the bottle gently before each use.
• Take the medication at evenly spaced intervals to maintain consistent drug levels.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Avoid missing doses; if you miss a dose, take it as soon as you remember, unless it's close to the next dose.
• Do not double the dose to make up for a missed one; resume your regular schedule.
• Keep a record of your dosing times to ensure you're taking it as prescribed.