Gentalek (80mg) 2ml, 50 Ampoule Injections

Gatifloxacin, a potent broad-spectrum antibiotic, exhibits its bactericidal effect by selectively inhibiting DNA gyrase and topoisomerase IV, crucial enzymes responsible for bacterial DNA replication and cell division. This inhibition leads to the introduction of double-strand breaks in bacterial DNA, ultimately resulting in cell death. The unique structure of gatifloxacin allows it to bind tightly to these enzymes, disrupting their function and effectively halting bacterial growth. By targeting these essential bacterial processes, gatifloxacin demonstrates its powerful antimicrobial activity against a wide range of pathogens.

Gatifloxacin 80mg

Quinolone antibiotic.

Injection

The following are the uses of Gatifloxacin 80mg injection:

• Used for treating community-acquired pneumonia
• Used for controlling infections in patients with weakened immune systems or those undergoing certain medical procedures.
• Used for treating bone and joint infections, ensuring effective delivery of the antibiotic to the site of infection.
• Used for managing intra-abdominal infections, providing rapid and potent antibacterial action.
• Used for treating respiratory tract infections caused by susceptible bacteria, aiding in quick recovery.
• Used for preventing and controlling infections in patients with severe burns or open wounds, reducing the risk of complications.

In the case of an overdose of Gatifloxacin 80mg injection, it is crucial to seek medical assistance promptly. Symptoms of an overdose may include dizziness, headache, and gastrointestinal distress. The severity of the reaction depends on the amount ingested and individual sensitivity. Quick action and medical intervention are vital to mitigate potential health risks associated with an overdose of this medication. Timely medical care can effectively manage and treat any adverse effects.

In the case of a missed dose of Gatifloxacin 80mg injection, it is important to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for the missed one. However, if you realize the missed dose within a few hours of the scheduled time, administer the injection right away. It is crucial to maintain a consistent medication routine, but if you frequently miss doses, inform your healthcare provider for further guidance.

To administer the Gatifloxacin 80mg injection, prepare the medication by drawing the prescribed dose into a syringe, then locate a suitable injection site, clean the area with an alcohol swab, and carefully inject the medication into the muscle, ensuring the entire dose is delivered as directed by your healthcare provider.

Following are the conditions or circumstances when Gatifloxacin 80mg injection should not be administered:

• Allergic reaction Should not be used if the patient has a known allergy to Gatifloxacin or other quinolone antibiotics.
• Pregnancy and breastfeeding Contraindicated in pregnant and breastfeeding women due to potential risks to the fetus and infant.
• Central Nervous System (CNS) disorders Not recommended for individuals with a history of seizures or other CNS disorders, as it may lower the seizure threshold.
• Heart conditions Should be avoided in patients with a known history of prolonged QT interval or other heart-related issues.
• Kidney impairment Gatifloxacin injection should be used with caution in patients with kidney problems, and dosage adjustments may be required.
• Children and adolescents Not recommended for use in pediatric patients under 18 years of age due to potential risks to bone and joint development.
• Myasthenia gravis Contraindicated in patients with myasthenia gravis as it may worsen muscle weakness.
• Tendinitis and Tendon Rupture Gatifloxacin should be discontinued if the patient experiences tendinitis or tendon rupture during treatment.
• Diabetes Caution should be exercised in diabetic patients as Gatifloxacin may affect blood glucose levels.

The side effects of Gatifloxacin 80mg injection may include:

• Diarrhea
• Nausea and vomiting
• Headache
• Dizziness
• Skin rash or itching
• Increased sensitivity to sunlight
• Confusion, disorientation, or hallucinations (especially in elderly patients)
• Tendinitis or tendon rupture

Following are the precautions and warnings for Gatifloxacin 80mg Injection:

• Avoid use in patients with known hypersensitivity to gatifloxacin, any other quinolone antibiotics, or any of the components of the injection.
• Gatifloxacin should be used with caution in patients with a history of tendon disorders, as it may increase the risk of tendonitis or tendon rupture, particularly in older adults and those on corticosteroid therapy.
• It should not be used in patients with a history of seizures or conditions that predispose to seizures, as it may lower the seizure threshold.
• Use with caution in patients with renal impairment, as the dosage may need to be adjusted in cases of renal dysfunction.
• Gatifloxacin may cause QT interval prolongation, so it should be used with caution in patients with a history of arrhythmias or those receiving other drugs that prolong the QT interval.
• Patients with a history of liver disease should be monitored closely, as hepatic reactions, including liver failure, may occur.
• Not recommended for use in pregnant or breastfeeding women unless clearly necessary; consult a healthcare provider before use.
• It may cause dizziness, drowsiness, or visual disturbances, so patients should be cautious when operating machinery or driving.
• Overuse of antibiotics like gatifloxacin can lead to the development of drug-resistant bacteria; it should only be used for the prescribed infection.
• If signs of a severe allergic reaction (rash, itching, swelling, difficulty breathing) occur, discontinue use immediately and seek medical attention.
• Prolonged or repeated use may lead to superinfection, including fungal or resistant bacterial infections.
• Always follow the prescribed dosage and consult a healthcare provider if any unusual symptoms or side effects occur.

Following are the drug interactions for Gatifloxacin 80mg injection:

• Gatifloxacin may enhance the effects of anticoagulants like warfarin, requiring close monitoring of prothrombin time.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) might increase the risk of seizures when used with Gatifloxacin.
• Concomitant use with other medications that prolong QT interval, such as antiarrhythmics or certain antipsychotics, can lead to cardiac arrhythmias.
• The effectiveness of live attenuated vaccines, such as the measles vaccine, may be reduced during Gatifloxacin therapy.
• Gatifloxacin can increase the risk of hypoglycemia when used with sulfonylureas or insulin in diabetic patients.
• Theophylline levels may be elevated when co-administered with Gatifloxacin, potentially increasing the risk of theophylline toxicity.
• It may decrease the efficacy of BCG vaccine, oral typhoid vaccine, and live oral polio vaccine.

Following are the food interactions for Gatifloxacin 80mg injection:

• Avoid consuming dairy products like milk, cheese, and yogurt, as they can decrease the absorption of Gatifloxacin, reducing its effectiveness.
• Grapefruit and grapefruit juice are to be avoided as they may interfere with the metabolism of Gatifloxacin, potentially leading to increased drug levels in the body.
• Limit caffeine intake from coffee, tea, or energy drinks as it can enhance the side effects of Gatifloxacin, causing increased nervousness, restlessness, and insomnia.
• Alcohol consumption should be minimized as it can increase the risk of liver-related side effects and may also intensify the dizziness and lightheadedness associated with Gatifloxacin.
• Avoid high-sugar foods and beverages as they can interfere with the effectiveness of Gatifloxacin, especially in diabetic patients.
• Stay hydrated by drinking plenty of water, as Gatifloxacin may increase the risk of dehydration and electrolyte imbalances.
• Consume a balanced diet rich in lean proteins, whole grains, and fresh fruits and vegetables to support overall health and recovery during the course of treatment.
• Follow any specific dietary instructions provided by your healthcare professional, especially if you have any underlying health conditions.

Gatifloxacin 80mg injection should be stored in a controlled environment, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Protect the injection from direct sunlight and moisture by keeping it in its original packaging, ensuring the container is tightly sealed. Avoid storing it in the bathroom or near heat-emitting appliances to prevent exposure to extreme temperatures. Always check the expiration date before use and discard any expired or unused injections according to local regulations and guidelines. Proper disposal is crucial; do not pour the medication down the drain or flush it, but consult a pharmacist or healthcare professional for appropriate disposal methods. Keep this medication safely locked away from children and pets to prevent accidental exposure or ingestion.

Following are the quick tips for Gatifloxacin 80mg injection:

• Administer the injection under medical supervision for best results.
• Ensure proper injection technique to minimize discomfort.
• Follow the prescribed dosage and duration of treatment.
• Inform your doctor about any allergies or medical conditions before use.
• Store the injection as directed on the label, away from direct sunlight and moisture.
• Dispose of used needles and syringes safely to prevent injuries and infections.
• Do not reuse or share needles to prevent the spread of infections.
• In case of any adverse reactions, seek immediate medical attention.