GESTONE 100MG INJ IMP (PROGESTERONE)

Progesterone 100mg Injection exerts its effects primarily through its interaction with progesterone receptors in various target tissues. Once administered, progesterone binds to these receptors, which are present in the uterus, breasts, and other reproductive organs. This binding activates specific gene expression pathways, leading to changes in cellular function. One of the key actions of progesterone is the regulation of the uterine lining, promoting its thickening and preparing it for potential implantation during pregnancy. It also helps maintain the pregnancy by inhibiting uterine contractions and promoting the development of blood vessels in the placenta. Additionally, progesterone plays a role in breast development and milk production. By influencing these physiological processes, progesterone contributes to maintaining pregnancy and supporting reproductive functions.

Progestin.

Injection

The following are the uses of Progesterone 100mg Injection:

• Used for treating women who have not reached menopause and have a type of advanced breast cancer that tests positive for estrogen receptors.
• Used in hormone replacement therapy to relieve symptoms of menopause such as hot flashes and vaginal changes.
• Used to treat women who have irregular or absent periods, often due to hormonal imbalances.
• Used in assisted reproductive technologies to support and prepare the uterus for embryo implantation.
• Used for endometrial protection during estrogen replacement therapy, reducing the risk of endometrial hyperplasia.
• Used to treat women with amenorrhea, helping to induce a menstrual period.
• Used in certain cases of infertility to support pregnancy and maintain a healthy pregnancy.

In the case of an overdose of Progesterone 100mg Injection, it is important to recognize the signs and symptoms, which may include severe drowsiness, dizziness, and gastrointestinal issues like nausea and vomiting. If an overdose is suspected, immediate action should be taken. Contact a healthcare professional or seek medical advice promptly to determine the best course of action. Treatment may involve supportive care and monitoring to ensure the patient's safety and well-being.

In the case of a missed dose of Progesterone 100mg Injection, it is important to administer the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Avoid doubling the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your dosing schedule. It is advisable to set reminders or alarms to help you stay on track with your medication routine.

To administer Progesterone 100mg Injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and slowly inject the prescribed dose into the muscle, ensuring the entire medication is delivered before withdrawing the needle.

Here are the conditions and situations when Progesterone 100mg Injection should not be used:

• Should not be administered to individuals with a known allergy or hypersensitivity to progesterone or any of the excipients in the injection.
• Contraindicated in patients with a history of blood clots or who are at high risk for thromboembolic disorders.
• Not recommended for use in women with a history of breast cancer or any estrogen-dependent tumors.
• Should be avoided in individuals with undiagnosed vaginal bleeding or endometrial hyperplasia.
• Contraindicated in patients with liver disease or impaired liver function as it can lead to severe adverse effects.
• Not suitable for pregnant women, especially during the first trimester, unless the potential benefits outweigh the risks.
• Should not be used in patients with a history of or active cardiovascular diseases, such as heart attack or stroke.
• Avoid use in individuals with severe kidney impairment or kidney failure.
• Contraindicated in patients with a history of or active thrombophlebitis or thromboembolic disorders.

The side effects of Progesterone 100mg Injection may include:

• Fatigue and weakness.
• Dizziness or lightheadedness.
• Breast tenderness or pain.
• Mood changes, including depression or irritability.
• Headaches or migraines.
• Nausea and vomiting.
• Skin reactions such as rashes, itching, or hives.
• Changes in menstrual bleeding patterns.

Following are the precautions and warnings for Progesterone 100mg Injection:

• Avoid use in patients with known hypersensitivity to progesterone or any of its components.
• Use with caution in patients with a history of liver disease, as it may affect liver function.
• Not recommended in patients with a history of thromboembolic disorders (e.g., deep vein thrombosis, pulmonary embolism) or stroke.
• Should be used with caution in patients with a history of breast cancer or other hormone-dependent cancers.
• Monitor patients for signs of mood changes, depression, or suicidal thoughts, as progesterone may cause mood swings.
• Progesterone should not be used during pregnancy unless clearly necessary, as it may affect fetal development.
• May cause drowsiness or dizziness; patients should avoid driving or operating heavy machinery if they experience these symptoms.
• Use with caution in patients with diabetes, as progesterone may affect blood sugar levels.
• Avoid abrupt discontinuation after prolonged use to prevent withdrawal symptoms or irregular bleeding.
• May cause fluid retention or edema, particularly in patients with kidney or heart disease.
• Not recommended during breastfeeding without medical supervision, as progesterone can pass into breast milk.

Following are the drug interactions for Progesterone 100mg Injection:

• May interact with other hormonal medications like estrogens, androgens, or corticosteroids, leading to altered effects of either drug.
• Can affect the metabolism of enzyme-inducing drugs such as rifampicin, potentially reducing progesterone levels.
• May decrease the effectiveness of hypoglycemic agents like insulin or metformin in diabetic patients.
• Progesterone can increase the sedative effects of central nervous system depressants, including benzodiazepines and opioids.
• Antifungal medications like ketoconazole can affect progesterone metabolism, potentially increasing its levels.
• Drugs that inhibit certain liver enzymes (e.g., CYP3A4 inhibitors) may lead to higher progesterone concentrations in the body.
• Caution is advised when using with herbal supplements like St. John's Wort, as it may reduce progesterone levels.

Following are the food interactions for Progesterone 100mg Injection:

• Avoid excessive caffeine intake as it may interfere with progesterone absorption and increase anxiety and restlessness.
• Limit the consumption of foods high in saturated fats, as they may negatively impact hormone balance and overall health.
• Grapefruit and grapefruit juice should be consumed in moderation as they can affect hormone metabolism.
• Alcohol intake should be minimized as it may disrupt hormone levels and potentially interact with progesterone's effects.
• Maintain a balanced diet with adequate protein, whole grains, and fresh fruits and vegetables to support overall well-being during progesterone therapy.
• Stay hydrated by drinking enough water to ensure proper circulation and distribution of progesterone in the body.
• Avoid excessive sugar consumption, as it may impact hormone regulation and overall health.

Progesterone 100mg Injection requires careful storage and disposal to maintain its integrity and ensure safety. Store the injection in a cool, dry place, preferably at room temperature, away from direct sunlight and moisture. Keep the medication in its original packaging, tightly sealed, to maintain sterility and prevent contamination. Avoid extreme temperatures by not placing it near heat sources or in the refrigerator. Regularly check the expiration date, and do not use the injection if it has expired. When disposing of unused or expired injections, do not flush or pour them down the drain; instead, follow local guidelines or consult healthcare professionals for safe disposal methods. Keep the injection out of children's reach to prevent accidental exposure.

Following are the quick tips for Progesterone 100mg Injection:

• Consult a doctor before use, especially if you have a medical history of blood clots, liver or heart disease.
• Inform your doctor about all medications you're taking to avoid potential interactions.
• Administer the injection as directed by your healthcare provider, ensuring proper dosage and technique.
• Avoid injecting into veins; intramuscular or subcutaneous administration is recommended.
• Do not reuse needles; dispose of them safely after each use.
• Store the injection at room temperature, away from direct sunlight and moisture.
• In case of any adverse reactions or persistent symptoms, seek immediate medical attention.