Glantrim (2/0.5%) 5ml Eye Drops

Dorzolamide, a carbonic anhydrase inhibitor, primarily acts by reducing the production of aqueous humor in the eye. It inhibits carbonic anhydrase, an enzyme responsible for the formation of bicarbonate ions, which are essential for aqueous humor secretion. By decreasing aqueous humor production, Dorzolamide lowers intraocular pressure. Timolol, on the other hand, is a beta-adrenergic antagonist that works by reducing the production of aqueous humor and enhancing its outflow. It blocks beta-adrenergic receptors in the ciliary body, inhibiting the action of beta-adrenergic agonists, which are involved in aqueous humor secretion. This dual mechanism of action, combined with the beta-blocking effect of Timolol, results in a more effective reduction of intraocular pressure in conditions like ocular hypertension and open-angle glaucoma.

Dorzolamide, Timolol

Beta-adrenergic blocker, Carbonic anhydrase inhibitor

Drop

The following are the uses of Dorzolamide, Timolol Drop:

• Used for reducing eye pressure in patients with glaucoma or ocular hypertension.
• Used to lower intraocular pressure, preventing optic nerve damage and vision loss.
• Used for managing fluid drainage in the eye, reducing the risk of eye strain and fatigue.
• Used to treat open-angle glaucoma, helping to maintain clear vision.
• Used for preventing further vision deterioration and managing symptoms.
• Used to slow down the progression of the disease, improving overall eye health.
• Used as a combination medication to maximize pressure reduction in the eyes.

To be used as per doctor's instructions

In the case of an overdose of Dorzolamide and Timolol eye drops, it is important to remain calm and take immediate action. Rinse your eyes thoroughly with warm water for several minutes to dilute and wash away any excess medication. Seek medical advice promptly, even if there are no immediate symptoms, as eye drops can cause systemic effects if absorbed into the bloodstream. A healthcare professional will provide guidance and may recommend monitoring for potential side effects related to the overdose.

In the case of a missed dose of Dorzolamide and Timolol eye drops, it is recommended to administer the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not use extra drops to make up for the missed dose, as this may increase the risk of side effects. If you frequently miss doses, consider setting an alarm or using a medication reminder app to help you stay on track. Consult your healthcare provider if you have any concerns or questions about managing missed doses.

To administer Dorzolamide, Timolol eye drops, gently tilt your head back, pull down the lower eyelid to create a pocket, and hold the dropper tip close to the eye without touching it, then squeeze out a single drop into the pocket, blinking gently to ensure the medication is absorbed.

Following are the conditions/situations when Dorzolamide, Timolol Eye Drops should not be used:

• Should not be used in individuals with a known allergy to Dorzolamide, Timolol or any of its components.
• Contraindicated in patients with severe respiratory diseases such as asthma or chronic obstructive pulmonary disease (COPD).
• Not recommended for individuals with a slow heart rate (bradycardia) or heart block.
• Should not be used in patients with severe kidney disease or those on dialysis.
• Contraindicated during an episode of closed-angle glaucoma.
• Not suitable for individuals with a history of heart failure or severe heart conditions.
• Should be avoided in patients with a history of severe allergic reactions or bronchial asthma.
• Not recommended for use in children or adolescents.
• Should not be used if you have a condition that affects the blood vessels in your eyes (ocular vascular disease).

The side effects of Dorzolamide, Timolol Drop may include:

• Stinging or burning sensation in the eyes
• Blurred vision
• Eye fatigue or discomfort
• Headache
• Bitter or unusual taste in the mouth
• Itchy or watery eyes
• Dry eyes
• Dizziness

Following are the precautions and warnings for Dorzolamide, Timolol Eye Drops:

• Do not use these eye drops if you are allergic to any of their ingredients, including Dorzolamide and Timolol.
• If you have a history of respiratory diseases like asthma or chronic obstructive pulmonary disease (COPD), use with caution as Timolol may exacerbate these conditions.
• Patients with heart problems, low blood pressure, or a history of heart disease should exercise caution as Timolol can affect heart rate and blood pressure.
• Dorzolamide may cause systemic side effects if absorbed into the bloodstream, especially in patients with kidney or liver problems.
• These eye drops may cause temporary blurred vision or other visual disturbances. Avoid driving or operating machinery until you know how the medication affects you.
• Contact lenses should be removed before applying the drops and can be reinserted after 15 minutes.
• Children and pregnant or breastfeeding women should use these eye drops only if clearly needed and under medical supervision.
• Store the eye drops properly and keep out of reach of children and pets.

Following are the drug interactions for Dorzolamide, Timolol Eye Drops:

• Concomitant use with other beta-blockers or oral carbonic anhydrase inhibitors may lead to additive effects and increased risk of adverse reactions.
• Drugs affecting cardiac conduction, such as calcium channel blockers or Class I antiarrhythmic agents, can have a negative impact on heart rate and rhythm when used with Timolol.
• Using Dorzolamide with other carbonic anhydrase inhibitors (e.g., acetazolamide) may increase the risk of metabolic acidosis and renal stones.
• The effectiveness of Timolol may be reduced when used with adrenergic receptor agonists, including epinephrine or clonidine.
• Insulin or oral hypoglycemic agents' blood sugar-lowering effects may be hindered by Timolol.
• Digitalis glycosides' effect on heart function may be enhanced, increasing the risk of arrhythmias.
• The use of Dorzolamide with brimonidine eye drops may increase the risk of ocular side effects, including corneal erosion.

Following are the food interactions for Dorzolamide, Timolol Drop:

• Avoid consuming alcohol while using this medication, as it can increase the risk of systemic absorption and may lead to increased side effects, especially drowsiness and dizziness.
• Grapefruit and grapefruit juice should be consumed with caution as they can potentially interfere with the metabolism of Timolol, leading to increased drug levels in the body and a higher risk of side effects.
• Avoid high-sodium foods and processed foods as Timolol may be less effective in lowering blood pressure when consumed with a high-sodium diet.
• Caffeine intake should be monitored as it can increase eye pressure temporarily, working against the pressure-lowering effect of Dorzolamide.
• Avoid or limit the consumption of foods rich in potassium, such as bananas, oranges, and spinach, as Dorzolamide can cause systemic effects that may lead to elevated potassium levels.
• Avoid or limit the use of chocolate, as it contains compounds that can potentially increase eye pressure, counteracting the effects of the medication.
• No significant food interactions are known for Dorzolamide, but it's best to consult your doctor or pharmacist for personalized advice.
• Always follow the instructions provided by your healthcare professional regarding dietary restrictions and medication use.

Dorzolamide, Timolol Eye Drops should be stored with utmost care, ensuring a cool and dry environment, preferably at room temperature, shielded from direct sunlight and moisture. The original container must be tightly sealed to maintain its integrity and prevent contamination. Avoid exposing the drops to extreme temperatures, steering clear of storage in bathrooms or near heat sources like stoves or radiators. Prior to each use, inspect the expiration date, and for any signs of deterioration. Disposal of unused or expired drops should be done responsibly; refrain from flushing or pouring them down the drain. Consult your pharmacist or healthcare provider for specific instructions on proper disposal methods, and always keep medications out of children's reach to prevent accidental exposure.

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Following are the quick tips for Dorzolamide, Timolol Drop:

• Wash your hands before administering the eye drops to maintain hygiene.
• Tilt your head back, look upward, and gently pull down your lower eyelid to create a pocket.
• Hold the dropper close to your eye and squeeze out the prescribed number of drops into the pocket.
• Close your eyes gently and apply light pressure to the inner corner of your eye for 1-2 minutes to prevent drainage.
• Avoid touching the dropper tip to your eye or any surface to prevent contamination.
• If you wear contact lenses, remove them before using the drops and wait at least 15 minutes before reinserting them.
• Do not skip doses as it may reduce the effectiveness of the medication.
• Store the eye drops at room temperature, away from direct sunlight and moisture.