Glukil (5mg) 60 Tablets

Glibenclamide performs its effect by stimulating insulin release from the pancreatic beta cells; reducing glucose output from the liver; increasing insulin sensitivity at peripheral target sites. Glibenclamide is a sulfonylurea oral hypoglycemic drug. This medicine works by increasing secretion of insulin from the pancreas, it interacts with sulfonylurea receptors on beta cells or interferes with ATP-sensitive potassium channels on pancreatic beta cells, which increases secretion of insulin. This medicine also increases sensitivity of existing insulin receptors.

Glibenclamide

Tablet

Diabetes Type 2

Dose must be taken according to the doctor’s advice only; doses given below are suggested as supportive literature for better understanding in some areas of requirements. Adult dose: Initial dose is; 2.5-5mg orally a day. Maintenance dose is; 1.25-20mg orally a day or every 12 hours. Do not exceed 20mg per day. Administer with interval of 12 hours for doses >10mg per day. Elderly (>65 years) dose: Initial dose is 1.25mg per day. Dose may be increased according to patient’s condition but not more than 1.25-2.5mg every week. Administer with interval of 12 hours for doses >10mg per day.

Overdose of glibenclamide can cause prolong hypoglycemia. Consult your doctor for management of overdose.

In case you missed any dose, take the next dose as soon as you remember, but don't double your next dose to compensate for the missed one.

Take it orally with water after breakfast or main meal.

Cannot be used in case of hypersensitivity to glibenclamide or any component of the formulation, do not use in type 1 diabetes mellitus or diabetic ketoacidosis, with or without coma, liver disease or frank jaundice, kidney impairment, pregnancy and breastfeeding.

glibenclamide at the time of delivery.

Glibenclamide presence in breast milk may cause hypoglycemia in infants. Severe hypoglycemia lasting 4 to 10 days may occur in infants born to mothers taking a sulfonylurea like

Beta-Blockers, Ranitidine, Clarithromycin, Alpha-Glucosidase Inhibitors drugs and Amiodarone may enhance the hypoglycemic effect of Sulfonylureas like; glibenclamide. Alpha-Lipoic Acid may enhance the hypoglycemic effect of antidiabetic agents like; glibenclamide. Glibenclamide may enhance the adverse/toxic effect of Carbocisteine. Chloramphenicol (Systemic) and Letermovir may increase the serum concentration of glibenclamide. Colesevelam may decrease the serum concentration of glibenclamide. Thiazide and Thiazide-Like Diuretics and Cyclosporine (Systemic) may diminish the therapeutic effect of glibenclamide. Bosentan cannot be used along with glibenclamide

If you are diabetic, go for the following tests: Glucose Tolerance Test, Blood sugar test, Blood Glucose Fasting Test