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Glukil (5mg) 60 Tablets
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- Manufacturer Swiss Pharmaceuticals (Pvt.) Ltd.
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Generic Name
Glibenclamide 5mg
Healthwire Pharmacy Ratings & Reviews (1500+)
4.9/
5
Delivery by Today, 9:00 am - 12:00 pm
Product Information
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Description
Glibenclamide performs its effect by stimulating insulin release from the pancreatic beta cells; reducing glucose output from the liver; increasing insulin sensitivity at peripheral target sites. Glibenclamide is a sulfonylurea oral hypoglycemic drug. This medicine works by increasing secretion of insulin from the pancreas, it interacts with sulfonylurea receptors on beta cells or interferes with ATP-sensitive potassium channels on pancreatic beta cells, which increases secretion of insulin. This medicine also increases sensitivity of existing insulin receptors. -
Ingredients
Glibenclamide 5mg
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Dosage Form
Tablet
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Uses
Glibenclamide is utilized for the following therapeutic indications:
- Managing type 2 diabetes
- Stimulating insulin secretion
- Reducing blood glucose levels
- Improving glycemic control
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Dosage
Dose must be taken according to the doctor’s advice only; doses given below are suggested as supportive literature for better understanding in some areas of requirements. Adult dose: Initial dose is; 2.5-5mg orally a day. Maintenance dose is; 1.25-20mg orally a day or every 12 hours. Do not exceed 20mg per day. Administer with interval of 12 hours for doses >10mg per day. Elderly (>65 years) dose: Initial dose is 1.25mg per day. Dose may be increased according to patient’s condition but not more than 1.25-2.5mg every week. Administer with interval of 12 hours for doses >10mg per day. -
In case of Overdose
Overdose of glibenclamide can cause prolong hypoglycemia. Consult your doctor for management of overdose. -
Missed Dose
In case you missed any dose, take the next dose as soon as you remember, but don't double your next dose to compensate for the missed one. -
How To Use
Take it orally with water after breakfast or main meal. -
When Not to Use
Cannot be used in case of hypersensitivity to glibenclamide or any component of the formulation, do not use in type 1 diabetes mellitus or diabetic ketoacidosis, with or without coma, liver disease or frank jaundice, kidney impairment, pregnancy and breastfeeding. -
Side Effects
glibenclamide at the time of delivery. -
Precautions & Warnings
Glibenclamide presence in breast milk may cause hypoglycemia in infants. Severe hypoglycemia lasting 4 to 10 days may occur in infants born to mothers taking a sulfonylurea like -
Food Interactions
Beta-Blockers, Ranitidine, Clarithromycin, Alpha-Glucosidase Inhibitors drugs and Amiodarone may enhance the hypoglycemic effect of Sulfonylureas like; glibenclamide. Alpha-Lipoic Acid may enhance the hypoglycemic effect of antidiabetic agents like; glibenclamide. Glibenclamide may enhance the adverse/toxic effect of Carbocisteine. Chloramphenicol (Systemic) and Letermovir may increase the serum concentration of glibenclamide. Colesevelam may decrease the serum concentration of glibenclamide. Thiazide and Thiazide-Like Diuretics and Cyclosporine (Systemic) may diminish the therapeutic effect of glibenclamide. Bosentan cannot be used along with glibenclamide -
Storage/Disposal
If you are diabetic, go for the following tests: Glucose Tolerance Test, Blood sugar test, Blood Glucose Fasting Test
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