GLURENOR 30MG TAB

Gliquidone 30MG Tablet, a second-generation sulfonylurea, primarily exerts its hypoglycemic effects by stimulating insulin release from pancreatic beta cells. It selectively binds to sulfonylurea receptors on the beta-cell membrane, leading to the inhibition of ATP-sensitive potassium channels. This inhibition results in membrane depolarization, opening of voltage-gated calcium channels, and subsequent calcium influx into the beta cells. The increased intracellular calcium triggers insulin secretion, which plays a crucial role in lowering blood glucose levels by promoting glucose uptake and utilization in peripheral tissues. This mechanism of action makes Gliquidone effective in managing type 2 diabetes mellitus, particularly in individuals with residual pancreatic function.

Gliquidone 30MG

Sulfonylurea derivative

Tablet

The following are the uses of Gliquidone 30MG Tablet:

• Used for controlling high blood sugar levels in type 2 diabetes mellitus
• Used to improve insulin sensitivity and reduce insulin resistance
• Used to help lower blood glucose levels after meals
• Used to manage diabetes when diet and exercise alone are not sufficient
• Used to prevent long-term complications of diabetes
• Used to stabilize blood sugar fluctuations
• Used to enhance insulin production in the pancreas
• Used for overall glycemic control

In the case of an overdose of Gliquidone 30MG Tablets, immediate symptoms may include severe hypoglycemia, leading to confusion, rapid heartbeat, and seizures. If a large amount is ingested, it can result in prolonged hypoglycemia, requiring prompt medical intervention. Timely recognition and treatment are essential, as severe cases may lead to loss of consciousness, coma, or even death. Quick action is vital to prevent potential long-term complications.

In the case of a missed dose of Gliquidone 30MG Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication and adjust your dosing schedule.

To take Gliquidone 30MG Tablet, swallow the tablet whole with a glass of water, preferably with your breakfast or the first main meal of the day, following the dosage instructions provided by your healthcare professional.

Gliquidone 30MG Tablet should not be used in the following conditions:

• Not recommended for individuals with a known allergy to Gliquidone or sulfonylurea medications.
• Contraindicated in patients with type 1 diabetes mellitus.
• Should not be used to treat diabetic ketoacidosis.
• Not suitable for individuals with severe kidney or liver impairment.
• Avoid using if you have a severe infection, severe injury, or are undergoing surgery.
• Do not use if you have a history of a serious condition called hemolytic anemia.
• Contraindicated in patients with a rare metabolic disorder called glucose-6-phosphate dehydrogenase (G6PD) deficiency.

The side effects of Gliquidone 30MG Tablet may include:

• Hypoglycemia (low blood sugar)
• Nausea and vomiting
• Stomach pain or discomfort
• Diarrhea
• Skin rash or itching
• Weight gain
• Dizziness or lightheadedness
• Blurred vision

Following are the precautions and warnings for Gliquidone 30MG Tablet:

• Patients with a known allergy to Gliquidone or other sulfonylurea drugs should not take this medication.
• Regular monitoring of blood glucose levels is necessary, and adjustments may be required during periods of illness, stress, or changes in diet and exercise.
• Caution is advised in patients with kidney or liver disease, as the dosage may need to be adjusted.
• Alcohol consumption should be avoided or limited as it can affect blood sugar control.
• Gliquidone may cause hypoglycemia, so patients should be aware of the symptoms and carry a source of glucose (e.g., glucose tablets) to treat low blood sugar.
• Elderly patients may be more susceptible to the hypoglycemic effects of Gliquidone, and dosage adjustments might be necessary.
• This medication should be used with caution in individuals with thyroid, adrenal, or pituitary disorders, as these conditions can affect blood sugar levels.
• Patients should be educated about the importance of adhering to the prescribed diet and exercise plan while taking Gliquidone.

Following are the drug interactions for Gliquidone 30MG Tablet:

• Alcohol consumption may cause excessive blood sugar lowering and lead to hypoglycemia.
• Beta-blockers, like metoprolol, can mask the symptoms of hypoglycemia, making it harder to detect.
• Gliquidone may increase the blood-thinning effects of anticoagulants such as warfarin, requiring close monitoring.
• Diuretics, especially thiazide diuretics, can increase blood sugar levels, which may require adjustment of gliquidone dosage.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) can elevate blood sugar and reduce the effectiveness of gliquidone.
• Corticosteroids may raise blood glucose, necessitating adjustments in gliquidone dosage.
• Certain medications, like rifampicin, can reduce the effectiveness of gliquidone by increasing its metabolism.
• Drugs affecting liver enzymes, such as enzyme inducers or inhibitors, may alter gliquidone's metabolism and require dosage adjustments.

Following are the food interactions for Gliquidone 30MG Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can increase the drug's availability in the body, leading to potential hypoglycemic episodes.
• Alcohol intake should be cautious as it can affect blood sugar levels and interact with the medication, increasing the risk of side effects and altering the drug's effectiveness.
• Avoid high-fat meals as they can delay the absorption of Gliquidone, potentially affecting blood glucose control.
• Consuming garlic may increase the risk of hypoglycemia, so monitor blood sugar levels closely.
• Licorice should be used cautiously as it can decrease the effectiveness of Gliquidone and affect blood sugar control.
• Green tea may enhance the blood-sugar-lowering effect, so monitor glucose levels and adjust the dosage if necessary.
• Ginger, when taken in large amounts, might lower blood sugar, requiring careful monitoring.
• No significant interactions with dairy products have been reported, but always follow healthcare provider's advice on dietary considerations.

Gliquidone 30MG Tablets should be stored in a secure and dry location, preferably in a medicine cabinet, at room temperature (68°F to 77°F or 20°C to 25°C). Keep the tablets in their original container, tightly sealed, to protect them from moisture and light. It is crucial not to store them in the bathroom or kitchen, as these areas can expose the medication to heat and humidity. Always check the expiration date, and if the tablets are past their expiry, do not use them and dispose of them properly. Dispose of unused or expired medication responsibly; do not throw it into the trash or flush it down the toilet. Contact your pharmacist or local waste management authority for guidance on safe disposal methods. Keep the medication away from children and pets to prevent accidental consumption.

Following are the quick tips for Gliquidone 30MG Tablet:

• Consult your doctor for the right dosage based on your medical condition and response to treatment.
• Take the tablet by mouth as directed, usually once or twice daily with or without food.
• Swallow the tablet whole without crushing or chewing for optimal effects.
• Maintain a consistent medication schedule and take it at the same time(s) each day.
• Do not double the dose to catch up if you miss a dose; take it as soon as you remember.
• Inform your doctor about all medications you are taking to avoid potential interactions.
• Regularly monitor your blood sugar levels as directed by your healthcare provider.
• Store the medication at room temperature, away from moisture and light.