GLUSIMET XR TAB 50/1000

Sitagliptin works by inhibiting the breakdown of incretins, hormones that regulate blood sugar levels. By keeping these hormones in the bloodstream longer, insulin production is stimulated only when blood sugar levels are elevated, effectively reducing blood sugar levels in patients with type 2 diabetes mellitus. Metformin is a drug that belongs to the biguanide class, and it works by reducing glucose production in the liver and increasing glucose absorption by skeletal muscles. Unlike other drugs for managing type 2 diabetes, Metformin does not increase insulin secretion from the pancreas. This feature helps reduce the excessive workload on the pancreas, which is particularly beneficial for those whose pancreas is producing less insulin or whose bodies are resistant to insulin effects.

Metformin:

Unveiling its multifaceted uses and transformative applications as follows:

• Treatment of type 2 diabetes mellitus with sitagliptin (a DPP-4 inhibitor) has shown to slow the digestion of insulin, allowing medications like metformin to be more effective and aiding in boosting your own insulin production.
• This medication aids in lowering your HbA1c blood test results, quickly seeing lower blood glucose levels, and assisting in maintaining your blood sugar levels.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For treating type 2 diabetes, the recommended dose of Sitagliptin is 100mg to be taken once a day.
• The recommended dose of Metformin is 2000mg to be taken twice a day.

An overdose of sitagliptin and metformin can profoundly affect your health. Symptoms may range from hypoglycemia or gastrointestinal problems. It is vital to seek medical attention if you or someone you know experiences an overdose of these drugs. The medical team will provide supportive care, which includes the monitoring of vital signs, oxygen supplementation, and intravenous glucose to combat low blood sugar. In more severe cases, treatments such as dialysis or liver dialysis may be employed to remove the medications from the body. Should the overdose occur recently, the healthcare team may induce vomiting to minimize the absorption of the drugs.It is imperative to seek immediate medical attention due to the potential for severe complications arising from metformin overdose, which may include hypokalemia, kidney failure, or lactic acidosis. An overdose of sitagliptin, on the other hand, may lead to severe pancreatitis. Remember,

It is important to contact your doctor or healthcare provider for guidance if you have missed a dose of medication. They may recommend taking the missed dose as soon as possible unless it is close to your next scheduled dose. In this case, it is best to skip the missed dose and continue with your regular schedule to avoid overlapping doses. Be aware of any health changes and monitor your symptoms closely. Should you experience any adverse effects, contact your doctor right away for guidance on adjusting your dosage or scheduling. Make note of the missed dose and discuss it with your doctor or pharmacist at your next appointment for more advice on adhering to your treatment plan. Consulting with a medical professional is always recommended for the best guidance specific to your condition and medication regimen.

When taking Sitagliptin and Metformin, there are important directions and factors to keep in mind. Sitagliptin is typically taken once daily, at the same time each day, with or without food. While some may take 50 mg of Sitagliptin twice a day, taking the second dose at least 12 hours after the first. Metformin is usually taken 2-3 times a day, with meals, as the first bite of food or within 30 minutes of starting a meal. The recommended starting dose is 500 mg twice a day, with a dose range of 500 to 2000 mg divided into two or three doses per day. It's important to take these medications as directed and not to exceed the recommended dosage. If a dose is missed, it is best to take it as soon as possible unless it is closer to the next scheduled dose. During treatment, it is important to regularly monitor and maintain control of your blood glucose levels, and keep appointments with your doctor to ensure your medication plan is working properly.

Discerning instances where this medication may not be appropriate:

• Hypoglycemia (Low Blood Sugar)

• Kidney Problems

• Lactation and Pregnancy

• Gastrointestinal Disturbances

• Hypersensitivity

• Concurrent Use with Other Drugs

Unraveling the side effects lurking behind this medications are as follows:

• Upper respiratory tract infection
• Headache
• Diarrhea
• Viral infection
• Nasopharyngitis
• Upper abdominal pain
• Fatigue
• Joint pain
• Blurred vision
• Gastrointestinal disorder

Sitagliptin and Metformin are two medications that are prescribed to patients with type 2 diabetes. It is vital to follow your physician's instructions and address any concerns you may have regarding these medications. Additionally, here is some general information on these medications to assist you concerning storage: