GLUWIX INJ 40MG/4ML

Furosemide, a potent loop diuretic, primarily acts by inhibiting the reabsorption of sodium and chloride ions in the ascending loop of Henle in the kidneys. This inhibition occurs through the blockade of the Na-K-2Cl cotransporter, a crucial ion channel responsible for the reabsorption of these ions. By inhibiting this transporter, furosemide promotes the excretion of sodium, chloride, and water, leading to increased diuresis. This mechanism effectively reduces extracellular fluid volume, making it particularly useful in conditions where fluid overload is a concern, such as in congestive heart failure, cirrhosis with ascites, and certain kidney disorders. The enhanced diuresis helps to lower blood pressure, reduce edema, and improve cardiac function in patients with cardiovascular diseases.

Furosemide 40mg

Loop diuretic.

Injection

The following are the uses of Furosemide 40mg Injection:

• Used for treating fluid retention (edema) in various conditions such as heart failure, liver disease, or kidney disease.
• Used for reducing swelling and high blood pressure associated with fluid buildup.
• Used for managing hypertension to lower blood pressure.
• Used for rapid removal of excess fluid, especially in emergency situations.
• Used for improving symptoms of congestive heart failure by reducing fluid overload.
• Used for promoting diuresis (increased urine output) during certain medical procedures.
• Used for preventing fluid retention in patients with a history of edema.
• Used for supporting weight loss in severe cases of fluid retention.

In the case of an overdose of Furosemide 40mg Injection, several adverse effects may occur. The symptoms can include excessive urination, dehydration, electrolyte imbalances, and potentially serious cardiovascular issues such as hypotension or arrhythmias. Prompt medical intervention is necessary to manage these symptoms, which may involve rehydration, electrolyte replacement, and close monitoring of vital signs to prevent further complications. It is crucial to seek medical assistance immediately if an overdose is suspected.

In the case of a missed dose of Furosemide 40mg Injection, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this may increase the risk of side effects. If you frequently miss doses, it is advisable to set reminders or use a pill organizer to help you stay on track with your medication regimen. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

To administer Furosemide 40mg Injection, inject the medication slowly into a muscle or vein as directed by your healthcare professional, typically once or twice a day, following the prescribed dosage and duration for your specific medical condition.

Following are the conditions/situations when Furosemide 40mg Injection should not be used:

• Should not be used in patients with known allergy or hypersensitivity to Furosemide or other sulfonamide-derived medications.
• Contraindicated in individuals with severe kidney disease or those who are not producing urine.
• Not suitable for patients with liver disease or severe liver impairment.
• Should not be used if you have low potassium levels (hypokalemia) before treatment.
• Contraindicated during pregnancy, especially in the first and third trimesters, unless the potential benefits outweigh the risks.
• Not recommended for breastfeeding mothers, as Furosemide may pass into breast milk and can cause adverse effects in the nursing infant.
• Avoid if you have a history of severe hearing loss or if you are experiencing hearing loss during treatment.
• Should not be used in individuals with Addison's disease (adrenal gland disorder).

The side effects of Furosemide 40mg Injection may include:

• Low blood pressure (hypotension)
• Electrolyte imbalances, particularly low potassium (hypokalemia) and low sodium (hyponatremia)
• Increased urination
• Dehydration
• Weakness and fatigue
• Dizziness or lightheadedness
• Hearing disturbances, such as ringing in the ears (tinnitus)

Following are the precautions and warnings for Furosemide 40mg Injection:

• This medication should be used with caution in patients with kidney disease or liver impairment, as it may require dosage adjustments and regular monitoring.
• Patients with diabetes should be cautious as Furosemide can affect blood sugar levels. Close monitoring is necessary.
• It may cause an imbalance of electrolytes, particularly low potassium and magnesium levels. Regular blood tests are essential to monitor these levels.
• Elderly patients may be more sensitive to the effects and side effects of this medication.
• Furosemide can cause hearing issues, including ringing in the ears and hearing loss. Discontinue use if these symptoms occur.
• Avoid if allergic to Furosemide or sulfonamide-derived medications.
• This medication may cause dizziness and lightheadedness, especially when standing up from a sitting or lying position. Stand slowly and hold onto support if needed.
• Inform your healthcare provider if you have a history of gout as Furosemide can increase uric acid levels.

Following are the drug interactions for Furosemide 40mg Injection:

• Can reduce the effectiveness of lithium, leading to increased lithium levels and potential toxicity.
• When used with other ototoxic medications like aminoglycoside antibiotics, the risk of hearing damage is heightened.
• May lower blood pressure significantly when combined with antihypertensive drugs, requiring close monitoring.
• Furosemide can decrease the elimination of phenytoin, leading to higher phenytoin levels and potential toxicity.
• The efficacy of furosemide may be reduced by nonsteroidal anti-inflammatory drugs (NSAIDs), which can decrease its diuretic effect.
• When combined with digoxin, furosemide may increase serum digoxin levels, necessitating careful monitoring.
• It can increase the risk of nephrotoxicity when used with cisplatin, requiring dosage adjustments and close observation.

Following are the food interactions for Furosemide 40mg Injection:

• Avoid excessive salt intake, as Furosemide is a diuretic and high salt consumption can reduce its effectiveness.
• Limit foods rich in potassium like bananas, oranges, and tomatoes, as Furosemide may lower potassium levels.
• Monitor vitamin B1 (thiamine) intake, as Furosemide can lead to thiamine deficiency.
• Alcohol should be consumed cautiously as it can increase the risk of dehydration and electrolyte imbalances.
• Avoid licorice, which may decrease the effects of Furosemide by reducing its excretion.
• Grapefruit juice should be used moderately, as it may affect the drug's metabolism.
• A balanced diet is essential to maintain proper nutrition and prevent deficiencies while on Furosemide treatment.
• Always follow the dietary guidelines provided by your healthcare professional for the best outcomes.

Furosemide 40mg Injection should be stored in a secure and controlled environment, preferably in a designated medication storage area. Keep the injections in a cool, dry place, maintaining a temperature between 68°F and 77°F (20°C and 25°C). Protect the injections from direct sunlight, as light exposure may degrade the medication. Ensure the vials are stored in their original packaging to maintain sterility and prevent contamination. Do not freeze the injections as this may affect their potency. When disposing of unused or expired Furosemide injections, do not flush or pour them down the drain. Instead, follow local guidelines for the safe disposal of pharmaceutical waste, or consult a pharmacist or healthcare professional for appropriate disposal methods. Keep the injections out of the reach of children and pets to prevent accidental exposure or ingestion.

Following are the quick tips for Furosemide 40mg Injection:

• Administer the injection under medical supervision as directed by your doctor.
• Ensure the injection is prepared and administered by a trained healthcare professional.
• Follow the prescribed dosage and administration schedule provided by your doctor.
• Inform your doctor if you have any allergies or medical conditions before receiving the injection.
• Report any signs of allergic reactions, such as rash, itching, or difficulty breathing, immediately to your healthcare provider.
• Store the injection as directed on the packaging, typically at room temperature, away from direct sunlight.
• Do not reuse or share needles or syringes to prevent infections and ensure safety.