GLYPRESSIN 1MG INJ

Terlipressin 1MG Injection is a synthetic vasopressin analogue that primarily acts on V1 receptors in the vascular smooth muscle, leading to vasoconstriction. Its mechanism of action involves stimulating vascular smooth muscle contraction, which results in increased peripheral vascular resistance and a rise in blood pressure. This effect is particularly pronounced in the splanchnic circulation, reducing portal pressure and venous capacitance. Terlipressin's V1 receptor agonism also promotes renal water reabsorption, contributing to its ability to improve renal perfusion and reduce urine output.

Terlipressin:

Injection

The following are the uses of Terlipressin 1MG Injection:

• Used for treating low blood pressure in adults with liver failure, helping to improve blood flow and reduce portal hypertension.
• Used for addressing acute bleeding episodes in patients with severe esophageal varices, a life-threatening complication of liver cirrhosis.
• Used for managing hepatorenal syndrome, a kidney disorder related to liver disease, by improving kidney function and reducing the need for dialysis.
• Used for controlling gastrointestinal bleeding due to portal hypertension, effectively reducing bleeding and the risk of rebleeding.
• Used for stabilizing blood pressure during surgical procedures, particularly in liver transplantation, to ensure a safer and more controlled environment.
• Used for supporting critical care management, aiding in maintaining hemodynamic stability in various shock states.
• Used for bridging patients with liver disease to liver transplantation, helping to improve their condition and increase transplant success rates.

In the case of an overdose of Terlipressin 1MG Injection, it is important to recognize the potential severity of the situation. Overdosing on this medication can lead to serious side effects, including hypotension, bradycardia, and gastrointestinal disturbances. Immediate medical intervention is necessary to manage these symptoms and prevent further complications. Promptly contact a healthcare professional or emergency services to ensure appropriate treatment and monitoring.

In the case of a missed dose of Terlipressin 1MG Injection, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for advice on how to proceed and to ensure the medication is still effective. It is recommended to set reminders to help you stay on track with your medication routine.

To administer Terlipressin 1MG Injection, carefully inject the prescribed dose subcutaneously or intravenously as directed by your healthcare professional, ensuring proper aseptic technique and following the recommended dosage guidelines provided by your doctor.

Following are the conditions or circumstances when Terlipressin 1MG Injection should not be administered:

• Must not be used in patients with a known allergy or hypersensitivity to Terlipressin or any other similar medications.
• Contraindicated in individuals with severe cardiovascular diseases, including uncontrolled hypertension, severe coronary artery disease, and recent myocardial infarction.
• Not suitable for patients with severe renal impairment or end-stage kidney disease.
• Should be avoided in patients with advanced liver cirrhosis and portal vein thrombosis.
• Must not be used in patients with a history of intestinal ischemia or ischemic colitis.
• Contraindicated during pregnancy as it may cause harm to the fetus.
• Not recommended for breastfeeding women due to potential risks to the infant.
• Should be used with extreme caution in patients with Raynaud's syndrome or peripheral vascular disease.
• Avoid in patients with a history of recent surgery or gastrointestinal bleeding.
• Not suitable for individuals with a history of severe depression or suicidal ideation.

The side effects of Terlipressin 1MG Injection may include:

• Nausea and vomiting
• Abdominal pain
• Diarrhea
• Headache
• Dizziness
• Increased heart rate (tachycardia)
• Allergic reactions (such as rash, itching, difficulty breathing)
• Pain or discomfort at the injection site

Following are the precautions and warnings for Terlipressin 1MG Injection:

• This medication is intended for intravenous use only and should be administered by trained medical professionals in a clinical setting.
• Terlipressin is contraindicated in patients with a known hypersensitivity or severe allergic reaction to Terlipressin or any of its components.
• Patients with cardiovascular conditions, such as coronary artery disease, arrhythmias, or recent myocardial infarction, should be closely monitored as Terlipressin can affect heart rate and blood pressure.
• It may cause vasoconstriction, so caution is advised in patients with peripheral vascular disease or Raynaud's syndrome.
• Terlipressin can impact kidney function; frequent monitoring of renal function is necessary, especially in patients with pre-existing kidney issues.
• It may cause bradycardia (slow heart rate), so patients with pre-existing cardiac conditions should be closely monitored.
• Not recommended for use in pregnant or breastfeeding women unless the potential benefits outweigh the risks, as determined by a qualified physician.
• Terlipressin should be used with caution in elderly patients as they may be more susceptible to its side effects.

Following are the drug interactions for Terlipressin 1MG Injection:

• Concomitant use with vasopressors like norepinephrine or dopamine may lead to excessive vasoconstriction and potential tissue damage.
• Terlipressin can enhance the effects of other antihypertensive medications, requiring close monitoring of blood pressure.
• The risk of cardiac arrhythmias may increase when used with Class IA and Class III antiarrhythmic agents.
• Drugs that affect renal function, such as NSAIDs or ACE inhibitors, should be used cautiously as Terlipressin may impact renal blood flow.
• It may reduce the effectiveness of diuretics, especially loop diuretics, due to its antidiuretic properties.
• Terlipressin can interact with calcium channel blockers, potentially causing excessive hypotension.
• Close monitoring is necessary when used with other vasoconstrictive agents to avoid severe hypertension.

Following are the food interactions for Terlipressin 1MG Injection:

• Avoid consuming alcohol during the treatment period as it may lead to increased risk of side effects and affect blood pressure.
• Grapefruit and grapefruit juice should be consumed with caution as they can interfere with the breakdown of Terlipressin, potentially leading to increased drug levels in the body.
• Caffeine intake should be monitored as it may elevate blood pressure, especially in patients with hypertension.
• High-sodium foods should be limited as Terlipressin can cause sodium and water retention, and excessive sodium intake may counteract the medication's effects.
• Foods rich in potassium, such as bananas, oranges, and spinach, are beneficial as Terlipressin can cause potassium loss.
• A balanced diet with adequate protein and fluid intake is recommended to support overall health during treatment.
• Avoid heavy meals and high-fat foods as they may affect the absorption and metabolism of Terlipressin.
• Always follow the dietary recommendations provided by your healthcare professional for personalized guidance.

Terlipressin 1MG Injection should be stored in a controlled environment, preferably in a cool and dry place, away from direct sunlight and moisture. The injection should be kept in its original packaging, ensuring the seal remains intact to maintain its sterility. It is crucial to store the medication at room temperature, avoiding exposure to extreme heat or cold. Always check the expiration date on the packaging; do not use the injection if it is past its expiry. When disposing of unused or expired Terlipressin injections, do not throw them into regular trash or pour them down the drain. Contact your local pharmacy or healthcare facility for guidance on safe disposal methods. Keep the medication out of children's reach to prevent accidental exposure or ingestion.

Following are the quick tips for Terlipressin 1MG Injection:

• Ensure you receive this injection under medical supervision for effective treatment.
• Inform your doctor about any allergies or medical conditions before administration.
• Do not self-administer; let trained medical staff handle the injection.
• Mention all medications you are taking to avoid potential interactions.
• Report any side effects like nausea, vomiting, or dizziness to your doctor promptly.
• Store the injection as directed, away from direct sunlight and moisture.
• Regularly monitor your blood pressure and kidney function while on this medication.
• Do not miss scheduled follow-ups to assess treatment progress.