Glyrate (2.6mg) 30 Tablets

Glyceryl Trinitrate, commonly known as nitroglycerin, acts primarily by releasing nitric oxide (NO) into the bloodstream. When administered, it rapidly metabolizes to generate NO, which is a potent vasodilator. This mechanism of action is crucial as it leads to the relaxation of vascular smooth muscles, particularly in the veins and arteries. The release of nitric oxide causes smooth muscle cells to relax, resulting in vasodilation, which lowers systemic vascular resistance and reduces the workload on the heart. This effect is particularly beneficial in conditions where blood vessels are constricted or in cases of high blood pressure, as it helps improve blood flow and reduces the oxygen demand of the heart.

Glyceryl Trinitrate 2.6mg

vasodilator

Tablet

The following are the uses of Glyceryl Trinitrate 2.6mg Tablet:

• Used for managing and relieving angina attacks.
• Used to treat heart failure, helping to reduce strain on the heart.
• Used in emergency situations to manage acute heart failure.
• Effective in lowering blood pressure during certain medical procedures.
• Can be used to manage severe hypertension.
• Provides rapid relief for chest pain associated with coronary artery disease.
• Assists in reducing the workload on the heart after a heart attack.

In the case of an overdose of Glyceryl Trinitrate 2.6mg Tablets, individuals may experience severe headaches, dizziness, and a sudden drop in blood pressure. This can lead to lightheadedness, fainting, and even cardiac issues. Promptly seek medical assistance if you suspect an overdose, as it may require immediate intervention to stabilize blood pressure and manage symptoms. Timely action is vital to ensure the patient's well-being and prevent potential complications.

In the case of a missed dose of Glyceryl Trinitrate 2.6mg Tablet, it is important to take the dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare provider for advice on how to safely resume your medication and maintain its effectiveness.

To use Glyceryl Trinitrate 2.6mg Tablets, place the tablet under your tongue and allow it to dissolve completely, preferably without swallowing, as this helps the medication absorb quickly into the bloodstream.

Following are the conditions/situations when Glyceryl Trinitrate 2.6mg Tablet should not be used:

• Should not be used in individuals with a known allergy to nitrates or any other components of the medication.
• Contraindicated in patients with severe anemia, as it can worsen oxygen supply to vital organs.
• Not recommended for individuals with recent head trauma or increased intracranial pressure.
• Should not be used in patients with heart conditions such as severe aortic stenosis or hypertrophic obstructive cardiomyopathy.
• Contraindicated during acute myocardial infarction (heart attack) with low blood pressure and impaired cardiac filling.
• Not suitable for individuals with recent stroke or cerebral hemorrhage.
• Should be avoided in patients with severe hypotension (very low blood pressure) as it can further lower blood pressure to dangerous levels.

The side effects of Glyceryl Trinitrate 2.6mg Tablet may include:

• Severe headaches or migraines.
• Dizziness or lightheadedness, which may lead to fainting.
• Palpitations or increased heart rate.
• Flushing or feeling of warmth in the face and chest.
• Nausea and vomiting.
• Skin rashes or itching.
• Hypotension (low blood pressure) with symptoms like weakness and fatigue.

Following are the precautions and warnings for Glyceryl Trinitrate 2.6mg Tablet:

• Do not take this medication if you are allergic to glyceryl trinitrate or similar medications.
• If you have a history of heart disease, low blood pressure, or recent heart attack, use with caution and under medical supervision.
• Avoid consuming alcohol while taking this medication as it may cause a sudden drop in blood pressure.
• Headaches are a common side effect; inform your doctor if they are severe or persistent.
• Do not drive or operate heavy machinery if you experience dizziness or lightheadedness after taking this tablet.
• This medication may not be suitable for pregnant or breastfeeding women; consult your doctor for advice.
• Keep out of reach of children and pets; accidental ingestion can be harmful.
• Store in a cool, dry place, away from direct sunlight and moisture.

Following are the drug interactions for Glyceryl Trinitrate 2.6mg Tablet:

• Phosphodiesterase inhibitors, such as sildenafil, tadalafil, and vardenafil, can significantly increase the hypotensive effects of glyceryl trinitrate, leading to a sudden drop in blood pressure.
• Alcohol consumption can potentiate the vasodilatory effects of this drug, resulting in excessive blood pressure lowering.
• Beta-blockers, including metoprolol and propranolol, may reduce the effectiveness of glyceryl trinitrate by preventing its vasodilatory action.
• Calcium channel blockers like amlodipine and verapamil can enhance the hypotensive effects, requiring careful monitoring.
• When combined with other antihypertensive medications, such as ACE inhibitors or diuretics, blood pressure may drop excessively.
• Medications that affect platelet function, including aspirin and clopidogrel, could increase bleeding risk when used with glyceryl trinitrate.
• Ergot derivatives, for example, ergotamine, should be avoided due to the potential for ergot toxicity and severe vasoconstriction.

Following are the food interactions with Glyceryl Trinitrate 2.6mg Tablet:

• Alcohol consumption should be avoided as it may increase the blood pressure-lowering effect of the medication, leading to potential dizziness and lightheadedness.
• Grapefruit and grapefruit juice are to be avoided as they can decrease the breakdown of the drug, resulting in increased levels of Glyceryl Trinitrate in the body and potentially causing severe headaches and low blood pressure.
• Caffeine intake should be monitored as it may counteract the medication's effects, reducing its effectiveness in treating chest pain.
• Avoid high-fat meals as they may delay the absorption of the drug, potentially reducing its effectiveness.
• Garlic, a natural blood thinner, can increase the anti-platelet effects of the medication, requiring close monitoring.
• Licorice may inhibit the enzyme responsible for breaking down Glyceryl Trinitrate, leading to increased medication levels in the body.
• Food rich in tyramine, like aged cheeses, cured meats, and fermented foods, should be limited as they may interact with the medication and increase blood pressure.
• Avoid large meals immediately after taking the tablet to ensure optimal absorption and effectiveness.

Glyceryl Trinitrate 2.6mg Tablets should be stored in a cool, dry place, preferably at room temperature between 15-25°C (59-77°F). Protect the tablets from direct sunlight, moisture, and heat, as these conditions can degrade the medication. Keep the container tightly sealed to maintain its integrity and prevent exposure to air. It is crucial to adhere to the recommended storage conditions to ensure the effectiveness and stability of the tablets. When disposing of unused or expired medication, avoid flushing or pouring it down the drain. Contact your pharmacist or local waste management authorities for guidance on proper disposal methods, ensuring environmental safety. Keep the tablets out of the reach of children and pets to prevent accidental ingestion, which could be harmful.

Following are the quick tips for Glyceryl Trinitrate 2.6mg Tablet:

• Consult a doctor for a personalized prescription and dosage instructions.
• Ensure you understand the purpose and duration of the medication.
• Take the tablet as directed, usually under the tongue or between the cheek and gum.
• Allow the tablet to dissolve completely without chewing or swallowing it.
• Avoid drinking hot beverages immediately after taking the tablet.
• Store the tablets in their original packaging at room temperature, away from direct sunlight.
• Inform your doctor about any other medications you are taking to prevent interactions.
• Seek immediate medical attention if you experience severe headaches, dizziness, or chest pain.