Gonapan-DF 60ml Suspension

Gonapan-DF 60ml Suspension

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  • Manufacturer REKO PHARMACEUTICALS (PVT.) LTD.
  • Generic Name Diloxanide Furoate, Metronidazole

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Diloxanide Furoate acts by interfering with the energy metabolism of amoebic trophozoites, leading to their elimination. It is specifically effective against Entamoeba histolytica, the causative agent of amoebiasis. Metronidazole, on the other hand, is an antiprotozoal agent that works by disrupting the DNA synthesis of anaerobic organisms, including amoebic and giardial trophozoites. It is rapidly absorbed and selectively taken up by anaerobic organisms, causing their destruction. When combined, these two active ingredients provide a synergistic effect in treating intestinal amoebiasis and other protozoal infections.

  • Ingredients

    Diloxanide Furoate, Metronidazole
  • Drug Class

    Antiparasitic, Antibiotic

  • Dosage Form

    Suspension

  • Uses

    The following are the uses of Diloxanide Furoate 500mg, Metronidazole 400mg Syrup/Suspension:

    • Used for treating intestinal amoebiasis, effectively eliminating amoebic parasites from the digestive system.
    • Used to address infections caused by Giardia, a common intestinal parasite.
    • Used to manage and alleviate symptoms associated with amoebic dysentery, including diarrhea, abdominal pain, and intestinal inflammation.
    • Used as a second-line treatment for Helicobacter pylori infections, often in combination with other medications.
    • Used for preventing the recurrence of amoebic infections in individuals who have been previously infected.
    • Used to improve gastrointestinal health by eradicating harmful parasites and promoting a healthy gut environment.
    • Used as an adjunct therapy for inflammatory bowel diseases, reducing the risk of parasitic complications.
  • In case of Overdose

    In the case of an overdose of Diloxanide Furoate 500mg or Metronidazole 400mg Syrup/Suspension, seek medical advice promptly. Symptoms may include nausea, vomiting, dizziness, and in severe cases, seizures or loss of consciousness. Quick action is vital; contact a healthcare professional or go to the nearest emergency room. Treatment may involve supportive care and managing symptoms until the medication is cleared from the system.

  • Missed Dose

    In the case of a missed dose of Diloxanide Furoate 500mg, take it as soon as you remember, unless it's almost time for your next dose. You can then continue with your regular dosing schedule. For Metronidazole 400mg Syrup/Suspension, if a dose is missed, take it as soon as possible, but if it's close to the time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose to make up for a missed one.

  • How To Use

    To administer Diloxanide Furoate 500mg and Metronidazole 400mg syrup/suspension, shake the bottle well, then use the provided measuring device to draw the prescribed amount, and take it orally as directed by your healthcare provider, typically twice a day, regardless of meals, following the dosage instructions precisely.

  • When Not to Use

    Following are the conditions/situations when Diloxanide Furoate 500mg and Metronidazole 400mg Syrup/Suspension should not be used:

    • Avoid if allergic to any of the active ingredients or similar medications.
    • Not suitable for individuals with a history of hypersensitivity reactions to furan derivatives.
    • Contraindicated in patients with severe liver impairment or severe kidney disease.
    • Should not be used if you have a central nervous system disease or severe chronic disease.
    • Avoid if you have a blood disorder or significant gastrointestinal disease.
    • Not recommended for individuals with a history of seizures or epilepsy.
    • Do not use if you have a history of porphyria (a disorder affecting certain enzymes in the body).
    • Contraindicated during the first trimester of pregnancy and in breastfeeding mothers.
  • Side Effects

    The side effects of Diloxanide Furoate 500mg and Metronidazole 400mg Syrup/Suspension may include:

    • Nausea and vomiting
    • Loss of appetite
    • Darkening of urine
    • Metallic taste in the mouth
    • Diarrhea or constipation
    • Dizziness or headache
    • Skin rashes or itching
  • Precautions & Warnings

    Following are the precautions and warnings for Diloxanide Furoate 500mg, Metronidazole 400mg Syrup/Suspension:

    • Avoid in patients with known hypersensitivity to diloxanide furoate or metronidazole or any other components of the medication.
    • Use with caution in patients with liver or kidney disease, as these conditions may affect drug metabolism and clearance.
    • Avoid alcohol consumption during treatment as it may cause a disulfiram-like reaction with metronidazole, leading to nausea, vomiting, and abdominal pain.
    • This medication may cause dizziness and drowsiness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
    • Long-term use of metronidazole may lead to neurological side effects; regular monitoring is necessary.
    • Not recommended for use in pregnant or breastfeeding women unless the potential benefits outweigh the risks.
    • Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.
    • Always complete the full course of treatment, even if symptoms improve, to ensure complete eradication of the infection.
  • Drug Interactions

    Following are the drug interactions for Diloxanide Furoate 500mg and Metronidazole 400mg Syrup/Suspension:

    • Alcohol should be avoided as it may cause increased gastrointestinal side effects and altered liver metabolism.
    • Concomitant use with warfarin or other anticoagulants may increase the risk of bleeding.
    • Phenytoin levels may be altered, so monitoring is necessary during co-administration.
    • Lithium levels may be affected, requiring close observation for toxicity.
    • Drugs metabolized by CYP450 enzymes may have altered metabolism, requiring dosage adjustments.
    • Prolonged use with disulfiram may lead to psychotic reactions.
    • Metronidazole may decrease the effectiveness of oral contraceptives, requiring additional contraceptive measures.
    • The absorption of Diloxanide Furoate may be reduced by antacids, requiring separate administration.
  • Food Interactions

    Following are the food interactions for Diloxanide Furoate 500mg and Metronidazole 400mg Syrup/Suspension:

    • Avoid consuming alcohol during and a few days after the treatment with Metronidazole, as it can cause a disulfiram-like reaction with symptoms like flushing, headache, nausea, and increased heart rate.
    • Grapefruit juice should be avoided with Metronidazole as it can decrease the drug's metabolism and potentially increase the risk of side effects.
    • Diloxanide Furoate may cause a temporary metallic taste, so it's best to avoid strong-flavored foods and drinks to minimize this effect.
    • Consuming a full meal with a high-fat content may reduce the absorption of Metronidazole, so it's advisable to take the medication on an empty stomach or with a light meal.
    • Avoid dairy products, especially milk, as they can interfere with the absorption of Diloxanide Furoate, reducing its effectiveness.
    • Foods rich in Vitamin C, like citrus fruits and their juices, should be consumed with caution as they can potentially reduce the effectiveness of Metronidazole.
    • Avoid sugary foods and beverages as they can promote the growth of bacteria and reduce the effectiveness of the antibiotic Metronidazole.
    • There are no specific food restrictions for Diloxanide Furoate, but maintaining a balanced diet is recommended to support overall health during treatment.
  • Storage/Disposal

    Diloxanide Furoate 500mg and Metronidazole 400mg Syrup/Suspension should be stored in a controlled environment, maintaining a cool temperature between 20-25°C (68-77°F) and away from direct sunlight. Keep the medication in its original container, tightly sealed, to ensure its integrity and prevent contamination. It is crucial to avoid exposing the medication to moisture, heat, or freezing temperatures, as this can compromise its effectiveness. Dispose of any unused or expired medication responsibly; do not flush it or pour it down the drain. Consult your pharmacist or healthcare provider for specific instructions on proper disposal methods in your area. Keep the medication out of children's reach to prevent accidental ingestion, and always check the expiration date before use.

  • Quick Tips, if any

    Following are the quick tips for Diloxanide Furoate 500mg and Metronidazole 400mg Syrup/Suspension:

    • Always follow the dosage instructions provided by your doctor or pharmacist.
    • Shake the bottle vigorously before each use to ensure proper mixing.
    • Administer the syrup with a sufficient amount of water for better effectiveness.
    • Maintain consistency by taking the medication at the same time daily.
    • Consider taking it with meals to reduce potential gastrointestinal issues.
    • Store the medication safely, away from children's reach.
    • Avoid mixing with tea, coffee, or dairy products as they may interfere with absorption.
    • Consult your healthcare provider if you have any concerns or experience unusual symptoms.

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