GRANDAXIN TAB

Tofisopam's primary mechanism of action is distinct from traditional benzodiazepines. It acts as a full agonist at the mitochondrial 18 kDa translocator protein (TSPO), formerly known as the peripheral benzodiazepine receptor. By binding to TSPO, Tofisopam modulates the activity of steroidogenic enzymes involved in the biosynthesis of neuroactive steroids, such as allopregnanolone, which are positive allosteric modulators of GABAA receptors. This indirect enhancement of GABAergic neurotransmission contributes to Tofisopam's anxiolytic effects without causing sedation or the development of tolerance associated with conventional benzodiazepines. Additionally, Tofisopam has been shown to interact with serotonin receptors, particularly the 5-HT1A receptor, which may also contribute to its therapeutic actions.

Benzodiazepine-like anxiolytic

Tablet

The following are the uses of Tofisopam Tablet:

• Used for managing anxiety and tension, offering quick relief without causing drowsiness.
• Used for treating symptoms like nervousness, stress, and irritability.
• Used for reducing physical symptoms of anxiety, including muscle tension and restlessness.
• Used for improving sleep quality and promoting relaxation without impairing daytime performance.
• Used for providing short-term relief from situational anxiety, such as before exams or job interviews.
• Used for managing anxiety disorders when other treatments are not suitable or effective.
• Used for assisting in anxiety-related conditions like panic disorder or generalized anxiety disorder.
• Used for supporting overall well-being by alleviating anxiety-related symptoms and improving quality of life.

In the case of an overdose of Tofisopam Tablets, several symptoms may occur, including drowsiness, confusion, and in severe cases, respiratory depression. Immediate medical attention is required, and the patient should be monitored for vital signs and potential complications. Treatment involves supportive care, such as ensuring airway patency and maintaining adequate ventilation. It is crucial to seek emergency help and provide healthcare professionals with information about the quantity ingested and the time of overdose to facilitate effective management.

In the case of a missed dose of Tofisopam Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Avoid taking a double dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. It's important to consult your healthcare provider if you have any concerns or if you miss multiple doses.

To take Tofisopam tablets, swallow the tablet whole with a glass of water, preferably in the morning or as directed by your doctor, and follow the prescribed dosage and treatment duration without altering or discontinuing the medication.

Here are the situations when Tofisopam Tablet should not be used:

• Avoid if you have a known allergy or hypersensitivity to Tofisopam or other similar medications.
• Not recommended for individuals with severe liver or kidney impairment.
• Contraindicated in patients with acute angle-closure glaucoma.
• Should not be used in patients with a history of substance abuse or dependence.
• Not suitable for children and adolescents under 18 years of age.
• Avoid if you have a history of severe cardiovascular disease or conditions like myocardial infarction.
• Do not use if you have a history of respiratory depression or severe respiratory conditions.
• Contraindicated during breastfeeding as it may pass into breast milk.
• Not recommended for individuals with a history of seizures or epilepsy.

The side effects of Tofisopam Tablet may include:

• Dizziness
• Headache
• Sleep disturbances (insomnia or drowsiness)
• Fatigue
• Gastrointestinal issues (nausea, diarrhea, or dry mouth)
• Skin rashes or itching
• Changes in appetite
• Confusion or concentration difficulties

Following are the precautions and warnings for Tofisopam Tablet:

• Not recommended for individuals with a known hypersensitivity or allergy to Tofisopam or any of its ingredients.
• Patients with a history of liver or kidney disease should exercise caution and consult a doctor, as dosage adjustments might be necessary.
• Tofisopam may cause drowsiness or dizziness, so patients should avoid driving, operating heavy machinery, or engaging in activities requiring mental alertness until they know how the medication affects them.
• Elderly patients may be more susceptible to the side effects of Tofisopam, hence, regular monitoring is advised.
• This medication should be used with caution in patients with a history of depression or suicidal thoughts, and any such symptoms should be reported to the doctor immediately.
• The use of Tofisopam during pregnancy and breastfeeding should be carefully considered and discussed with a healthcare professional, as the potential risks and benefits should be weighed.
• Tofisopam should be used with caution in combination with other central nervous system depressants, as it may enhance their effects and increase the risk of side effects.

Following are the drug interactions for Tofisopam Tablet:

• Alcohol consumption should be avoided as it may enhance the sedative effects of Tofisopam.
• Tofisopam may increase the sedative effects of other central nervous system depressants like benzodiazepines, barbiturates, and opioids.
• It can interact with other drugs metabolized by the liver, potentially affecting the levels of medications like warfarin, phenytoin, and carbamazepine.
• Antacids may reduce the absorption of Tofisopam, so they should be taken at least 2 hours apart.
• The effectiveness of hormonal contraceptives may be reduced, so alternative contraceptive methods are recommended.
• Drugs that induce or inhibit liver enzymes (e.g., rifampicin, ketoconazole) can alter Tofisopam metabolism.
• It may have additive effects when used with other anxiolytics or sedatives, requiring close monitoring.

Following are the food interactions for Tofisopam Tablet:

• Tofisopam may interact with alcohol, leading to increased drowsiness and sedation. It is advisable to avoid or limit alcohol consumption during treatment.
• Grapefruit and grapefruit juice should be consumed with caution as they can influence the metabolism of Tofisopam, potentially affecting its effectiveness.
• High-fat meals may delay the absorption of Tofisopam, resulting in a slightly slower onset of action.
• Caffeine-rich beverages like coffee and energy drinks might enhance the stimulating effects of Tofisopam, potentially causing restlessness or anxiety.
• Spicy foods, while not directly interacting with Tofisopam, can potentially exacerbate gastrointestinal side effects in some individuals.
• Avoid consuming large amounts of chocolate, as it contains a compound that can inhibit the metabolism of Tofisopam, leading to increased drug levels in the body.
• Some herbal teas, particularly those containing St. John's Wort, may affect the metabolism of Tofisopam, and should be used with caution.
• It's best to maintain a balanced diet, as extreme dietary changes may influence the overall effectiveness of Tofisopam.

Tofisopam tablets should be stored in a cool and dry place, preferably at room temperature, away from direct exposure to sunlight, heat, and moisture. The original container should be used to keep the tablets protected and to ensure their integrity. It is crucial not to store them in the bathroom or kitchen, as these areas can be prone to temperature fluctuations. Always check the expiration date, and do not use the medication if it has passed its expiry. When disposing of unused or expired tablets, do not flush them or throw them into the trash. Contact your pharmacist or local waste management authority for guidance on safe disposal practices to prevent environmental contamination. Keep the medication securely locked away from children and pets to prevent accidental consumption.

Following are the quick tips for Tofisopam Tablet:

• Take the tablet as directed by your doctor, typically 2 to 3 times a day.
• Swallow the tablet whole with a glass of water; do not crush or chew it.
• Tofisopam can be taken with or without food, but taking it with food may reduce stomach upset.
• Avoid alcohol consumption while taking this medication as it may enhance sedative effects.
• Do not drive or operate heavy machinery until you know how Tofisopam affects you.
• Inform your doctor about all medications you are taking to avoid potential drug interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.