GRASTIN INJ 300UG

Filgrastim's primary mechanism of action is to stimulate the production and release of neutrophils, a type of white blood cell, from the bone marrow. It is a recombinant form of human granulocyte colony-stimulating factor (G-CSF), a naturally occurring protein that regulates the production and maturation of neutrophils. Filgrastim binds to specific G-CSF receptors on hematopoietic stem cells, primarily located in the bone marrow. This binding triggers a cascade of intracellular signals that promote the proliferation, differentiation, and maturation of neutrophil precursors. The result is an increased production of neutrophils, which are essential for fighting infections, particularly in individuals with neutropenia or those undergoing chemotherapy, as it helps to restore neutrophil counts and enhance immune function.

Filgrastim

Granulocyte colony-stimulating factor.

Injection

The following are the uses of Filgrastim Injection:

• Used for boosting the production of white blood cells in patients undergoing chemotherapy, helping them fight infections.
• Used for treating neutropenia, a condition with low white blood cell counts, to prevent infections.
• Used for mobilizing stem cells from the bone marrow into the bloodstream for collection and transplantation.
• Used for accelerating recovery from neutropenia after a bone marrow transplant.
• Used for reducing the duration and severity of neutropenia in patients with advanced HIV infection.
• Used for managing congenital neutropenia and cyclic neutropenia, rare genetic disorders affecting white blood cell production.
• Used for enhancing immune response in certain medical conditions requiring increased white blood cell activity.
• Used for improving wound healing in patients with severe trauma or burns by promoting white blood cell function.

In the case of an overdose of Filgrastim Injection, prompt medical attention is required. Symptoms may include bone pain, severe headache, shortness of breath, and allergic reactions such as rash or itching. Seek emergency care if you suspect an overdose, as medical professionals can provide necessary interventions to manage symptoms and prevent potential complications. It is crucial to act swiftly and inform healthcare providers of the situation.

In the case of a missed dose of Filgrastim Injection, it is important to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, it is recommended to skip the missed dose and continue with the regular dosing schedule. Do not administer a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your dosing schedule and ensure the medication's effectiveness.

To administer the Filgrastim injection, clean the injection site with an alcohol swab, insert the needle at a 45-degree angle, inject the medication slowly, and then gently remove the needle while applying pressure to the site with a sterile cotton ball for a few seconds.

Following are the conditions when Filgrastim Injection should not be used:

• Do not use if you are allergic to Filgrastim or other colony-stimulating factors.
• Avoid if you have a history of hypersensitivity reactions to proteins derived from E. coli.
• Should not be administered if you have a sickle cell disorder or sickle cell trait.
• Not recommended for individuals with chronic myeloid leukemia who are in blast crisis.
• Do not use if you have a serious infection without concurrent antibiotic treatment.
• Contraindicated in patients with a known sensitivity to benzyl alcohol, which is used as a preservative in the injection.
• Do not use in patients with myelodysplastic syndromes (MDS) who have a chromosomal abnormality that predicts evolution to acute myelogenous leukemia.

The side effects of Filgrastim Injection may include:

• Bone pain
• Headache
• Fatigue
• Joint pain
• Nausea and vomiting
• Diarrhea
• Mild skin rash or itching
• Fever

Following are the precautions and warnings for Filgrastim Injection:

• Do not use if you are allergic to Filgrastim or any of its components; severe allergic reactions may occur.
• Monitor blood cell counts regularly during treatment, as Filgrastim can affect white blood cell production.
• Patients with a history of chronic myeloid leukemia or myelodysplastic syndrome should use with caution and under medical supervision.
• Discontinue use if you experience shortness of breath, chest pain, or allergic reactions after injection.
• Exercise caution in patients with kidney disease, as Filgrastim may need dosage adjustments.
• Not recommended for use during pregnancy or breastfeeding; consult your doctor for alternative options.
• If you have had recent chemotherapy or radiation therapy, inform your doctor, as it may impact the use of Filgrastim.

Following are the drug interactions for Filgrastim Injection:

• Concomitant use with other colony-stimulating factors like sargramostim may lead to an increased risk of hematologic abnormalities.
• The use of Filgrastim with chemotherapy agents can enhance the myelosuppressive effects of these drugs, requiring careful monitoring of blood counts.
• It may interact with immunosuppressants, as Filgrastim can counteract their effects, potentially reducing the desired immunosuppression.
• When used with radiopharmaceuticals, Filgrastim may alter the distribution and clearance of these agents, affecting their diagnostic or therapeutic efficacy.
• Corticosteroids might decrease the effectiveness of Filgrastim, as they can suppress the immune response and bone marrow function.
• Antineoplastic agents can increase the risk of myelosuppression, and Filgrastim should be used cautiously to avoid potential hematologic adverse effects.
• Certain medications that affect bone marrow function, such as azathioprine or methotrexate, may require dose adjustments when used with Filgrastim.

Following are the food interactions for Filgrastim Injection:

• Filgrastim can be taken with or without food, but maintaining a consistent schedule with meals is recommended to ensure optimal absorption.
• Avoid alcohol consumption as it may interfere with the medication's effectiveness and increase the risk of side effects.
• Grapefruit and grapefruit juice should be consumed with caution as they may alter the drug's metabolism, potentially leading to increased blood levels of Filgrastim.
• Caffeinated beverages may decrease the absorption of Filgrastim, so it is advisable to limit or avoid these drinks around the time of medication intake.
• High-fat meals can potentially delay the absorption of Filgrastim, so it is best to avoid consuming large amounts of fatty foods shortly before or after taking the injection.
• Certain foods rich in antioxidants, such as berries, spinach, and nuts, may enhance the immune-boosting effects of Filgrastim, so including these in your diet could be beneficial.
• Maintain a balanced diet with adequate protein and calorie intake to support the body's response to Filgrastim and overall health during treatment.
• Stay hydrated by drinking plenty of water to ensure proper circulation and distribution of the medication throughout the body.

Filgrastim Injection should be stored in a refrigerator at a temperature between 2°C to 8°C (36°F to 46°F). It is crucial to keep the injection in its original packaging to protect it from light and moisture. Do not freeze the medication as it may affect its potency. If the injection has been stored at room temperature, it must be used within a specified time frame as directed by the manufacturer, typically within a few days. Once the injection is removed from the refrigerator, it should be allowed to reach room temperature before administration. After use, any remaining medication should be properly disposed of according to local guidelines for pharmaceutical waste disposal. This ensures the safe and effective management of the medication and minimizes environmental impact. It is important to keep Filgrastim Injection out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Filgrastim Injection:

• Ensure the injection is administered by a trained healthcare professional.
• Inform your doctor about any allergies or medications you are taking.
• Store the injection as directed on the packaging, usually in the refrigerator.
• Do not use if the solution appears discolored or contains particles.
• Rotate injection sites to minimize skin irritation.
• Dispose of used needles and syringes safely in designated sharps containers.
• Report any side effects or unusual symptoms to your healthcare provider promptly.
• Follow your doctor's instructions for the duration of treatment.