GRIVIN ORAL SUSP 120ML

Griseofulvin, the active ingredient in Griseofulvin Syrup/Suspension, has a unique mechanism of action that primarily targets fungal infections. It interferes with microtubule function in fungal cells, disrupting their ability to undergo mitosis and cell division. Griseofulvin binds to tubulin, a protein subunit of microtubules, causing structural changes that inhibit the assembly and disassembly dynamics of the microtubule network. This disruption leads to impaired cell division and ultimately results in the inhibition of fungal growth. By specifically targeting the microtubule system, Griseofulvin exhibits its antifungal activity without significantly affecting mammalian cells, making it an effective treatment option for certain types of fungal infections.

Griseofulvin

Antifungal, griseofulvin derivative

Suspension

The following are the uses of Griseofulvin Syrup/Suspension:

• Used for treating fungal infections of the skin, hair, and nails, particularly those caused by Trichophyton species.
• Used for controlling the spread of infection and improving symptoms like itching and scaling.
• Used for treating ringworm infections, such as athlete's foot, jock itch, and ringworm of the scalp or beard.
• Used for its ability to interfere with fungal cell division and inhibit fungal growth.
• Used for children and adults, with dosage determined by body weight and response to treatment.
• Used for a limited duration, typically 2-4 weeks for skin infections and 6-8 weeks for scalp or nail infections.
• Used for maximum effectiveness when combined with good hygiene practices and keeping the affected area clean and dry.

In the case of an overdose of Griseofulvin Syrup/Suspension, the severity of symptoms can vary. Common signs include nausea, vomiting, and skin rashes. More serious effects might involve liver issues, allergic reactions, or neurological symptoms like dizziness and confusion. Prompt medical care is necessary, and healthcare professionals should be informed about the amount ingested and any symptoms observed to ensure appropriate treatment and management of potential complications.

In the case of a missed dose of Griseofulvin Syrup/Suspension, it is important to take the medication as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one. It is crucial to maintain a consistent level of the medication in your system, so try to take it at the same time each day. If you frequently miss doses, consult your healthcare provider for advice on how to improve your medication adherence.

To administer Griseofulvin Syrup/Suspension, shake the bottle well, measure the prescribed dose with an accurate measuring device, and take it orally, as directed by your healthcare provider, either with or without food, following the recommended dosage instructions for your age and condition.

Here are the conditions or situations when Griseofulvin Syrup/Suspension should not be used:

• Avoid using in patients with known hypersensitivity or allergy to Griseofulvin or related antifungal medications.
• Not suitable for individuals with severe liver disease, as it may cause further liver damage.
• Contraindicated in pregnant women due to potential risks to the fetus.
• Should not be administered to breastfeeding mothers, as it can pass into breast milk.
• Avoid using in children under two years of age due to potential side effects.
• Not recommended for individuals with severe blood disorders, such as aplastic anemia.
• Should not be used by patients with a history of severe skin reactions to medications.
• Contraindicated in patients with porphyria, a disorder affecting the skin and nervous system.
• Not suitable for long-term use due to potential risks of bone marrow suppression.

The side effects of Griseofulvin Syrup/Suspension may include:

• Headache
• Nausea and vomiting
• Diarrhea
• Loss of appetite
• Skin rash or itching
• Sensitivity to sunlight (photosensitivity)
• Taste disturbance
• Liver problems (rare)

Following are the precautions and warnings for Griseofulvin Syrup/Suspension:

• Avoid using this medication if you are allergic to Griseofulvin or any other similar antifungal drugs.
• Griseofulvin may cause liver damage; regular monitoring of liver function is necessary during treatment.
• It can make your skin more sensitive to sunlight; limit sun exposure and use protective measures when outdoors.
• This medication should be used with caution in patients with a history of kidney or liver disease, as it may affect these organs.
• Do not consume alcohol while taking Griseofulvin as it can increase the risk of liver damage.
• Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as Griseofulvin may harm the fetus or infant.
• Children should use this medication under strict medical supervision due to potential adverse effects on bone and teeth development.
• Griseofulvin may interact with other medications; inform your doctor about all the medicines you are taking to prevent any adverse interactions.

Following are the drug interactions for Griseofulvin Syrup/Suspension:

• Alcohol may reduce the effectiveness of Griseofulvin, and it is advised to avoid or limit alcohol consumption during treatment.
• It can interact with anticoagulants like warfarin, leading to an increased risk of bleeding. Regular monitoring is necessary.
• The effectiveness of oral contraceptives may be reduced, requiring additional contraceptive measures.
• Barbiturates can decrease the levels of Griseofulvin, potentially reducing its antifungal activity.
• Carbamazepine and phenytoin may decrease Griseofulvin levels, requiring close monitoring.
• Antacids containing aluminum or magnesium can reduce the absorption of Griseofulvin, and should be taken at separate times.
• The syrup form may contain sugar, which is important for patients with diabetes, as it can affect blood sugar levels.

Following are the food interactions for Griseofulvin Syrup/Suspension:

• Alcohol intake should be avoided as it can decrease the effectiveness of Griseofulvin and may increase the risk of liver damage.
• Grapefruit and grapefruit juice consumption should be avoided as they can increase the levels of Griseofulvin in the blood, leading to potential toxicity.
• High-fat meals can reduce the absorption of Griseofulvin, so it is best to take the medication on an empty stomach or with a light meal.
• Dairy products like milk, cheese, and yogurt may interfere with the absorption of Griseofulvin, so it is advisable to separate them by a few hours.
• Avoid eating charcoal-grilled foods as they can reduce the effectiveness of Griseofulvin.
• Vitamin supplements, particularly those containing Vitamin A, should be used with caution as Griseofulvin can increase Vitamin A levels in the body.
• Certain foods rich in Vitamin A, such as liver, should be consumed in moderation to prevent excessive Vitamin A levels.
• Always follow the advice of your healthcare provider regarding dietary restrictions and medication timing for optimal results.

Griseofulvin Syrup/Suspension should be stored in a secure location, preferably a locked medicine cabinet, away from direct sunlight, heat, and moisture. Maintain a consistent room temperature to preserve its effectiveness. Always keep the medication in its original container, tightly sealed, to prevent contamination and accidental ingestion, especially by children. Dispose of any unused or expired syrup responsibly; do not pour it down the drain or flush it, as it can harm the environment. Consult your pharmacist or local waste management authority for guidance on safe disposal practices to protect both your community and the environment.

Following are the quick tips for Griseofulvin Syrup/Suspension:

• Administer the correct dose as prescribed by your doctor or pharmacist.
• Measure the dose accurately using the measuring cup provided.
• Take the syrup orally, and ensure it is swallowed completely.
• It can be taken with or without food, but taking it with a meal may reduce stomach irritation.
• Avoid consuming alcohol while taking this medication as it may interfere with its effectiveness.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Always check the expiration date before using the medication.