GTN CREAM 25GM

Glyceryl Trinitrate (GTN) cream exhibits its therapeutic effects through the release of nitric oxide (NO) upon dermal absorption. Nitric oxide is a potent vasodilator, meaning it relaxes and widens blood vessels by promoting the production of cyclic guanosine monophosphate (cGMP). This relaxation occurs due to the activation of soluble guanylyl cyclase in vascular smooth muscle cells, leading to reduced intracellular calcium levels and subsequent smooth muscle relaxation. By dilating the blood vessels, GTN cream improves blood flow and enhances oxygen delivery to tissues, which is particularly beneficial in conditions where increased blood flow is desired, such as in the treatment of certain cardiovascular disorders. The localized release of NO from the cream ensures a targeted therapeutic effect with minimal systemic side effects.

Glyceryl Trinitrate

Nitrate vasodilator

Cream

The following are the uses of Glyceryl Trinitrate Cream:

• Used for treating Angina, a type of chest pain caused by reduced blood flow to the heart.
• Used for relieving symptoms of chest pain and improving blood flow to the heart muscle.
• Used for preventing and managing angina attacks.
• Used for reducing the frequency and severity of angina episodes.
• Used for improving exercise tolerance in patients with stable angina.
• Used for providing temporary relief from angina symptoms during activities or situations that typically trigger pain.
• Used for as a short-term treatment option to manage acute angina episodes.

In the case of an overdose of Glyceryl Trinitrate Cream, it is important to recognize the potential symptoms such as severe headaches, dizziness, and a sudden drop in blood pressure. If an overdose is suspected, promptly remove any remaining cream from the skin and seek medical advice. A healthcare professional should be contacted immediately for guidance and further treatment, as they can provide specific instructions based on the individual's condition.

In the case of a missed dose of Glyceryl Trinitrate Cream, it is important to apply the cream as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular application schedule. Do not apply extra cream to make up for the missed dose, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a medication tracker to help you stay on track with your treatment plan.

To apply Glyceryl Trinitrate Cream, clean and dry the affected area, then use the applicator or your fingertip to apply a thin layer of cream, gently massaging it into the skin as directed by your healthcare provider or the product instructions.

Following are the conditions/situations when Glyceryl Trinitrate Cream should not be used:

• Must not be used if you are allergic to glyceryl trinitrate or any other nitrates, or similar medicines.
• Not suitable for individuals with severe anemia or very low blood pressure.
• Contraindicated in patients with head injuries, increased intracranial pressure, or a recent stroke.
• Should not be used if you have a heart condition called hypertrophic obstructive cardiomyopathy.
• Avoid using if you have a condition where the heart muscle becomes inflamed (pericarditis).
• Not recommended for individuals with severe aortic stenosis (narrowing of the aortic valve in the heart).
• Do not use if you have a collapsed lung (pneumothorax) or at risk of this condition.
• Contraindicated in patients with closed-angle glaucoma.
• Should not be used in individuals with a blood disorder called glucose-6-phosphate dehydrogenase (G6PD) deficiency.

The side effects of Glyceryl Trinitrate Cream may include:

• Headache
• Dizziness
• Lightheadedness
• Flushing
• Skin irritation at the application site
• Low blood pressure (hypotension)
• Rapid or pounding heartbeat (palpitations)
• Nausea and vomiting.

Following are the precautions and warnings for Glyceryl Trinitrate Cream:

• Avoid using this cream if you have a known allergy to glyceryl trinitrate or any other components of the cream.
• Do not apply to broken or irritated skin. Ensure the treatment area is clean and dry before application.
• Exercise caution if you have a history of low blood pressure or if you are taking medications for hypertension, as this cream may cause a further drop in blood pressure.
• Avoid using tight bandages or dressings over the application site as it may increase the absorption of the medication.
• This cream is for external use only and should not be ingested or applied to mucous membranes.
• Keep out of reach of children and pets. Store at room temperature, away from direct sunlight and heat.
• Consult a healthcare professional if you are pregnant, planning to become pregnant, or breastfeeding before using this medication.

Following are the drug interactions for Glyceryl Trinitrate Cream:

• Sildenafil and other phosphodiesterase inhibitors may potentiate the hypotensive effect, leading to excessive blood pressure drop.
• Alcohol can cause increased vasodilation and potentially exacerbate the hypotensive effects of glyceryl trinitrate.
• Beta-blockers, when used concomitantly, may reduce the anti-anginal effectiveness of glyceryl trinitrate.
• Calcium channel blockers, such as verapamil or diltiazem, can enhance the vasodilatory and hypotensive effects of glyceryl trinitrate.
• ACE inhibitors can cause an additive hypotensive effect when used with glyceryl trinitrate.
• Diuretics, especially when dehydration occurs, may increase the risk of hypotension with glyceryl trinitrate.
• Ergot alkaloids may counteract the vasodilatory effects of glyceryl trinitrate, potentially leading to increased blood pressure.

Following are the food interactions for Glyceryl Trinitrate Cream:

• Avoid consuming alcohol during the treatment period, as it can cause excessive dizziness and lightheadedness, especially when combined with the cream's vasodilatory effects.
• Grapefruit and grapefruit juice should be consumed with caution. These can affect the blood levels of the medication, potentially increasing the risk of side effects.
• Caffeine intake should be monitored. Caffeine may interact with the cream, leading to increased heart rate and blood pressure fluctuations.
• Avoid foods rich in nitrates and nitrites, such as processed meats, as they can enhance the vasodilatory effects of the cream and potentially lead to hypotension.
• High-fat meals might delay the absorption of the active ingredient, affecting the overall effectiveness of the cream.
• Spicy foods may cause skin irritation or sensitivity, especially when applied topically, and could potentially increase the risk of skin reactions.
• Avoid excessive salt intake, as it may counteract the effects of the cream by promoting fluid retention and potentially raising blood pressure.
• Consult your healthcare provider for specific dietary guidelines, as individual responses to the cream may vary.

Glyceryl Trinitrate Cream should be stored in a cool and dry place, preferably at room temperature, away from direct sunlight, heat, and moisture. It is crucial to keep the cream in its original container, tightly sealed, to maintain its integrity and prevent contamination. Do not expose the cream to extreme temperatures or store it in hot areas like the bathroom or near the kitchen stove. Always check the expiration date, and if the cream has passed its expiry, do not use it and dispose of it carefully. For proper disposal, consult your pharmacist or local waste management guidelines to ensure it is done safely and responsibly, without causing harm to the environment. Keep the cream out of children's reach to prevent accidental contact or ingestion.

Following are the quick tips for Glyceryl Trinitrate Cream:

• Wash your hands before and after applying the cream to maintain hygiene.
• Clean and dry the affected area before applying the cream for better absorption.
• Apply a thin layer of cream to the skin, gently massaging it until it is absorbed.
• Avoid applying the cream on broken or irritated skin to prevent discomfort.
• Do not cover the treated area with tight clothing or bandages to allow ventilation.
• Store the cream at room temperature, away from direct sunlight and moisture.
• Consult your doctor if symptoms persist or worsen during treatment.