Gyno-Travogen (1%) 40g Vaginal Cream

Isoconazole cream, a topical antifungal medication, exerts its therapeutic effect by targeting the cell membrane of susceptible fungi. Its primary mechanism of action involves binding to a specific enzyme called lanosterol 14-alpha-demethylase, which plays a crucial role in the biosynthesis of ergosterol, a vital component of fungal cell membranes. By inhibiting this enzyme, isoconazole disrupts the normal production of ergosterol, leading to defects in the fungal cell membrane structure and function. This disruption compromises the integrity of the fungal cells, ultimately inhibiting their growth and proliferation. This selective action against fungal organisms makes isoconazole an effective treatment for various dermatophytic infections and certain yeast infections of the skin.

Isoconazole

Imidazole antifungal.

Cream

The following are the uses of Isoconazole Cream:

• Used for treating fungal infections, particularly those affecting the skin and mucous membranes.
• Used for relieving symptoms like itching, redness, and discomfort caused by fungal growth.
• Used for treating conditions such as athlete's foot, jock itch, ringworm, and yeast infections.
• Used for managing skin irritation and inflammation associated with fungal infections.
• Used for restoring the skin's natural barrier function and promoting healing.
• Used for preventing the spread of fungal infections to other body parts.
• Used for providing targeted treatment to affected areas, ensuring effective relief.
• Used for maintaining skin health and preventing recurrence of fungal infections.

Follow these dosage instructions:

• Skin fungal infections

To be applied as a 1% or 2% cream on affected areas.

• Vaginal Infections

As a pessary

In the case of an overdose of Isoconazole Cream, it is important to remain calm and take immediate action. First, thoroughly wash the affected area with water to remove any excess cream. Avoid applying excessive water pressure, and gently pat the area dry. Seek medical advice promptly, even if no symptoms are present, as healthcare professionals can provide specific guidance based on individual circumstances.

In the case of a missed dose of Isoconazole Cream, it is important to apply the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed application and continue with your regular dosing schedule. Do not apply extra cream to make up for the missed dose, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for advice on how to adjust your treatment plan accordingly. It's crucial to maintain a consistent application schedule for the best treatment outcome.

To use Isoconazole Cream, clean and dry the affected area, then apply a thin layer of the cream to the skin, gently rubbing it in, usually twice a day or as directed by your doctor.

Following are the conditions/situations when Isoconazole Cream should not be used:

• Do not use if you are allergic to any of the ingredients in the cream.
• Avoid using the cream if you have a known sensitivity or allergy to azole antifungals.
• Not suitable for individuals with a history of hypersensitivity reactions to Isoconazole.
• Do not apply the cream to the eyes, mouth, or open wounds.
• Avoid using the cream on areas of skin that are severely irritated or broken.
• Do not use the cream if you are pregnant or breastfeeding without medical advice.
• Not recommended for children without a doctor's prescription.
• Do not use the cream to treat conditions other than fungal skin infections.
• Avoid using the cream on large areas of the body without medical supervision.
• Discontinue use and seek medical attention if you experience severe irritation or an allergic reaction.

The side effects of Isoconazole Cream may include:

• Skin irritation or redness at the application site
• Burning or stinging sensation
• Itching or rash
• Dryness or peeling of the skin
• Swelling or inflammation
• Allergic reactions (hives, difficulty breathing, swelling of the face/lips/tongue)
• Increased skin sensitivity to sunlight

Following are the precautions and warnings for Isoconazole Cream:

• Avoid applying the cream to eyes, mouth, or open wounds. It is meant for external use only.
• Wash your hands thoroughly before and after applying the cream to prevent accidental contact with sensitive areas.
• If you are pregnant or breastfeeding, consult your doctor before using this medication. The potential effects on fetal development and nursing infants should be discussed.
• Discontinue use and seek medical attention if you experience severe irritation, burning, or allergic reactions at the application site.
• Do not cover the treated area with airtight dressings or bandages, as this may increase the risk of local adverse reactions.
• Isoconazole cream is for external use only and should not be ingested. Keep it out of reach of children.
• Do not use this medication if you are allergic to isoconazole or any of its ingredients. Always check the ingredients list for potential allergens.
• Consult your healthcare provider if your symptoms persist or worsen despite using the cream as directed. They may need to adjust the treatment plan.

Following are the drug interactions for Isoconazole Cream:

• No clinically significant interactions have been reported with other topical medications, but concurrent use with other antifungals may increase the risk of skin irritation.
• Isoconazole may interact with oral antifungal medications, such as fluconazole, potentially increasing systemic exposure and side effects.
• Avoid using other vaginal creams or suppositories during treatment with Isoconazole Cream, as they may dilute or alter the effectiveness of the medication.
• The cream may reduce the effectiveness of latex-based contraceptives, including condoms and diaphragms.
• Systemic absorption of isoconazole can occur, and it may interact with oral medications metabolized by the liver, such as certain anticoagulants and antiepileptic drugs.
• Topical corticosteroids, if used concurrently, may mask the symptoms of a fungal infection, allowing it to progress unchecked.
• Isoconazole may increase the risk of certain oral medications' side effects, including statins and calcium channel blockers, by inhibiting liver enzymes.

Following are the food interactions to consider with Isoconazole Cream:

• Avoid consuming large amounts of caffeine while using Isoconazole, as it may increase the risk of side effects such as nervousness and tremors.
• Grapefruit and grapefruit juice should be consumed with caution as they can potentially interact with Isoconazole, affecting its metabolism in the body.
• Avoid alcohol-containing foods and beverages as they may increase skin irritation and dryness when used with Isoconazole Cream.
• Foods rich in sugar and simple carbohydrates may increase the growth of yeast and should be consumed in moderation during treatment.
• Avoid oily and greasy foods, as they can potentially affect the absorption of the medication and lead to reduced effectiveness.
• There is no known interaction with dairy products, but maintaining a balanced diet is advisable.
• Always follow dietary recommendations provided by your healthcare professional, especially if you have specific dietary restrictions or medical conditions.
• Generally, Isoconazole Cream is not significantly affected by food, but individual experiences may vary.

Isoconazole Cream should be stored in a cool and dry place, preferably at room temperature, ensuring it is protected from direct sunlight and moisture. Keep the cream in its original container with the lid tightly secured to maintain its integrity and prevent contamination. Avoid storing it in areas with temperature fluctuations like bathrooms, near stoves, or radiators, as these conditions can impact the cream's effectiveness. Dispose of any unused or expired cream responsibly; do not flush it or pour it down the drain. Consult your pharmacist or healthcare provider for appropriate disposal methods. Keep the cream out of children's reach to prevent accidental contact or ingestion.

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Following are the quick tips for Isoconazole Cream:

• Wash your hands before applying the cream to maintain hygiene.
• Clean and dry the affected area before applying the cream.
• Apply a thin layer of cream to the affected skin and gently rub it in.
• Avoid covering the treated area with tight-fitting clothing to allow the cream to work effectively.
• Do not apply the cream near your eyes, mouth, or open wounds.
• If you are using other topical medications, apply them at different times to avoid interactions.
• Store the cream at room temperature, away from direct sunlight and moisture.