GYNOGEN HP 75MG IU

Menotrophin injection, often referred to as human menopausal gonadotropin (hMG), is a combination of two hormones,follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity. Its mechanism of action primarily involves stimulating the development of ovarian follicles and promoting ovulation. FSH in the injection stimulates the growth and maturation of ovarian follicles, leading to the production of multiple follicles. This stimulation encourages the follicles to produce estrogen and progress towards ovulation. Meanwhile, the LH component in menotrophin triggers ovulation by inducing the final maturation of the dominant follicle and the subsequent release of the egg (ovulation). The combined effect of FSH and LH activities in menotrophin injection is to mimic the natural hormonal changes that occur during the menstrual cycle, thereby supporting the process of ovulation and enhancing fertility.

Gonadotropin

Injection

The following are the uses of Menotrophin Injection:

• Used for stimulating the development of multiple follicles in the ovaries, aiding fertility treatments.
• Used for ovulation induction, assisting women with ovulation disorders to release an egg.
• Used for treating infertility in women by regulating and triggering ovulation.
• Used for enhancing in-vitro fertilization (IVF) procedures, improving egg production.
• Used for superovulation, a process to increase the chances of successful fertilization.
• Used for controlled ovarian hyperstimulation to retrieve multiple eggs for IVF.
• Used for improving pregnancy rates in assisted reproductive techniques.

In the case of an overdose of Menotrophin Injection, immediate medical intervention is necessary. Symptoms may include severe abdominal pain, enlarged ovaries, and hyperstimulation of the ovaries. Seek emergency care if you experience these symptoms, as they can lead to life-threatening complications. Medical professionals should closely monitor vital signs and provide supportive care to manage the overdose's effects. Prompt action is vital to prevent potential long-term health consequences.

In the case of a missed dose of Menotrophin Injection, it is important to consult your healthcare provider as soon as possible. They will guide you on how to adjust the dosage or reschedule your injection. Do not attempt to double the dose or administer it too close to the next scheduled injection. If you miss a dose, contact your doctor immediately for advice on the best course of action to ensure the effectiveness of the treatment. They may provide specific instructions based on your individual circumstances.

To administer the Menotrophin Injection, ensure the injection site is clean, insert the needle at a 90-degree angle, and slowly inject the prescribed dose subcutaneously or intramuscularly, as directed by your healthcare provider, then gently withdraw the needle and apply light pressure with a sterile cotton ball if needed.

Following are the conditions or circumstances when Menotrophin Injection should not be administered:

• Allergic reaction Not suitable for individuals with a known or suspected allergy to Menotrophin or any of its components.
• Pregnancy Contraindicated in pregnant women as it can interfere with natural hormone production.
• Ovarian Hyperstimulation Syndrome (OHSS) Should not be used if there is a history or risk of OHSS.
• Ovarian or Uterine Abnormalities Not recommended for women with ovarian cysts (except PCOS), ovarian enlargement, or uterine fibroids.
• Endometriosis Menotrophin is not advised for women with severe endometriosis.
• Undiagnosed Vaginal Bleeding Should not be used if there is unexplained vaginal bleeding.
• Pituitary or Hypothalamic Disorders Contraindicated in patients with pituitary or hypothalamic disorders that are not controlled.
• Adrenal Insufficiency Not suitable for individuals with adrenal gland disorders or adrenal insufficiency.
• Thyroid Disorders Should not be used if thyroid function is not adequately controlled.
• Liver Disease Contraindicated in patients with liver disease or abnormal liver function.
• History of Thromboembolism Not recommended for women with a history of blood clots or thromboembolic disorders.
• Cancer Menotrophin should not be used in individuals with known or suspected hormone-dependent cancers.

The side effects of Menotrophin Injection may include:

• Abdominal pain or pelvic discomfort
• Allergic reactions (such as rash, itching, swelling, or difficulty breathing)
• Ovarian hyperstimulation syndrome (OHSS) • symptoms include severe abdominal pain, rapid weight gain, nausea, vomiting, and diarrhea.
• Headaches
• Mood changes, including depression or irritability
• Mild ovarian enlargement or cyst formation
• Mild bloating or fluid retention
• Injection site reactions (such as redness, swelling, or pain)

Following are the precautions and warnings for Menotrophin Injection:

• This medication should be used under strict medical supervision due to its potential for causing Ovarian Hyperstimulation Syndrome (OHSS), a serious medical condition.
• Not recommended for individuals with known allergies to menotrophins or any of its components.
• Patients with a history of ovarian cysts, liver disease, or adrenal gland issues should use with caution and under medical supervision.
• If you experience abdominal pain, swelling, nausea, or vomiting after the injection, seek immediate medical attention as these may be signs of OHSS.
• Avoid if you have primary ovarian failure, as it is unlikely to be effective in this condition.
• Exercise caution if you have thyroid or pituitary gland disorders, as it may affect hormone levels.
• This medication is not intended for use in children, and special care should be taken when administering to elderly patients.
• Women who are pregnant or breastfeeding should consult their doctor before using this medication.

Following are the drug interactions for Menotrophin Injection:

• When used with other gonadotropins, the effects can be additive, potentially leading to ovarian hyperstimulation syndrome.
• Menotrophin may interact with clomiphene, affecting ovulation and requiring careful monitoring.
• Concomitant use with GnRH agonists/antagonists can impact ovulation timing and response.
• The risk of multiple pregnancies is increased when combined with assisted reproductive technologies.
• Corticosteroids can influence the efficacy of menotrophin, and adjustments may be necessary.
• Insulin requirements may change due to menotrophin's effect on glucose metabolism.
• Certain herbal supplements (e.g., blue cohosh, black cohosh) should be used cautiously as they may impact hormone balance.

Following are the food interactions for Menotrophin Injection:

• Alcohol consumption should be avoided as it may interfere with hormone regulation and impact the effectiveness of the treatment.
• Caffeine intake should be monitored as it can affect blood flow to the reproductive organs and potentially impact fertility treatments.
• Avoid grapefruit and grapefruit juice as they may alter hormone metabolism, affecting treatment outcomes.
• High-fat meals might influence the absorption of medications, so it's advisable to consult healthcare professionals for specific instructions.
• Stay hydrated by drinking adequate water, ensuring optimal blood flow and supporting the treatment process.
• Maintain a balanced diet rich in nutrients, supporting overall health and potentially enhancing the effectiveness of the injection.
• Consult your doctor for personalized dietary recommendations during Menotrophin treatment.

Menotrophin Injection should be stored in a refrigerator at a temperature between 2°C to 8°C (36°F to 46°F). It is crucial to keep the injection in its original packaging to protect it from light and moisture. Do not freeze the medication as it may affect its potency. Always check the expiration date before use and discard any expired or unused vials. Proper disposal is essential

do not dispose of in regular trash or flush down the toilet. Contact your healthcare provider or pharmacist for guidance on safe disposal methods to protect the environment. Keep the medication out of reach of children and pets to prevent accidental exposure or ingestion.

Following are the quick tips for Menotrophin Injection:

• Consult a doctor for the correct dosage and usage instructions for your specific condition.
• Administer the injection under medical supervision; do not self-inject.
• Ensure the injection is given at the right time and frequency as prescribed.
• Gently roll the vial/ampoule between your palms before use to mix the contents well.
• Use a new needle and syringe for each injection to maintain sterility.
• Dispose of used needles and syringes safely in a puncture-proof container.
• Store the medication as directed, typically in a refrigerator, and protect it from light.
• Inform your doctor if you experience any side effects or allergic reactions.