HAES STERIL 500ML DRIP

Hydroxyethyl starch (HES) 500ml infusion works by increasing the volume of fluid in the blood vessels. Its mechanism of action involves the ability of HES molecules to bind to and retain water in the intravascular space. When administered intravenously, HES molecules expand the plasma volume, thereby improving blood flow and oxygen delivery to tissues. The hydroxyethyl groups on the starch molecules interact with water molecules, preventing their rapid leakage out of the blood vessels. This helps to maintain blood volume and stabilize blood pressure. HES 500ml infusion is designed to provide temporary fluid replacement and is metabolized and eliminated from the body over time.

Hydroxy Ethyl Starch 500ml

Volume expander

Infusion

The following are the uses of Hydroxy Ethyl Starch 500ml Infusion:

• Used for volume expansion and restoration of blood volume in patients with severe hypovolemia, especially after trauma, surgery, or burns.
• Used for maintaining blood pressure and ensuring adequate organ perfusion during critical care.
• Used for treating acute blood loss anemia when blood transfusions are not readily available or suitable.
• Used for improving cardiac output and oxygen delivery to tissues in patients with circulatory instability.
• Used for priming heart-lung machines during cardiopulmonary bypass surgeries.
• Used for fluid resuscitation in patients with septic shock to optimize hemodynamics.
• Used for preventing excessive bleeding during surgical procedures by improving clotting mechanisms.

In the case of an overdose of Hydroxy Ethyl Starch 500ml Infusion, it is crucial to act promptly. Overdosing may lead to severe health complications, including kidney damage, blood clotting issues, and allergic reactions. Symptoms can range from mild skin irritation to more serious respiratory distress. If an overdose is suspected, immediate medical intervention is necessary. Healthcare professionals should be contacted for guidance and to determine the appropriate treatment plan.

In the case of a missed dose of Hydroxy Ethyl Starch 500ml Infusion, it is essential to administer the missed dose as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare professional for guidance on how to adjust the dosing schedule to ensure the treatment remains effective.

To administer the Hydroxy Ethyl Starch 500ml Infusion, prepare the intravenous line, ensure proper insertion of the IV cannula, and slowly infuse the prescribed amount of the solution over the specified duration as directed by your healthcare professional.

Here are the conditions or situations when Hydroxyethyl Starch 500ml Infusion should not be used:

• Not suitable for patients with a known allergy or hypersensitivity to hydroxyethyl starch or any of its components.
• Contraindicated in patients with severe kidney disease or those on dialysis.
• Should not be used in patients with severe liver disease or impaired liver function.
• Not recommended for patients with a history of bleeding disorders or those on blood-thinning medications.
• Should be avoided in patients with severe heart failure or cardiovascular disease.
• Contraindicated during pregnancy or breastfeeding.
• Not suitable for patients with a history of anaphylactic reactions to any substance.
• Should not be used in patients with uncontrolled hypertension (high blood pressure).
• Avoid in patients with severe fluid retention or edema.

The side effects of Hydroxy Ethyl Starch 500ml Infusion may include:

• Allergic reactions, such as itching, rash, or hives.
• Swelling of the face, lips, or tongue.
• Difficulty breathing or swallowing.
• Nausea and vomiting.
• Increased heart rate or irregular heartbeat.
• Hypersensitivity reactions, including anaphylaxis.
• Hypokalemia (low potassium levels in the blood).
• Renal impairment or acute kidney injury.

Following are the precautions and warnings for Hydroxy Ethyl Starch 500ml Infusion:

• Avoid use in patients with known hypersensitivity to hydroxyethyl starch or any of its components.
• Monitor fluid balance and electrolyte levels closely, especially in patients with renal impairment or heart conditions.
• Use with caution in patients with bleeding disorders or those on anticoagulant therapy, as it may affect blood clotting.
• Not recommended for patients with severe liver disease or those at risk of fluid overload.
• Do not use if the solution is cloudy or contains particles, and ensure the infusion set is correctly assembled.
• Elderly patients may require closer monitoring due to potential age-related renal function decline.
• Pregnant and breastfeeding women should only use this medication if clearly needed and under medical supervision.
• Always administer under the guidance of a healthcare professional and follow the prescribed dosage and infusion rate.

Following are the drug interactions for Hydroxy Ethyl Starch 500ml Infusion:

• Concurrent use with nephrotoxic drugs (e.g., aminoglycosides, cisplatin) may increase the risk of kidney injury.
• Avoid use with other volume expanders or hypertonic solutions, as it may lead to fluid overload and electrolyte imbalances.
• Hydroxyethyl starch may interfere with the efficacy of anticoagulants, such as heparin, potentially affecting blood clotting.
• Use with caution in patients receiving diuretics, as it may reduce their effectiveness and impact fluid balance.
• Interaction with certain medications metabolized by the liver could potentially alter the effects of those drugs.
• In combination with medications affecting blood pressure, careful monitoring is required to prevent hypotension.
• Patients taking medications that impact platelet function should be monitored for bleeding risks.

Following are the food interactions for Hydroxy Ethyl Starch 500ml Infusion:

• Hydroxyethyl starch solutions are not meant for oral consumption; hence, direct food interactions are not applicable.
• This medication is administered intravenously and should not be mixed with any food or drink.
• Avoid alcohol consumption during treatment, as it may impact the body's fluid balance and liver function, affecting the medication's effectiveness.
• Grapefruit and grapefruit juice should be avoided as they may interfere with the body's fluid regulation, potentially affecting the medication's action.
• Caffeinated beverages should be limited as they can impact hydration levels and interact with the medication's fluid-balancing properties.
• Always inform your healthcare provider about your diet and fluid intake to ensure the medication's safe and effective use.
• Maintain a balanced diet to support overall health during treatment.
• Consult your doctor or pharmacist for specific dietary recommendations based on your medical condition and treatment plan.

Hydroxy Ethyl Starch 500ml Infusion should be stored in a controlled environment, preferably in a cool and dry place, maintaining a temperature between 20-25°C (68-77°F). Protect the infusion from direct sunlight, extreme temperatures, and moisture to ensure its integrity. Store it in its original packaging, tightly sealed, to prevent contamination and maintain sterility. When disposing of the infusion, do not pour it down the drain or flush it in the toilet. Instead, follow local guidelines for medical waste disposal or consult healthcare professionals for appropriate methods to ensure safe and environmentally friendly disposal. Keep this medication out of children's reach to prevent accidental ingestion, and always handle it with care.

Following are the quick tips for Hydroxy Ethyl Starch 500ml Infusion:

• Administer the infusion under medical supervision for safety.
• Ensure proper IV access and monitor for any signs of fluid overload.
• Infuse at a controlled rate as directed by the prescription.
• Regularly assess fluid balance and vital signs during and after the infusion.
• Report any adverse reactions such as allergic responses or swelling immediately.
• Store the infusion as directed, typically at room temperature and away from direct sunlight.
• Do not use if the solution is discolored or contains particles.