HAGLOX CR 12.5MG TAB

Paroxetine's primary mechanism of action is as a potent and selective serotonin reuptake inhibitor (SSRI). It works by blocking the reabsorption of serotonin in the brain, leading to increased levels of serotonin in the synaptic cleft. Specifically, paroxetine binds to the presynaptic transporter proteins responsible for the reuptake of serotonin, preventing serotonin molecules from being transported back into the presynaptic neuron. This inhibition enhances serotonergic neurotransmission by allowing more serotonin to remain available in the synaptic cleft, where it can bind to postsynaptic receptors. By modulating serotonin levels, paroxetine helps to regulate mood, emotions, and anxiety, making it effective in the treatment of various psychiatric disorders, primarily depression, anxiety disorders, and obsessive-compulsive disorder.

Selective Serotonin Reuptake Inhibitor (SSRI)

Tablet

The following are the uses of Paroxetine 5mg Tablet:

• Used for treating depression and major depressive disorder.
• Used to alleviate symptoms of anxiety and obsessive-compulsive disorder (OCD).
• Effective in managing panic disorder and reducing panic attacks.
• Helps control excessive worry and physical symptoms of anxiety.
• Used to treat post-traumatic stress disorder (PTSD) symptoms.
• Can be utilized for managing premenstrual dysphoric disorder (PMDD).
• Assists in improving mood and overall emotional well-being.

In the case of an overdose of Paroxetine 5mg Tablets, individuals may experience symptoms such as dizziness, drowsiness, nausea, vomiting, and in severe cases, seizures or an irregular heartbeat. Prompt medical attention is necessary, as the doctor may recommend specific treatment options, including inducing vomiting or administering activated charcoal to prevent further absorption of the medication. It is important to act quickly and seek medical assistance to ensure the best possible outcome.

In the case of a missed dose of Paroxetine 5mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to get back on track with your medication regimen. It is advisable to set reminders or alarms to help you remember to take your medication at the correct times each day.

To take Paroxetine 5mg Tablets, swallow the tablet whole with a full glass of water, preferably in the morning or as directed by your healthcare professional, and do not crush, chew, or break the tablet.

Following are the conditions when Paroxetine 5mg Tablet should not be used:

• Should not be used in individuals with a known allergy to Paroxetine or any selective serotonin reuptake inhibitors (SSRIs).
• Not suitable for patients with narrow-angle glaucoma.
• Contraindicated in individuals who are taking Monoamine Oxidase Inhibitors (MAOIs) or have taken them in the last 14 days.
• Avoid if you have a bleeding disorder or if you are taking blood thinners.
• Should not be used in patients with severe kidney or liver disease.
• Not recommended for individuals with a history of seizures or epilepsy.
• Avoid if you have a history of manic episodes or bipolar disorder.
• Do not use in children and adolescents under 18 years of age.
• Contraindicated in individuals with uncontrolled high blood pressure.

The side effects of Paroxetine 5mg Tablet may include:

• Nausea and vomiting
• Diarrhea or constipation
• Dry mouth
• Dizziness or lightheadedness
• Increased sweating
• Insomnia or drowsiness
• Sexual dysfunction, including decreased libido and difficulty reaching orgasm
• Weight changes, either gain or loss

Following are the precautions and warnings for Paroxetine 5mg Tablet:

• Not suitable for individuals with a known hypersensitivity or allergy to Paroxetine or any other similar antidepressants.
• May cause dizziness or sleepiness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Caution is advised for patients with a history of liver or kidney disease, as Paroxetine may require dosage adjustments in these cases.
• Should be used with caution in individuals with a history of seizures, as it may lower the seizure threshold.
• Elderly patients may be more sensitive to the side effects, and regular monitoring is necessary.
• Not recommended for children and adolescents under 18 years of age.
• If you have a history of eye problems, such as glaucoma, consult your doctor before taking Paroxetine as it may affect eye pressure.

Following are the drug interactions for Paroxetine 5mg Tablet:

• Paroxetine may enhance the effects of other antidepressants like SSRIs, tricyclic antidepressants, or MAOIs, increasing the risk of serotonin syndrome.
• It can interact with anticoagulants such as warfarin, possibly altering its effects and requiring close monitoring of coagulation parameters.
• Alcohol and benzodiazepines should be used cautiously with Paroxetine, as they may cause excessive sedation and impaired cognitive function.
• The risk of bleeding may increase when Paroxetine is combined with NSAIDs like ibuprofen or aspirin.
• Paroxetine can affect the metabolism of certain medications, including some anticonvulsants and antipsychotics, leading to elevated blood levels and potential side effects.
• Drugs that influence liver enzymes may alter the metabolism of Paroxetine, requiring dosage adjustments.
• Caution is advised when using Paroxetine with other medications that have a narrow therapeutic index, as it may affect their clearance and increase side effects.

Following are the food interactions for Paroxetine 5mg Tablet:

• Avoid consuming alcohol while taking this medication as it can increase the risk of side effects and may cause excessive drowsiness and sedation.
• Grapefruit and grapefruit juice should be consumed with caution as they may increase the blood levels of Paroxetine, potentially leading to an increased risk of side effects.
• Avoid eating high-fat meals as they can decrease the absorption of Paroxetine, which may reduce its effectiveness.
• Caffeine-rich foods and beverages should be limited as they can interact with Paroxetine, potentially causing increased anxiety or insomnia.
• Consuming foods high in tyramine (aged cheeses, cured meats, fermented foods) should be avoided as they may interact with Paroxetine, leading to a dangerous spike in blood pressure.
• Be cautious with salt intake, as Paroxetine may increase sodium levels in the body, especially in individuals with pre-existing conditions.
• Always ensure you drink enough water to avoid dehydration, as Paroxetine may cause dry mouth and increased thirst.
• There are no specific food restrictions, but maintaining a balanced diet is essential for overall well-being during Paroxetine therapy.

Paroxetine 5mg Tablets should be stored in a cool and dry place, preferably at room temperature, away from direct exposure to sunlight, heat, and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. It is crucial not to store them in the bathroom or near any heat-emitting appliances. Always check the expiration date on the packaging, and dispose of any unused or expired tablets promptly. When disposing of the medication, do not flush it or pour it down the drain; instead, follow local guidelines or consult a pharmacist for proper disposal methods to ensure environmental safety. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Paroxetine 5mg Tablet:

• Start with a low dose and gradually increase as directed by your doctor.
• Take the tablet at the same time each day to maintain consistent levels.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Avoid alcohol consumption while taking this medication.
• Inform your doctor if you have any pre-existing medical conditions or are taking other medications.
• Do not stop taking the medication without consulting your doctor to prevent withdrawal symptoms.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.