Hepa-Merz (5g) 10ml, 1s Ampoule Infusions

L-Ornithine L-Aspartate (LOLA) infusion works by supplying the body with two key amino acids, L-ornithine and L-aspartic acid. L-ornithine plays a crucial role in the urea cycle, where it helps to remove excess ammonia from the body by converting it into urea. This process is particularly important in individuals with impaired liver function, as it helps to reduce ammonia levels, which can be toxic. L-aspartic acid, on the other hand, acts as a precursor for the synthesis of other amino acids and participates in energy metabolism, particularly in the citric acid cycle. By providing these amino acids, L-Ornithine L-Aspartate infusion supports the body's natural processes for ammonia detoxification and energy production, aiding in the management of conditions associated with hyperammonemia and metabolic imbalances.

L-Ornithine, L-Aspartate

Amino acid derivative.

Infusion

The following are the uses of L-Ornithine, L-Aspartate Infusion:

• Used for treating hepatic coma and other complications of liver failure.
• Used to improve liver function in patients with cirrhosis or acute liver injury.
• Used to reduce ammonia levels in the blood, which can accumulate due to liver dysfunction.
• Used to enhance the body's ability to eliminate toxins, especially in cases of liver impairment.
• Used to support protein metabolism and promote a positive nitrogen balance in liver disease patients.
• Used as an adjunct therapy to improve survival rates and reduce hospitalization time in acute liver failure.
• Used to manage symptoms of hepatic encephalopathy, such as confusion and altered mental status.
• Used to aid in the recovery process after liver transplantation or severe liver trauma.

In the case of an overdose of L-Ornithine, L-Aspartate Infusion, symptoms may include gastrointestinal disturbances, increased blood ammonia levels, and neurological effects. Prompt medical attention is required, as treatment involves managing these symptoms and providing supportive care. The severity of the overdose can vary, so quick action and assessment by healthcare professionals are essential to ensure appropriate treatment and minimize potential long-term effects.

In the case of a missed dose of L-Ornithine, L-Aspartate Infusion, it is essential to administer the missed dose as soon as possible. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. If you have any concerns or questions, it is best to consult your healthcare provider for specific instructions regarding missed doses.

To administer the L-Ornithine, L-Aspartate Infusion, ensure the solution is at room temperature, clean the injection site with an antiseptic, insert the needle at a 90-degree angle, and slowly inject the prescribed amount as directed by your healthcare professional, typically over a period of 30-60 minutes.

Here are the situations when L-Ornithine, L-Aspartate Infusion should not be used:

• Not recommended for individuals with a known allergy or hypersensitivity to L-ornithine, L-aspartate, or any of its excipients.
• Contraindicated in patients with severe liver disease or liver failure, as it may worsen their condition.
• Should not be used in individuals with severe kidney disease or those on dialysis, as it can increase the risk of ammonia toxicity.
• Not suitable for people with Wilson's disease, a rare genetic disorder affecting copper metabolism.
• Avoid in patients with a history of seizures or epilepsy, as it may lower the seizure threshold.
• Not recommended for individuals with a history of mania or bipolar disorder, as it may exacerbate symptoms.
• Contraindicated in patients with severe heart or circulatory problems, including heart failure.
• Should not be used in individuals with a history of hereditary blood disorders like porphyria.

The side effects of L-Ornithine, L-Aspartate Infusion may include:

• Nausea and vomiting
• Stomach pain or cramps
• Diarrhea
• Dizziness or lightheadedness
• Fatigue or weakness
• Skin rash or itching
• Increased thirst and urination
• Changes in blood pressure

Following are the precautions and warnings for L-Ornithine, L-Aspartate Infusion:

• Not suitable for patients with severe liver disease, as it may lead to increased ammonia levels and potential liver damage.
• Patients with kidney impairment should use with caution and under medical supervision, as it may affect kidney function.
• Avoid if allergic to any of the infusion's components to prevent adverse reactions.
• Not recommended for use in children due to insufficient data on safety and efficacy.
• Elderly patients may require closer monitoring as they are more prone to adverse effects.
• Should be used with caution in patients with diabetes, as it may affect blood sugar levels.
• May cause metabolic acidosis, especially in patients with pre-existing metabolic disorders, and should be monitored closely.

Following are the drug interactions for L-Ornithine, L-Aspartate Infusion:

• Concurrent use with ammonium salts can lead to increased risk of ammonia toxicity, potentially affecting the central nervous system.
• It may interact with anti-seizure medications like valproic acid, potentially affecting the metabolism and effectiveness of these drugs.
• L-Ornithine, L-Aspartate can affect the elimination of certain medications, such as penicillins and cephalosporins, leading to increased levels of these drugs.
• Use with other amino acid supplements or medications containing amino acids may result in imbalances and potential adverse effects.
• Caution is advised when combining with medications that affect kidney function, as it may alter the elimination of these drugs.
• This medication may influence the effectiveness of immunosuppressants, potentially requiring dosage adjustments.
• L-Ornithine, L-Aspartate can impact the absorption of certain medications, particularly those requiring an acidic environment in the stomach for absorption.

Following are the food interactions for L-Ornithine, L-Aspartate Infusion:

• Avoid consuming large amounts of protein-rich foods during treatment, as this may reduce the efficacy of the infusion.
• High-protein diets should be managed carefully to ensure the medication's effectiveness.
• Limit or avoid the consumption of arginine-rich foods like nuts, seeds, soy, and whole grains, as arginine can compete with ornithine for absorption.
• Alcohol should be avoided as it may impact liver function and interact negatively, especially in individuals with liver-related conditions.
• Avoid caffeine-rich beverages like coffee and energy drinks, as they may interfere with the relaxing effects of the medication.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect liver enzymes and potentially impact the metabolism of the medication.
• Maintain a balanced diet with a variety of nutrients to support overall health during treatment.
• Stay hydrated by drinking adequate water to aid in the infusion's effectiveness and overall well-being.

L-Ornithine, L-Aspartate Infusion should be stored in a controlled environment, preferably at room temperature between 20-25°C (68-77°F), away from excessive heat, direct sunlight, and moisture. Ensure the infusion solution is protected from freezing, as it may affect the integrity of the medication. Store it in its original packaging, tightly sealed, to maintain sterility and prevent contamination. When disposing of unused or expired infusions, do not pour them down the drain or flush them; instead, follow local guidelines for medical waste disposal or consult a healthcare professional for advice on proper disposal methods. Keep this medication out of the sight and reach of children to prevent accidental exposure.

Following are the quick tips for L-Ornithine, L-Aspartate Infusion:

• Administer the infusion under medical supervision for safety and proper administration.
• Ensure the infusion is at room temperature before use.
• Use a sterile, non-pyrogenic infusion set for administration.
• Follow the prescribed dosage and infusion rate as directed by your healthcare provider.
• Avoid rapid infusion to prevent adverse effects.
• Monitor vital signs during and after the infusion.
• Report any signs of allergic reactions or side effects immediately.
• Store the infusion as directed on the packaging.