HEPAGEL 120ML SYP

Ornithine Aspartate Syrup/Suspension works primarily by enhancing the urea cycle, a key process in the body's nitrogen metabolism. The active ingredients, ornithine and aspartate, play crucial roles in this mechanism. Ornithine stimulates the production of arginine and subsequently nitric oxide, which helps improve blood flow and supports the removal of ammonia from the body. Aspartate, on the other hand, is involved in the transamination process, aiding in the conversion of ammonia to less toxic substances, thus reducing ammonia levels in the bloodstream. This combined action helps maintain ammonia homeostasis, making Ornithine Aspartate useful in managing conditions associated with elevated ammonia levels.

Ornithine Aspartate is a metabolic supplement.

Suspension

The following are the uses of Ornithine Aspartate Syrup/Suspension:

• Used for treating and preventing hepatic coma, a severe liver condition
• Used for managing hepatic encephalopathy, a brain disorder caused by liver disease
• Used to improve liver function and reduce ammonia levels in the blood
• Used to enhance recovery after liver surgery or liver-related complications
• Used to support patients with cirrhosis and associated symptoms
• Used to alleviate symptoms of hyperammonemia, a condition with high ammonia levels
• Used to improve overall liver health and reduce the risk of liver-related complications
• Used as a supplement to support patients with chronic liver disorders

In the case of an overdose of Ornithine Aspartate Syrup/Suspension, individuals may experience symptoms such as nausea, vomiting, diarrhea, and abdominal pain. The severity of these symptoms can vary depending on the amount ingested. It is important to seek medical advice promptly, as excessive consumption may lead to more serious health complications. Medical professionals should be informed about the specific details of the overdose, including the quantity consumed and the individual's medical history.

In the case of a missed dose of Ornithine Aspartate Syrup/Suspension, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your medication regimen.

To administer Ornithine Aspartate Syrup/Suspension, shake the bottle vigorously, then accurately measure the prescribed dose using a suitable measuring device like a dosing spoon or oral syringe, and take it orally as directed by your healthcare professional, typically one to three times a day, with or without food, following the dosage instructions provided.

Following are the conditions/situations when Ornithine Aspartate Syrup/Suspension should not be used:

• Should not be administered to individuals with a known hypersensitivity or allergy to Ornithine, Aspartate, or any of the excipients in the syrup/suspension.
• Contraindicated in patients with severe liver disease or liver failure.
• Not recommended for individuals with severe kidney disease or those on dialysis.
• Should not be used in patients with a history of seizures or epilepsy, as it may lower the seizure threshold.
• Contraindicated in patients with hereditary diseases affecting the urea cycle or ammonia metabolism.
• Not suitable for individuals with a history of mental health disorders, such as schizophrenia or bipolar disorder.
• Should be avoided in patients with a history of cardiovascular disease or those at risk of cardiovascular events.

The side effects of Ornithine Aspartate Syrup/Suspension may include:

• Nausea and vomiting
• Stomach pain or cramps
• Diarrhea
• Constipation
• Loss of appetite
• Fatigue and weakness
• Skin rash or itching
• Dizziness

Following are the precautions and warnings for Ornithine Aspartate Syrup/Suspension:

• This medication should not be used in patients with known hypersensitivity or allergy to Ornithine Aspartate or any of its excipients.
• Patients with severe liver disease should use this medication with caution, as it may cause a worsening of their condition. Regular monitoring of liver function is advised.
• Not recommended for use in patients with severe kidney disease, as it may lead to increased ammonia levels in the blood.
• Avoid alcohol consumption while taking Ornithine Aspartate, as it may decrease the effectiveness of the medication and increase the risk of side effects.
• May cause drowsiness or dizziness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Caution is advised for elderly patients, as they may be more susceptible to the medication's side effects.
• Always inform your healthcare provider about all the medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Ornithine Aspartate Syrup/Suspension:

• It may interact with other hepatotoxic drugs, increasing the risk of liver damage, especially when used with acetaminophen or other analgesics.
• Alcohol consumption should be avoided as it can increase the risk of liver toxicity.
• Use with caution in patients taking anti-seizure medications, as it may affect seizure control.
• Ornithine can affect the absorption of certain antibiotics, such as tetracyclines, reducing their effectiveness.
• The syrup may alter the effects of diabetes medications, requiring close monitoring of blood glucose levels.
• When combined with angiotensin-converting enzyme (ACE) inhibitors, it may increase the risk of hyperkalemia.
• Avoid concurrent use with immunosuppressants, as it may impact their efficacy.

Following are the food interactions for Ornithine Aspartate Syrup/Suspension:

• Alcohol intake should be limited or avoided as it can increase the burden on the liver and potentially affect the metabolism of Ornithine Aspartate, leading to reduced effectiveness.
• High-protein foods like meat, fish, eggs, and dairy products can be beneficial as they provide essential amino acids, supporting the liver's function and aiding in ammonia detoxification.
• Citrus fruits, particularly oranges and lemons, can be consumed as they are rich in vitamin C, which is an antioxidant and may help support liver health.
• Foods containing high levels of ammonia, such as certain seafood, aged/cured meats, and some vegetables (e.g., spinach, broccoli), should be consumed in moderation as they can increase the workload on the liver.
• Sugary foods and refined carbohydrates should be limited as they can contribute to increased ammonia production and may negatively impact liver function.
• Caffeine intake should be monitored as it is metabolized by the liver, and excessive consumption may increase the liver's workload.
• Well-balanced meals with a variety of fruits, vegetables, whole grains, and lean proteins can help maintain overall health and support the liver's function.
• It is advisable to stay hydrated by drinking adequate water, which can aid in liver function and overall detoxification processes.

Ornithine Aspartate Syrup/Suspension should be stored with utmost care, preferably in a cool and dry place, away from direct sunlight and moisture. Ensure the medication bottle is tightly sealed to maintain its integrity and prevent contamination. It is crucial to store the syrup at room temperature, avoiding extreme heat or cold. Always refer to the packaging for the exact storage conditions and expiration date. When it comes to disposal, never flush or pour the medication down the drain; instead, consult your pharmacist for the appropriate disposal method to minimize environmental impact. Keep the medication securely locked away from children to prevent accidental consumption.

Following are the quick tips for Ornithine Aspartate Syrup/Suspension:

• Administer the syrup as directed by your physician or healthcare professional.
• Measure the dose accurately using the measuring cup or syringe provided.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Ensure the syrup is within its expiration date before use.
• Do not freeze the suspension, as it may affect its potency.
• Avoid mixing the syrup with other medications unless advised by your doctor.
• Consult your healthcare provider if you have any concerns or experience side effects.