HEPALEX SYP

L-Ornithine L-Aspartate is a combination of two amino acids, L-ornithine and L-aspartic acid. Its mechanism of action primarily involves the detoxification of ammonia in the body. L-Ornithine plays a crucial role in the urea cycle, where it helps convert toxic ammonia into urea for excretion. When administered, L-Ornithine stimulates the urea cycle, promoting the conversion of ammonia to urea in the liver. L-Aspartate, on the other hand, acts as a precursor for the synthesis of another amino acid, arginine, which is also involved in the urea cycle. By increasing the availability of these amino acids, L-Ornithine L-Aspartate enhances the capacity of the urea cycle to eliminate excess ammonia, thereby reducing ammonia levels in the bloodstream. This mechanism is particularly relevant in conditions where ammonia accumulation can be harmful, such as in liver diseases or during episodes of hyperammonemia.

L-Ornithine, L-Aspartate

Ornithine aspartate.

Suspension

The following are the uses of L-Ornithine, L-Aspartate Syrup/Suspension:

• Used for enhancing athletic performance and reducing fatigue in athletes.
• Used to improve recovery after intense exercise or surgery.
• Used for boosting the immune system and promoting wound healing.
• Used for managing chronic liver diseases and improving liver function.
• Used for detoxifying the body by aiding in the removal of ammonia and waste products.
• Used for stimulating the release of growth hormones, which may have anti-aging effects.
• Used for promoting healthy skin and collagen production.
• Used to support overall metabolic health and energy production.

In the case of an overdose of L-Ornithine, L-Aspartate Syrup/Suspension, symptoms may include nausea, vomiting, diarrhea, and abdominal pain. Severe cases can lead to metabolic disturbances and neurological symptoms. Immediate treatment involves gastric lavage and supportive care, focusing on managing symptoms and stabilizing the patient's condition. Medical professionals should be contacted promptly for guidance and further treatment options.

In the case of a missed dose of L-Ornithine, L-Aspartate Syrup/Suspension, it is generally advised to take the missed dose as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. Consult your healthcare provider if you frequently miss doses to determine the best course of action.

To administer L-Ornithine, L-Aspartate Syrup/Suspension, shake the bottle vigorously, measure the prescribed dose using an accurate measuring device like a medicine cup or syringe, and take it orally, following the dosage instructions provided by your healthcare professional, which may include specific timing and frequency guidelines for optimal results.

Following are the conditions/situations when L-Ornithine, L-Aspartate Syrup/Suspension should not be used:

• Avoid use in patients with known hypersensitivity or allergy to L-Ornithine, L-Aspartate or any of its excipients.
• Not suitable for patients with severe liver disease or liver failure.
• Should not be used in individuals with a history of liver cirrhosis.
• Contraindicated in patients with severe kidney disease or kidney failure.
• Not recommended for individuals with a history of peptic ulcers or gastrointestinal bleeding.
• Do not administer to patients with hereditary diseases such as ornithine transcarbamylase (OTC) deficiency or hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome.
• Should not be used in patients with a history of systemic lupus erythematosus (SLE).
• Avoid use during an acute attack of porphyria, a metabolic disorder.

The side effects of L-Ornithine, L-Aspartate Syrup/Suspension may include:

• Nausea and vomiting
• Abdominal pain or discomfort
• Diarrhea
• Headache
• Dizziness
• Fatigue or weakness
• Skin rash or itching
• Altered taste

Following are the precautions and warnings for L-Ornithine, L-Aspartate Syrup/Suspension:

• Not suitable for individuals with a known hypersensitivity or allergy to L-ornithine, L-aspartate or any other ingredients in the syrup.
• Patients with liver or kidney disease should exercise caution and consult a healthcare professional before use, as the medication may need to be adjusted.
• Avoid alcohol consumption while taking this medication, as it may increase the risk of side effects.
• May cause drowsiness or dizziness; patients should avoid driving or operating heavy machinery until they know how this medication affects them.
• Not recommended for use in children under 12 years of age without medical supervision.
• If you have a history of gastrointestinal issues or are taking other medications, consult your doctor or pharmacist before use.
• Always read the patient information leaflet provided with the medication for full details on precautions and potential interactions.
• If you have any other medical conditions or concerns, consult your healthcare provider before taking L-Ornithine, L-Aspartate Syrup/Suspension.

Following are the drug interactions for L-Ornithine, L-Aspartate Syrup/Suspension:

• It may interact with other medications that affect ammonia levels in the body, such as those used for liver disease or certain antibiotics.
• Use with valproic acid or other anticonvulsants can potentially affect ammonia metabolism and require close monitoring.
• L-Ornithine, L-Aspartate may interact with drugs that are metabolized by the liver, possibly altering their effectiveness.
• Alcohol consumption should be avoided as it may increase the risk of adverse effects and impair liver function.
• It may affect the absorption and metabolism of amino acid-based medications or supplements.
• Caution is advised when using with medications that affect kidney function, as it may impact the elimination of waste products.
• This medication could potentially interact with medications that alter the pH of the urine, affecting its excretion.

Following are the food interactions for L-Ornithine, L-Aspartate Syrup/Suspension:

• Avoid excessive consumption of high-protein foods like red meat, poultry, and dairy while using this supplement, as it can increase the workload on the liver and kidneys.
• Maintain a balanced diet with a variety of fruits, vegetables, and whole grains to support overall health and liver function.
• Limit or avoid alcohol consumption, as alcohol can stress the liver and interfere with the supplement's effectiveness.
• Avoid grapefruit and grapefruit juice, as they may affect liver enzyme activity and alter the metabolism of certain compounds in the liver.
• Stay hydrated by drinking plenty of water to support kidney function and facilitate the elimination of waste products.
• Avoid high-sugar foods and beverages, as they can contribute to inflammation and liver stress.
• Consider consulting a dietician or healthcare provider for personalized dietary recommendations to support liver health during supplementation.

L-Ornithine, L-Aspartate Syrup/Suspension should be stored with caution to maintain its integrity and effectiveness. Keep the syrup in a cool and dry place, preferably at room temperature, ensuring it is not exposed to direct sunlight or moisture. The original container should be tightly sealed to prevent contamination. Avoid storing it in areas with temperature fluctuations like bathrooms or near heat sources, as this can impact the medication's quality. Dispose of any unused or expired syrup responsibly; do not flush it or pour it down the drain. Consult a pharmacist or healthcare professional for guidance on proper disposal methods, and keep the medication away from children to prevent accidental consumption.

Following are the quick tips for L-Ornithine, L-Aspartate Syrup/Suspension:

• Consult your healthcare provider for dosage instructions based on your specific needs.
• Ensure you understand the prescribed dosage and duration of treatment.
• Administer the syrup orally, following the recommended dosage guidelines.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Check the expiration date before using, and discard if expired.
• Avoid mixing with other medications without medical advice.
• Contact your doctor if you experience any unusual symptoms during treatment.
• Inform your healthcare provider about any other supplements or medications you are taking.