Hepcvir (400mg) 15 Tablets

Adefovir Dipivoxil 400mg Tablet primarily acts as a nucleoside reverse transcriptase inhibitor. It is metabolized in the body to adefovir, which is the active form of the drug. Adefovir competes with natural substrates for incorporation into the growing DNA chain by viral reverse transcriptase. Once incorporated, adefovir diphosphate terminates DNA chain elongation due to its lack of a 3'-hydroxyl group, thereby inhibiting the replication of hepatitis B virus (HBV). This mechanism effectively reduces the amount of HBV in the blood and improves liver function in patients with chronic hepatitis B.

Adefovir Dipivoxil 400mg

Nucleotide analogues

Tablet

The following are the uses of Adefovir Dipivoxil 400mg Tablet:

• Used for treating chronic hepatitis B virus infection
• Used to reduce viral load and improve liver health
• Used to prevent the virus from multiplying and infecting new liver cells
• Used to manage long-term symptoms and reduce liver damage
• Used as a long-term treatment option to control the disease
• Used to help patients achieve viral suppression and improved liver function
• Used for patients who have not responded well to other antiviral medications
• Used under the guidance of a specialist to monitor effectiveness and potential side effects

In the case of an overdose of Adefovir Dipivoxil 400mg Tablets, individuals may experience symptoms such as nausea, vomiting, and an increase in liver enzymes. It is important to seek medical advice promptly if an overdose is suspected. Treatment for overdose may involve supportive care and monitoring of vital signs, as well as managing any potential complications. Quick action can help mitigate the risks associated with an overdose of this medication.

In the case of a missed dose of Adefovir Dipivoxil 400mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one. Never take an extra dose to make up for a forgotten one. It's important to try to maintain a consistent schedule for taking this medication. If you frequently miss doses, consult your healthcare provider for advice on how to improve your medication adherence and ensure the effectiveness of the treatment.

To take Adefovir Dipivoxil 400mg Tablet, swallow the tablet whole with a full glass of water, preferably on an empty stomach, as directed by your healthcare professional, typically once daily at the same time each day.

Following are the conditions or situations when Adefovir Dipivoxil 400mg Tablet should not be taken:

• Avoid if you have a known allergy or hypersensitivity to Adefovir Dipivoxil or any of its components.
• Not recommended for individuals with severe kidney disease or those on dialysis.
• Contraindicated in patients with liver disease or severe liver impairment.
• Do not use if you have a history of liver problems or hepatitis after taking similar medications.
• Should not be used in children or adolescents under 18 years of age.
• Avoid if you are pregnant or breastfeeding, as it may cause harm to the baby.
• Do not take this medication if you have a history of kidney stones or any condition that increases your risk of kidney stones.

The side effects of Adefovir Dipivoxil 400mg Tablet may include:

• Nausea and vomiting
• Stomach pain
• Diarrhea
• Headache
• Fatigue and weakness
• Dizziness
• Skin rash
• Liver problems (rare)

Following are the precautions and warnings for Adefovir Dipivoxil 400mg Tablet:

• Not recommended for individuals with known hypersensitivity or severe allergic reactions to Adefovir or any of its excipients.
• Regular monitoring of kidney function is essential during treatment, and dosage adjustments may be required in patients with impaired renal function.
• Caution is advised in patients with underlying liver disease, as Adefovir can affect liver function.
• Patients should be advised to maintain adequate hydration and seek medical attention if signs of acute kidney injury or liver toxicity occur.
• Adefovir may cause lactic acidosis, a serious condition, and should be discontinued if symptoms such as nausea, vomiting, abdominal pain, and rapid breathing appear.
• Not recommended for use during pregnancy unless the potential benefits outweigh the risks. Breastfeeding should be avoided while using this medication.
• Patients should be aware of the potential risk of HIV resistance development with prolonged use and should adhere to prescribed treatment regimens.
• Regular monitoring of hepatitis B virus (HBV) DNA levels and liver function tests is recommended to assess treatment response and detect any viral breakthrough.

Following are the drug interactions for Adefovir Dipivoxil 400mg Tablet:

• Concurrent use with other nucleoside reverse transcriptase inhibitors (NRTIs) like tenofovir, lamivudine, or emtricitabine may increase the risk of renal toxicity and adverse effects on bone mineral density.
• Adefovir can decrease the effectiveness of probenecid, a medication used to treat gout, by reducing its concentration in the body.
• The efficacy of adefovir may be reduced by medications that increase renal elimination, such as certain nonsteroidal anti-inflammatory drugs (NSAIDs) and diuretics.
• Drugs that impair renal function, such as aminoglycoside antibiotics, can increase the serum levels of adefovir, potentially leading to increased toxicity.
• It is advised to monitor kidney function when combining Adefovir with other nephrotoxic drugs, as this may exacerbate kidney-related side effects.
• Adefovir may interact with certain antiviral medications, such as other nucleoside analogs, potentially affecting the therapeutic response.
• Co-administration with didanosine is not recommended due to increased risk of adverse events and toxicity.

Following are the food interactions for Adefovir Dipivoxil 400mg Tablet:

• Avoid excessive alcohol consumption while taking this medication, as alcohol can increase the risk of liver problems and may reduce the effectiveness of the treatment.
• Grapefruit and grapefruit juice should be consumed with caution. These can affect the metabolism of Adefovir, potentially leading to increased drug levels and an elevated risk of side effects.
• High-fat meals might delay the absorption of Adefovir, possibly affecting its efficacy. It's advisable to maintain a consistent diet pattern when taking this medication.
• Avoid taking herbal supplements, especially those containing St. John's Wort, as they can interfere with the medication's effectiveness.
• Ensure adequate hydration by drinking plenty of fluids to maintain kidney health, as Adefovir may impact kidney function.
• Limit caffeine intake, as it can potentially interact with Adefovir and increase nervous system side effects.
• Consult a healthcare professional for personalized advice regarding dietary restrictions and recommendations specific to your health condition.

Adefovir Dipivoxil 400mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or storage area at room temperature, ensuring it remains protected from moisture, heat, and direct sunlight. It is crucial to keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent contamination. Always verify the expiration date on the packaging, and do not use the medication if it has expired. When disposing of unused or expired tablets, do not flush them down the toilet or sink. Instead, follow local guidelines or consult your pharmacist for safe disposal methods to protect the environment and prevent misuse. Keep the medication out of children's reach to ensure their safety and prevent accidental ingestion.

Following are the quick tips for Adefovir Dipivoxil 400mg Tablet:

• Consult your doctor for personalized advice and dosage instructions.
• Take the tablet as directed, ensuring you understand the prescribed frequency.
• Swallow the tablet whole; do not crush or chew for optimal absorption.
• Maintain a consistent daily routine for taking the medication.
• Avoid missing doses; if you miss one, take it as soon as you remember, unless it's close to the next dose.
• Do not double the dose to make up for a missed one; continue with your regular schedule.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.