Hepsera (10mg) 30 Tablets

Adefovir Dipivoxil 10mg Tablet, a prodrug of adefovir, primarily acts by inhibiting the reverse transcriptase enzyme, a crucial component of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) replication. Upon entering the body, Adefovir Dipivoxil is metabolized to its active form, adefovir, which directly targets and blocks the reverse transcriptase enzyme. This enzyme is responsible for converting viral RNA into DNA, a critical step in the viral replication cycle. By binding to the active site of the reverse transcriptase, adefovir prevents the enzyme from functioning properly, thus inhibiting the synthesis of viral DNA. This mechanism effectively disrupts the replication process of HIV and HBV, leading to a reduction in viral load and slowing down the progression of these viral infections.

Adefovir Dipivoxil 10mg

Nucleoside reverse transcriptase inhibitor

Tablet

The following are the uses of Adefovir Dipivoxil 10mg Tablet:

• Used for treating chronic hepatitis B virus (HBV) infection in adults
• Used to reduce the amount of HBV in the body
• Used to improve liver function and reduce the risk of liver damage
• Used for long-term suppression of HBV replication
• Used to reduce the risk of liver cancer and other complications related to chronic HBV infection
• Used as a second-line treatment option for patients who cannot tolerate or have resistance to other antiviral medications
• Used to manage HBV infection in combination with other therapies as part of a comprehensive treatment plan

In the case of an overdose of Adefovir Dipivoxil 10mg Tablets, individuals may experience symptoms such as nausea, vomiting, diarrhea, and abdominal pain. It is important to seek medical advice immediately if an overdose is suspected. Treatment for overdose may involve supportive care and monitoring of vital signs, as well as managing any potential complications. Prompt medical intervention can help mitigate the severity of the overdose and ensure the well-being of the individual.

In the case of a missed dose of Adefovir Dipivoxil 10mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. It is crucial to maintain a consistent dosing routine for this medication, so aim to take it at the same time each day. If you frequently miss doses, consult your healthcare provider for advice on how to improve your medication adherence.

To take Adefovir Dipivoxil 10mg Tablet, swallow the tablet whole with a full glass of water, preferably on an empty stomach, following the dosage instructions provided by your healthcare professional, typically once a day or as directed.

Here are the conditions or situations when Adefovir Dipivoxil 10mg Tablet should not be used:

• Must not be used in individuals with a known hypersensitivity or allergy to Adefovir Dipivoxil or any of its ingredients.
• Not recommended for patients with severe kidney disease or those on dialysis.
• Contraindicated in patients with a history of liver disease or liver problems caused by previous hepatitis B medications.
• Should not be used during pregnancy or breastfeeding, as it may cause harm to the unborn baby or infant.
• Avoid using in children and adolescents under 18 years of age, as the safety and efficacy have not been established in this age group.
• Do not use if you have a known resistance to Adefovir or other similar medications.
• Not suitable for individuals with HIV or hepatitis C virus (HCV) infection.

The side effects of Adefovir Dipivoxil 10mg Tablet may include:

• Nausea and vomiting
• Stomach pain
• Diarrhea
• Headache
• Dizziness
• Fatigue and weakness
• Skin rash or itching
• Joint pain

Following are the precautions and warnings for Adefovir Dipivoxil 10mg Tablet:

• Not recommended for individuals with known hypersensitivity or severe allergic reactions to Adefovir Dipivoxil or any of its excipients.
• Patients with kidney impairment require close monitoring, and dosage adjustments might be necessary.
• Caution should be exercised when using Adefovir Dipivoxil with other medications, especially those affecting kidney function.
• Regular monitoring of kidney function and liver enzymes is essential during treatment.
• Patients should be advised to maintain adequate hydration while taking this medication.
• Not intended for use in children or adolescents under 18 years of age.
• Consult a healthcare professional before use if you are pregnant, planning to become pregnant, or breastfeeding.
• Do not share this medication with others, even if they have similar symptoms, as it may cause harm.

Following are the drug interactions for Adefovir Dipivoxil 10mg Tablet:

• Probenecid can significantly increase the exposure of adefovir, potentially leading to increased risk of adverse effects.
• Co-administration with tenofovir should be avoided due to the risk of additive nephrotoxicity.
• Adefovir may reduce the efficacy of antacids; hence, antacids should be taken at least 2 hours before or after Adefovir Dipivoxil.
• Didanosine may increase the exposure of adefovir, requiring close monitoring for toxicity.
• Lamivudine and emtricitabine may decrease the effectiveness of adefovir, necessitating careful observation for treatment response.
• Drugs that decrease renal function can increase the concentration of adefovir, potentially leading to increased toxicity.
• Adefovir may reduce the absorption of certain HIV protease inhibitors, requiring monitoring of protease inhibitor levels.

Following are the food interactions to be aware of when taking Adefovir Dipivoxil 10mg Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can lead to increased blood levels of Adefovir, potentially causing higher side effects and toxicity.
• Alcohol intake should be limited as it may increase the risk of liver problems and worsen existing liver conditions, especially in patients with hepatitis B.
• High-fat meals might slightly delay the absorption of Adefovir, but this is generally not clinically significant and does not require timing adjustments.
• Ensure adequate hydration, as Adefovir can cause kidney issues and staying well-hydrated may help reduce the risk of kidney-related side effects.
• Avoid taking antacids containing aluminum or magnesium within 2 hours of Adefovir, as they may decrease its absorption.
• Do not consume large amounts of caffeinated beverages, as caffeine may interact with Adefovir and increase its side effects, particularly on the nervous system.
• Follow a healthy diet as directed by your healthcare provider to support overall liver health during Adefovir treatment.
• Always adhere to the instructions provided by your healthcare professional regarding food and medication interactions.

Adefovir Dipivoxil 10mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet, at room temperature, maintaining a consistent temperature range between 68°F and 77°F (20°C and 25°C). Ensure the tablets are kept in their original packaging, tightly sealed, to protect them from moisture and light. It is crucial to keep the medication away from children and pets to prevent accidental ingestion. When disposing of unused or expired tablets, do not flush them down the toilet or throw them into the trash. Instead, contact your pharmacist or local waste management authority for guidance on proper disposal methods to ensure environmental safety.

Following are the quick tips for Adefovir Dipivoxil 10mg Tablet:

• Take the tablet as directed by your doctor; do not adjust the dosage without medical advice.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Maintain a consistent medication schedule by taking it at the same time each day.
• Ensure you complete the full prescribed course, even if you feel better early on.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Regularly monitor your kidney and liver function while on this medication.
• Store the tablets at room temperature, away from moisture and heat.