Hitaxime (250mg) 1 Vial Injection

Ranitidine 250mg injection works by specifically blocking histamine H2 receptors in the stomach, which inhibits the production of gastric acid. It selectively suppresses the activity of gastric parietal cells, reducing both the basal and stimulated gastric acid secretion. This mechanism of action helps in decreasing the overall acidity in the stomach, providing relief from conditions associated with excess acid production. The selective inhibition of histamine H2 receptors makes Ranitidine effective in reducing symptoms related to acid reflux, peptic ulcers, and other acid-related disorders.

Histamine H2-receptor antagonist.

Injection

The following are the uses of Ranitidine 250mg injection:

• Used for reducing stomach acid production and treating acid reflux.
• Used for managing heartburn and relieving pain in the upper abdomen.
• Used for healing and preventing stomach and duodenal ulcers.
• Used for treating gastroesophageal reflux disease (GERD) and its symptoms.
• Used for managing conditions where the stomach produces too much acid.
• Used for providing relief from acid-related discomfort and inflammation.
• Used for preventing acid-induced damage to the esophagus.

In the case of an overdose of Ranitidine 250mg injection, it is important to seek medical advice promptly. Symptoms may include nausea, vomiting, abdominal pain, and dizziness. Treatment for overdose involves supportive care, monitoring vital signs, and providing necessary medical interventions. Prompt medical assessment is crucial to ensure appropriate management and prevent potential complications associated with excessive medication administration. Timely action can help mitigate the risks and ensure the best possible outcome.

In the case of a missed dose of Ranitidine 250mg injection, it is important to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. However, do not double the dose to make up for the missed one. If you have missed multiple doses, contact your healthcare provider for guidance on how to safely resume the medication. It is recommended to set reminders or use a medication tracker to help prevent missed doses in the future.

To administer Ranitidine 250mg injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and slowly inject the prescribed volume of medication into the muscle, ensuring the entire dose is delivered as directed by your healthcare provider.

Here are the conditions or situations when Ranitidine 250mg injection should not be used:

• Must not be administered if the patient has a known allergy or hypersensitivity to Ranitidine or other similar H2-receptor antagonists.
• Contraindicated in patients with a history of acute porphyria, as it can trigger or worsen the condition.
• Should not be used in patients with severe liver impairment or liver failure, as the metabolism of the drug may be affected.
• Not recommended for patients with a history of long-term kidney dialysis.
• Avoid using in patients with a history of lung diseases or conditions like chronic obstructive pulmonary disease (COPD) or asthma.
• Not suitable for patients with a slow or irregular heartbeat (cardiac arrhythmias).
• Should not be administered if the patient has a history of low blood platelet counts (thrombocytopenia).

The side effects of Ranitidine 250mg Injection may include:

• Headache
• Diarrhea
• Constipation
• Nausea and vomiting
• Dizziness
• Skin rashes or itching
• Joint pain
• Confusion (especially in elderly patients)

Following are the precautions and warnings for Ranitidine 250mg injection:

• Do not use if you are allergic to Ranitidine or similar medications.
• Ranitidine should be used with caution in patients with kidney or liver disease, as dosage adjustments may be necessary.
• Elderly patients may be more sensitive to the effects of Ranitidine, so caution is advised.
• This medication may interact with other drugs, including those used for blood thinning, so inform your doctor about all medications you are taking.
• Avoid alcohol consumption while using Ranitidine, as it may increase the risk of certain side effects.
• Patients with a history of lung diseases, such as asthma or chronic obstructive pulmonary disease (COPD), should be monitored closely.
• If you have a history of porphyria, a rare blood disorder, consult your doctor before using Ranitidine.

Following are the drug interactions for Ranitidine 250mg injection:

• Concomitant use with antacids may reduce the effectiveness of ranitidine by altering stomach pH, reducing its absorption.
• Warfarin levels may be increased with ranitidine, potentially enhancing its anticoagulant effects and increasing the risk of bleeding.
• Cimetidine or other H2 blockers may interact with ranitidine, leading to an additive effect, increasing the risk of side effects like dizziness or confusion.
• Theophylline levels may increase with ranitidine, as ranitidine can inhibit its metabolism, potentially leading to toxicity.
• Ketoconazole or other antifungals may have reduced absorption when used with ranitidine due to changes in stomach pH.
• Phenytoin levels may be increased when combined with ranitidine, increasing the risk of toxicity.
• Tricyclic antidepressants (e.g., amitriptyline) may have enhanced sedative effects when used with ranitidine.

Following are the food interactions to be aware of with Ranitidine 250mg injection:

• Avoid consuming alcohol as it can increase the risk of adverse effects and may reduce the effectiveness of Ranitidine.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Ranitidine, potentially leading to increased levels in the blood.
• Caffeine-containing beverages like coffee and tea may increase stomach acid production and reduce the efficacy of Ranitidine.
• Spicy foods can irritate the stomach and potentially reduce the effectiveness of the medication.
• High-fat meals may delay the absorption of Ranitidine, affecting its onset of action.
• Dairy products, especially milk, can interact with Ranitidine, reducing its absorption. Consider separating the medication and dairy intake by a few hours.
• Avoid large meals; instead, opt for smaller, more frequent meals to reduce stomach acid production and support the medication's effectiveness.
• Certain foods like chocolate, mint, and onions can relax the lower esophageal sphincter, potentially worsening acid reflux symptoms.

Ranitidine 250mg injection should be stored in a controlled environment, preferably in a cool and dry place, ensuring it remains below 25°C (77°F). Protect the injection from direct sunlight and do not freeze it, as temperature fluctuations can impact its efficacy. Store it in its original packaging, ensuring the container remains sealed to maintain sterility. Pay close attention to the expiration date, and do not use the injection beyond this date. When disposing of unused or expired Ranitidine injection, do not throw it in the trash or pour it down the drain. Contact your healthcare provider or pharmacist for instructions on safe disposal methods to minimize environmental impact. Keep the injection out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Ranitidine 250mg Injection:

• Administer the injection under medical supervision as prescribed.
• Ensure the injection is prepared and stored as per instructions.
• Follow the prescribed dosage and administration schedule.
• Do not self-inject; seek medical assistance for proper administration.
• Inform your doctor about any allergies or medical conditions.
• Report any unusual reactions or side effects promptly.
• Store the injection as directed, away from direct sunlight and moisture.