Hitaxime (500mg) 1 Vial Injection

Ranitidine 500mg injection works by specifically blocking histamine H2 receptors in the stomach, which inhibits the production of gastric acid. It is a potent and selective H2 receptor antagonist, targeting the H2 receptors on parietal cells. By blocking these receptors, ranitidine effectively reduces the secretion of hydrochloric acid, thereby decreasing gastric acidity. This mechanism of action provides relief from symptoms associated with excess stomach acid, such as heartburn, acid reflux, and peptic ulcers, without directly affecting the central nervous system or other histamine receptors in the body.

Histamine-2 receptor antagonist.

Injection

The following are the uses of Ranitidine 500mg injection:

• Used for treating stomach and duodenal ulcers, providing relief from pain and promoting healing.
• Used to manage gastroesophageal reflux disease (GERD) by reducing acid production and preventing acid reflux.
• Used in the treatment of Zollinger-Ellison syndrome, effectively controlling excessive acid secretion.
• Used to alleviate heartburn and acid indigestion, offering quick symptom relief.
• Used as a preventive measure for acid-related damage during anesthesia and surgery.
• Used to manage conditions like stress ulcers and upper gastrointestinal bleeding, aiding in reducing acid-related complications.
• Used to enhance patient comfort and recovery in various medical procedures.

In the case of an overdose of Ranitidine 500mg injection, symptoms may include severe drowsiness, rapid or irregular heartbeat, and difficulty breathing. It is important to recognize that an overdose can lead to a medical emergency, particularly in individuals with pre-existing heart or lung conditions. Promptly seek medical advice if an overdose is suspected, as early intervention can help manage potential complications and ensure the well-being of the patient. Timely medical assessment and appropriate treatment are essential in such situations.

In the case of a missed dose of Ranitidine 500mg injection, it is important to administer the medication as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. If you have missed multiple doses, contact your healthcare provider for guidance on how to resume the medication safely. It is advisable to set reminders or alarms to help you remember to take your medication on time.

To administer the Ranitidine 500mg injection, draw the medication into a syringe, ensuring the prescribed dose, and inject it into the muscle or intravenous route as directed by your healthcare provider, following the recommended dosage and administration guidelines provided by the manufacturer.

Following are the conditions when Ranitidine 500mg injection should not be administered:

• Should not be given to patients with a known allergy or hypersensitivity to Ranitidine or other similar H2-receptor antagonists.
• Contraindicated in patients with a history of acute porphyria, as it can trigger an attack.
• Not recommended for patients with severe kidney disease or those on dialysis, as dosage adjustments are necessary.
• Should not be used in patients with a history of long-QT syndrome or other heart rhythm disorders.
• Contraindicated during breastfeeding, as Ranitidine can pass into breast milk.
• Not suitable for patients with a history of drug-induced thrombocytopenia or agranulocytosis.
• Should not be administered to patients with a history of acute lung injury or pulmonary fibrosis.

The side effects of Ranitidine 500mg injection may include:

• Headache
• Dizziness
• Diarrhea
• Constipation
• Abdominal pain
• Fatigue
• Skin rashes
• Joint pain

Following are the precautions and warnings:

• Ranitidine 500mg injection should be used with caution in patients with impaired kidney function, as dosage adjustments may be necessary.
• Avoid using this medication if you have a known allergy to ranitidine or other similar medications.
• It is important to inform your doctor about any other medications you are taking, especially those affecting liver enzymes, as ranitidine is primarily metabolized by the liver.
• Patients with a history of liver disease should exercise caution and undergo regular liver function tests while using this medication.
• This injection should be administered by a healthcare professional, and any signs of an allergic reaction should be reported immediately.
• Elderly patients may be more susceptible to the side effects of ranitidine; close monitoring is advised.
• Pregnant and breastfeeding women should consult their doctor before using this medication, as it may pass into breast milk.
• Do not use this injection if the solution is discolored or contains particles, and ensure it is administered before the expiration date.

Following are the drug interactions for Ranitidine 500mg injection:

• Ranitidine can increase the concentration of Triazolam, potentially leading to prolonged sedation and impaired motor skills.
• When combined with certain antibiotics like Erythromycin, the effect of Ranitidine on heart rhythm may be enhanced, increasing the risk of QT prolongation.
• The anticoagulant effect of Warfarin can be reduced by Ranitidine, potentially requiring adjustment of Warfarin dosage.
• Propranolol's bioavailability may be increased by Ranitidine, leading to enhanced beta-blockade effects.
• Ranitidine can decrease the absorption of certain antifungal medications like Ketoconazole, potentially reducing their effectiveness.
• It may reduce the metabolism of Diazepam, resulting in increased sedation and potential respiratory depression.
• Caution is advised when using Ranitidine with antacids, as it may alter the absorption of both drugs.

Following are the food interactions for Ranitidine 500mg injection:

• Avoid consuming alcohol during the treatment with Ranitidine, as it can increase the risk of side effects and may reduce the effectiveness of the medication.
• Grapefruit and its juice should be consumed with caution as it may interfere with the metabolism of Ranitidine, potentially leading to increased drug levels in the body.
• Caffeine-containing beverages like coffee, tea, and energy drinks might enhance the production of stomach acid, potentially reducing the efficacy of Ranitidine.
• Spicy foods may irritate the stomach and potentially increase acid production, which could reduce the effectiveness of Ranitidine in controlling acid-related symptoms.
• High-fat meals may delay the absorption of Ranitidine, potentially affecting the timing of its peak effectiveness.
• Dairy products, especially milk, might interact with Ranitidine, forming insoluble complexes that can reduce the drug's absorption. Consuming them together should be avoided.
• Avoid excessive consumption of sugar, especially from sugary drinks and snacks, as they can promote inflammation and potentially delay the healing of stomach ulcers.

Ranitidine 500mg injection should be stored in a controlled environment, preferably in a designated medication storage area. Keep the injections in a cool, dry place, maintaining a temperature between 20°C and 25°C (68°F to 77°F). Protect the injections from direct sunlight, as light exposure can degrade the medication. Ensure the vials are stored in their original packaging to maintain sterility and prevent contamination. When disposing of unused or expired injections, do not throw them into the regular trash or pour them down the drain. Contact your healthcare provider or pharmacist for guidance on proper disposal methods to ensure environmental safety. It is crucial to keep all medications, including Ranitidine injections, out of the sight and reach of children to prevent accidental exposure.

Following are the quick tips for Ranitidine 500mg Injection:

• Administer the injection under medical supervision for accurate dosage and administration.
• Ensure the injection is prepared and stored as per the manufacturer's instructions.
• Ranitidine may be given intravenously or intramuscularly, follow the prescribed route.
• Check the expiry date before use and discard if expired.
• Clean the injection site with an antiseptic before administration.
• Report any signs of allergic reaction or severe side effects immediately to your doctor.
• Do not mix Ranitidine with other medications unless instructed by a healthcare professional.