HITICA TAB 90MG

Ticagrelor is a P2Y12 inhibitor, a class of antiplatelet medications that work by blocking the P2Y12 receptors on platelets. Its mechanism of action involves the inhibition of platelet activation and aggregation. When activated, platelets release adenosine diphosphate (ADP), which binds to the P2Y12 receptors, leading to further platelet activation and aggregation. Ticagrelor specifically binds to the P2Y12 receptors, preventing ADP from binding and thereby inhibiting platelet activation and aggregation. This action helps to prevent the formation of blood clots, which is crucial in reducing the risk of cardiovascular events such as heart attacks and strokes in patients with certain cardiovascular conditions.

Antiplatelet agent

Tablet

The following are the uses of Ticagrelor 90mg Tablet:

• Used for reducing the risk of stroke and heart attacks in patients with a history of these conditions.
• Used for treating acute coronary syndrome, a condition where blood supply to the heart is suddenly blocked.
• Used for preventing blood clots in patients with poor blood flow to the limbs, reducing the risk of amputation.
• Used for managing conditions like peripheral artery disease, improving blood circulation.
• Used for long-term prevention of blood clots after a heart attack or stent placement.
• Used for maintaining blood flow and preventing serious cardiovascular events.
• Used for managing conditions where blood clots may form in the legs and travel to the lungs.

To be used as per doctor's prescription

In the case of an overdose of Ticagrelor 90mg Tablets, immediate medical attention is necessary. The specific treatment for an overdose may vary depending on the amount ingested and the individual's health condition. Symptoms of an overdose could include excessive bleeding, prolonged bleeding from wounds, easy bruising, or blood in the urine or stools. It is important to seek emergency medical care if an overdose is suspected, as prompt treatment can help manage the symptoms and prevent potential complications.

In the case of a missed dose of Ticagrelor 90mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you have missed multiple doses, consult your healthcare professional for advice on how to resume your medication safely. It is recommended to set reminders or use a pill organizer to help you stay on track with your medication regimen.

To take Ticagrelor 90mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, as directed by your healthcare professional, usually twice daily, with or without food.

Following are the conditions/situations when Ticagrelor 90mg Tablet should not be taken:

• Do not take this medication if you have active bleeding or a history of bleeding disorders, such as intracranial hemorrhage or bleeding diathesis.
• It is contraindicated in patients with severe liver disease or liver impairment.
• Do not use Ticagrelor if you have a history of allergy or severe hypersensitivity reactions to the medication or any of its components.
• Avoid using this medication if you have a history of lung diseases or respiratory disorders, such as severe asthma or chronic obstructive pulmonary disease (COPD).
• Ticagrelor is not recommended for individuals with severe kidney disease or end-stage renal disease.
• Do not take this medication if you have a history of intracranial bleeding, brain tumors, or arteriovenous malformations.
• It should not be used in patients with severe low blood pressure or uncontrolled hypertension.
• Do not stop taking Ticagrelor suddenly without medical advice, as it may increase the risk of blood clots.

The side effects of Ticagrelor 90mg Tablet may include:

• Easy bruising or bleeding (nosebleeds, bleeding gums)
• Shortness of breath, rapid heart rate, or chest pain
• Feeling faint or lightheaded
• Unusual tiredness or weakness
• Paleness or cold feeling in your hands and feet
• Headache or dizziness
• Stomach pain, nausea, or diarrhea

Following are the precautions and warnings for Ticagrelor 90mg Tablet:

• Not recommended for individuals with a history of severe hepatic impairment or active pathological bleeding.
• Patients with a history of intracranial hemorrhage or severe, uncontrolled hypertension should use with caution.
• May increase the risk of bleeding, especially when combined with other antiplatelet or anticoagulant medications.
• Patients should inform their doctor about all medications they are taking to avoid potential drug interactions.
• Ticagrelor can cause bradycardia; monitor heart rate and blood pressure regularly.
• Discontinuation of the medication should be gradual to reduce the risk of adverse events.
• Patients should seek immediate medical attention if they experience signs of an allergic reaction or significant bleeding.

Following are the drug interactions for Ticagrelor 90mg Tablet:

• Rifampin can reduce the effectiveness of Ticagrelor, leading to decreased platelet inhibition.
• Use with strong CYP3A inhibitors like ketoconazole or ritonavir can increase Ticagrelor blood levels, potentially raising bleeding risks.
• CYP3A inducers such as carbamazepine or phenytoin may decrease Ticagrelor plasma concentrations, reducing its antiplatelet effects.
• The combination with aspirin enhances antiplatelet activity but may also increase bleeding risks.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) might elevate the likelihood of bleeding when taken with Ticagrelor.
• Ticagrelor may increase the effects of certain anticoagulants, requiring careful monitoring.
• Proton pump inhibitors (PPIs) like omeprazole can reduce the bioavailability of Ticagrelor, potentially decreasing its effectiveness.

Following are the food interactions for Ticagrelor 90mg Tablet:

• Avoid grapefruit and grapefruit juice as they can increase the levels of Ticagrelor in the blood, potentially leading to increased bleeding risks.
• Alcohol consumption should be limited as it can affect platelet function and increase the risk of bleeding when combined with Ticagrelor.
• Avoid cranberry juice as it may interfere with the metabolism of Ticagrelor, altering its effectiveness.
• Green leafy vegetables rich in vitamin K, like spinach and kale, should be consumed consistently to maintain a balanced diet, as Ticagrelor may impact vitamin K absorption.
• Avoid excessive garlic consumption, as it can have mild blood-thinning effects and potentially increase bleeding risks when combined with Ticagrelor.
• Maintain a consistent intake of foods containing tyramine, such as aged cheeses, cured meats, and fermented foods, as Ticagrelor may affect the metabolism of tyramine.
• Consult your healthcare provider for dietary advice, especially if you have specific dietary restrictions or health conditions that may require adjustments.

Ticagrelor 90mg Tablets should be stored in a dry and cool place, preferably at room temperature (around 25°C), ensuring protection from light and moisture. The original container should be tightly sealed to maintain its integrity and prevent exposure to environmental factors. It is crucial not to store the medication in bathrooms or areas with temperature fluctuations, like near stoves or heaters, as this can impact its effectiveness. Disposal of unused or expired tablets should be done responsibly; do not flush them or throw them into the trash. Contact your pharmacist or local waste management authorities for guidance on safe disposal practices, ensuring that the medication does not contaminate the environment. Keep the tablets away from children to prevent accidental ingestion.

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Following are the quick tips for Ticagrelor 90mg Tablet:

• Take the tablet as directed by your doctor, usually twice daily.
• Consume the tablet whole with a glass of water, do not crush or chew.
• Maintain a consistent schedule for taking the medication.
• Avoid grapefruit and grapefruit juice during treatment.
• Inform your doctor about all medications and supplements you are taking.
• Do not stop taking the medication without consulting your doctor.
• Store the tablets in a cool, dry place, away from sunlight and moisture.
• Regularly monitor your progress and report any unusual symptoms to your healthcare provider.