Humalog Kwikpen (3mg/ml) 3ml, 5 Injection Pens

Insulin lispro has a unique mechanism of action compared to regular human insulin. It is a rapid-acting insulin analog designed to have a faster onset of action and a shorter duration of effect. When injected subcutaneously, insulin lispro undergoes rapid absorption into the bloodstream. Its structure, which involves an inversion of the amino acid sequence at positions B28 and B29, allows it to dissociate more quickly into monomers upon injection. This rapid dissociation enables insulin lispro to bind rapidly to insulin receptors on cells, leading to an accelerated initiation of glucose uptake. As a result, insulin lispro starts lowering blood glucose levels within minutes after injection, making it particularly useful in managing postprandial hyperglycemia in individuals with diabetes. The quick onset and short duration of action provide better control over blood glucose levels, allowing for more flexibility in timing meals and insulin administration.

Insulin lispro

Rapid-acting insulin analog.

injection

The following are the uses of Insulin lispro Injection:

• Used for treating type 1 diabetes in adults and children.
• Used for managing blood sugar levels after meals in type 1 and type 2 diabetes patients.
• Used for improving blood sugar control in insulin-dependent diabetics.
• Used for providing rapid-acting insulin replacement to regulate glucose metabolism.
• Used for reducing hyperglycemia in diabetes mellitus.
• Used for enhancing the effectiveness of long-acting insulin analogs.
• Used for facilitating flexible insulin therapy and blood glucose monitoring.

To be taken as per doctor's prescription

In the case of an overdose of Insulin lispro Injection, it is important to recognize the potential symptoms, which may include hypoglycemia, characterized by symptoms such as sweating, dizziness, and confusion. Prompt action should be taken by administering fast-acting glucose sources like glucose tablets or juice. If symptoms persist or worsen, seek medical assistance immediately. Close monitoring of blood glucose levels is essential during this time to ensure a quick and effective response.

In the case of a missed dose of Insulin lispro Injection, it is important to administer the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you frequently miss doses or are unsure about how to adjust your dosing, consult your healthcare provider for guidance on managing your insulin therapy effectively.

To administer the Insulin lispro injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle into the skin, inject the prescribed dose slowly, and then gently remove the needle while applying pressure to the site with a cotton ball if needed.

Here are the situations when Insulin lispro Injection should not be used:

• Must not be taken if you are allergic to insulin lispro or any other ingredients in the injection.
• Avoid using it if you have experienced episodes of low blood sugar (hypoglycemia) and cannot identify the symptoms yourself.
• Not suitable for individuals with diabetic ketoacidosis.
• Should not be used if you are consuming alcohol or have a history of alcohol abuse.
• Contraindicated in individuals with severe kidney or liver disease.
• Not recommended for individuals with hypersensitivity to other insulin products.
• Avoid using if you have an infection or illness, as insulin needs may change during these times.
• Should not be used if you are taking certain medications, such as monoamine oxidase inhibitors (MAOIs) or oral diabetes medications, without proper medical adjustment.

The side effects of Insulin lispro Injection may include:

• Low blood sugar (hypoglycemia)
• Injection site reactions (such as redness, swelling, or itching)
• Skin reactions (such as rash, itching, or hives)
• Weight gain
• Headache
• Dizziness or lightheadedness
• Anxiety or nervousness
• Blurred vision

Following are the precautions and warnings for Insulin lispro Injection:

• Do not share insulin pens or syringes with others to prevent the transmission of infectious diseases.
• Insulin lispro should be used with caution in individuals with kidney or liver disease, as dosage adjustments may be necessary.
• Hypoglycemia (low blood sugar) is a potential risk; monitor blood glucose levels regularly and recognize the symptoms of hypoglycemia.
• Adjust dosage carefully during illness, travel, or changes in activity level, as these factors can affect blood sugar control.
• Elderly patients may require closer monitoring and dosage adjustments due to age-related changes in insulin sensitivity.
• If using Insulin lispro with other insulin products, ensure proper injection technique and accurate dosing to avoid medication errors.
• Consult a healthcare professional if experiencing difficulty achieving blood sugar control or if experiencing frequent episodes of hypoglycemia.

Following are the drug interactions for Insulin lispro Injection:

• Thiazolidinediones (TZDs) like pioglitazone or rosiglitazone can cause fluid retention, which may lead to or exacerbate heart failure when used with insulin lispro.
• Beta-blockers, such as propranolol, may mask the symptoms of hypoglycemia and prolong the effect of insulin lispro.
• ACE inhibitors like lisinopril may enhance the blood glucose-lowering effect of insulin lispro, increasing the risk of hypoglycemia.
• Octreotide and lanreotide can decrease insulin requirements, leading to hypoglycemia when used with insulin lispro.
• Oral contraceptives and estrogen therapies can alter blood glucose levels, requiring insulin lispro dose adjustments.
• Alcohol can cause unpredictable changes in blood glucose levels, and caution is advised when using with insulin lispro.
• SGLT2 inhibitors (sodium-glucose co-transporter 2 inhibitors) may increase the risk of diabetic ketoacidosis, especially in conditions like dehydration or reduced food intake.

Following are the food interactions for Insulin lispro Injection:

• Alcohol consumption should be limited as it can affect blood sugar levels and may interfere with the effectiveness of the medication.
• Avoid excessive consumption of sugary foods and beverages as they can cause rapid increases in blood glucose levels.
• Consume a balanced diet with consistent carbohydrate intake to optimize blood sugar control.
• Avoid high-fat meals as they may delay the absorption of insulin lispro, affecting its onset of action.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect blood glucose levels and interact with the medication's metabolism.
• Monitor blood glucose levels closely when making dietary changes, especially when including high-fiber foods, as they can impact insulin requirements.
• Always follow the dietary guidelines provided by your healthcare professional for optimal diabetes management.
• No significant food interactions are known to directly interfere with the absorption of Insulin lispro.

Insulin lispro injection storage and disposal require careful attention to maintain its effectiveness and ensure safety. Store unopened vials or prefilled pens in the refrigerator between 2°C and 8°C (36°F and 46°F), protecting them from freezing. If refrigerated, unused insulin lispro can be kept until the expiration date printed on the package. Once opened, vials should be kept at room temperature, not exceeding 25°C (77°F), and used within 28 days. Prefilled pens can be stored at room temperature for up to 28 days after the first use. Avoid exposing the medication to direct sunlight or extreme heat. Proper disposal of insulin lispro is crucial; do not throw away or flush it down the toilet. Consult your pharmacist or local waste disposal company for specific instructions on how to safely dispose of used needles, syringes, and any remaining medication, ensuring compliance with local regulations.

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Following are the quick tips for Insulin lispro Injection:

• Consult your doctor for the correct dosage and usage instructions tailored to your medical needs.
• Ensure you understand the injection technique; ask your healthcare provider for guidance if needed.
• Rotate injection sites to minimize the risk of lipodystrophy (changes in fat tissue).
• Monitor blood glucose levels regularly as directed by your healthcare provider.
• Do not share your injection pen or syringe with others to prevent infections.
• Dispose of used needles and syringes safely in a puncture-proof container.
• Store insulin lispro as recommended; protect it from extreme temperatures.