HUMALOG MIX 75/25 KWIKPEN 100U

Insulin lispro is a rapid-acting insulin analog designed to have a faster onset of action compared to regular human insulin. It is modified in such a way that it forms fewer hexamers, allowing for quicker absorption into the bloodstream. This modification enables insulin lispro to start reducing blood glucose levels within minutes of injection. Insulin lispro protamine suspension, on the other hand, is a combination of insulin lispro and protamine, which slows down the absorption of insulin lispro, providing a prolonged duration of action. This combination allows for both rapid onset and sustained blood glucose control, making it suitable for managing postprandial glucose levels.

Insulin lispro, Insulin lispro protamine suspension

Rapid-acting insulin, Intermediate-acting insulin.

injection

The following are the uses of Insulin lispro, Insulin lispro protamine suspension Injection:

• Used for managing blood sugar levels in type 1 and type 2 diabetes
• Used for improving blood glucose control in diabetic patients
• Used for treating high blood sugar in emergencies
• Used for adjusting insulin doses based on individual needs
• Used for providing a rapid-acting insulin option for better flexibility
• Used for preventing hyperglycemia and diabetic complications
• Used for achieving tighter glycemic control during pregnancy in diabetic mothers

In the case of an overdose of Insulin lispro or Insulin lispro protamine suspension, the primary concern is hypoglycemia. Symptoms may include tremors, sweating, confusion, and loss of consciousness. Immediate treatment involves administering fast-acting glucose orally or, if unconscious, intravenous glucose. Close monitoring of blood glucose levels is necessary, and medical professionals should be contacted for further management to prevent complications.

In the case of a missed dose of Insulin lispro, it is recommended to inject the missed dose as soon as you remember, but if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Insulin lispro protamine suspension, if you miss a dose, administer it as soon as possible, but if it's close to the time for the next dose, you may skip the missed dose and resume your regular dosing schedule. Always monitor your blood sugar levels and consult your healthcare provider if you have concerns.

To administer Insulin lispro and Insulin lispro protamine suspension injection, inject the prescribed dose subcutaneously, preferably into the abdomen, thigh, or upper arm, and rotate injection sites to ensure optimal absorption, following the dosage instructions provided by your healthcare professional.

Following are the conditions/situations when Insulin lispro and Insulin lispro protamine suspension Injection should not be used:

• Not recommended for individuals with known hypersensitivity or severe allergic reactions to insulin lispro or any of its excipients.
• Should not be used in patients with diabetic ketoacidosis.
• Contraindicated in patients with hypersensitivity or severe allergic reactions to protamine.
• Not suitable for individuals with impaired liver or kidney function.
• Should not be used during episodes of hypoglycemia (low blood sugar).
• Not recommended for patients with a history of severe hypoglycemic reactions.

The side effects of Insulin lispro, Insulin lispro protamine suspension Injection may include:

• Low blood sugar (hypoglycemia)
• Injection site reactions (such as redness, swelling, or itching)
• Skin reactions, including itching, rash, or hives
• Weight gain
• Cough or shortness of breath
• Swelling of the limbs (peripheral edema)
• Allergic reactions, including anaphylaxis (rare)
• Blurred vision or changes in vision

Following are the precautions and warnings for Insulin lispro and Insulin lispro protamine suspension Injection:

• Do not share your injection pen or syringe with another person, even if the needle is changed, due to the risk of transmitting infections.
• This medication should be used with caution in individuals with kidney or liver disease, as dosage adjustments may be necessary.
• Hypoglycemia (low blood sugar) is a possible side effect, so regular monitoring of blood glucose levels is crucial. Always keep a source of glucose available to treat low blood sugar.
• Avoid driving or operating heavy machinery if you experience dizziness or drowsiness after taking this medication.
• Insulin requirements may change during illness, stress, or unusual physical activity; consult your healthcare provider for adjustments.
• Inform your doctor about all medications you are taking, as certain drugs can affect blood sugar levels.
• Not recommended for use in children without medical supervision.
• Pregnant and breastfeeding women should consult their healthcare professional for advice before using this medication.

Following are the drug interactions for Insulin Lispro and Insulin Lispro Protamine Suspension Injection:

• Beta-blockers (e.g., propranolol) may mask the symptoms of hypoglycemia, such as tachycardia, making it harder to recognize low blood sugar levels.
• Corticosteroids (e.g., prednisone) and thiazide diuretics (e.g., hydrochlorothiazide) may increase blood sugar levels, potentially requiring an adjustment in insulin dose.
• Alcohol can increase the risk of hypoglycemia or cause delayed hypoglycemia, especially when consumed in excess.
• Oral contraceptives may increase blood glucose levels, possibly requiring dose adjustments in insulin therapy.
• ACE inhibitors (e.g., enalapril) may enhance insulin sensitivity and lower blood glucose levels, increasing the risk of hypoglycemia.
• Antithyroid medications (e.g., propylthiouracil) may enhance the effects of insulin, increasing the risk of hypoglycemia.
• Monoamine oxidase inhibitors (MAOIs) may increase insulin sensitivity and the risk of hypoglycemia.
• SGLT-2 inhibitors (e.g., empagliflozin, canagliflozin) can lead to an increased risk of diabetic ketoacidosis when used with insulin therapy.
• Beta-agonists (e.g., albuterol) used for asthma or COPD can increase blood glucose levels, potentially necessitating insulin dose adjustments.
• Somatostatin analogs (e.g., octreotide) may interfere with insulin action and potentially cause fluctuations in blood glucose levels.
• Fluoroquinolones (e.g., ciprofloxacin, levofloxacin) may both increase or decrease blood glucose levels, requiring close monitoring and potential insulin dose adjustments.

Following are the food interactions for Insulin lispro, Insulin lispro protamine suspension Injection:

• This medication can be administered without regard to meals, but it's important to maintain a consistent carbohydrate intake to ensure stable blood sugar levels.
• Avoid excessive alcohol consumption as it can interfere with blood sugar control and increase the risk of hypoglycemia or hyperglycemia.
• There is no direct food interaction with Insulin lispro, but it's crucial to monitor carbohydrate intake and adjust insulin doses accordingly.
• Carbohydrate counting and portion control are essential to effectively manage blood glucose levels.
• Avoid rapid changes in diet, especially during intensive insulin therapy, as it can affect blood sugar control.
• High-fat meals may delay the absorption of insulin, so monitor blood glucose levels closely after such meals.
• Always follow the dietary plan provided by your healthcare professional to ensure optimal insulin therapy.

Insulin lispro and Insulin lispro protamine suspension injections require proper storage and disposal to maintain their effectiveness and ensure safety. Store the injections in a refrigerator at a temperature between 2°C and 8°C (36°F and 46°F), protecting them from freezing. It is crucial to keep the medication in its original container, tightly sealed, and away from direct sunlight and moisture. Avoid exposure to extreme temperatures, including heat sources like stoves or radiators, as it can impact the medication's quality. Dispose of any unused or expired injections through appropriate medical waste channels; do not throw them in the trash or pour them down the drain. Consult your pharmacist or healthcare provider for specific guidance on proper disposal methods in your area. Keep the medication securely stored, out of children's reach, to prevent accidental exposure.

Following are the quick tips for Insulin lispro and Insulin lispro protamine suspension Injection:

• Always check the insulin type and strength on the label before each injection to avoid medication errors.
• Rotate injection sites as instructed to prevent lipodystrophy and skin changes.
• Do not dilute or mix with other insulins unless advised by your healthcare provider.
• Dispose of used needles and syringes safely in a puncture-proof container.
• Store unopened insulin vials/cartridges in the refrigerator. Do not freeze.
• Once opened, store insulin as directed, and do not use beyond the recommended time frame.
• Report any changes in skin appearance, severe hypoglycemia, or allergic reactions to your doctor immediately.