HYALGAN INJ

Sodium hyaluronate injection, a synthetic form of hyaluronic acid, mimics the natural lubricating and shock-absorbing properties of synovial fluid in joints. Its mechanism of action primarily involves viscosupplementation, where the highly viscous nature of sodium hyaluronate enhances the elasticity and viscosity of the synovial fluid. When injected into the joint space, it supplements the natural synovial fluid, reducing friction between articular cartilage and providing a protective cushion. This action helps alleviate joint pain, improves joint mobility, and promotes overall joint health by reducing inflammation and preventing further cartilage degradation.

Viscosupplementation agent

Injection

The following are the uses of Sodium Hyaluronate Injection:

• Used for improving skin hydration and elasticity, reducing the appearance of fine lines and wrinkles.
• Used for treating joint pain and improving mobility, particularly in osteoarthritis patients.
• Used for eye surgeries and as a lubricant to protect and maintain eye moisture.
• Used for wound healing and scar reduction, promoting tissue regeneration.
• Used for treating dry mouth and providing oral moisture relief.
• Used for maintaining cardiovascular health by supporting blood vessel integrity.
• Used for certain dental procedures to aid in tissue repair and healing.
• Used for hair care, enhancing scalp health and promoting hair growth.

In the case of an overdose of Sodium Hyaluronate Injection, individuals may experience localized pain, swelling, and redness at the injection site. Systemic symptoms could include fever, chills, and allergic reactions such as itching, hives, or difficulty breathing. Prompt medical intervention is necessary to manage these symptoms effectively. Treatment may involve monitoring vital signs, providing supportive care, and administering appropriate medications to address any adverse reactions.

In the case of a missed dose of Sodium Hyaluronate Injection, it is important to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for the missed one, as this may increase the risk of side effects. It is advisable to set reminders or use a medication tracker to help ensure that doses are not missed in the future. Consult your healthcare provider if you frequently miss doses or have concerns about the timing of your injections.

To administer Sodium Hyaluronate Injection, ensure the solution is at room temperature, clean the injection site with an alcohol swab, and carefully inject the prescribed dose subcutaneously or intramuscularly, following the instructions provided by your healthcare professional or the package insert for proper administration technique and dosage guidelines.

Following are the conditions when Sodium Hyaluronate Injection should not be administered:

• Allergic reactions • Should not be used if the patient has a known history of allergic reactions to Sodium Hyaluronate or any other ingredients in the injection.
• Skin infections • Contraindicated in areas of skin with active infections, open wounds, or severe skin diseases.
• Uncontrolled diabetes • Not recommended for patients with poorly controlled diabetes as it may affect wound healing.
• Bleeding disorders • Should be avoided in patients with bleeding disorders or those taking anticoagulants, as it may increase the risk of bleeding at the injection site.
• Implanted devices • Not suitable for use over or near implanted devices, such as pacemakers or defibrillators.
• Pregnant or breastfeeding • Sodium Hyaluronate injections are generally not recommended during pregnancy and breastfeeding, unless the potential benefits outweigh the risks.
• Joint infections • Should not be injected into joints that are infected or suspected of being infected.
• Joint damage • Contraindicated in joints with severe damage or instability, as it may not provide sufficient support.

The side effects of Sodium Hyaluronate Injection may include:

• Redness, swelling, or pain at the injection site
• Bruising
• Itching or rash
• Joint stiffness or discomfort
• Headache
• Mild fever
• Temporary increased sensitivity at the treated joint
• Allergic reactions (rare)

Following are the precautions and warnings for Sodium Hyaluronate Injection:

• Not recommended for patients with a known hypersensitivity or allergy to Sodium Hyaluronate or any of its excipients.
• Avoid injecting into areas with active skin infections or open wounds.
• Ensure proper aseptic techniques are followed to minimize the risk of infection.
• Caution is advised in patients with a history of autoimmune diseases or bleeding disorders, as it may affect the treatment outcome.
• Do not inject into blood vessels or muscles; it is intended for intra-articular or soft tissue use only.
• Not recommended for use in pregnant or breastfeeding women unless the potential benefits outweigh the risks.
• Patients with a history of multiple joint pain or inflammation should be monitored closely for any adverse reactions.

Following are the drug interactions for Sodium Hyaluronate Injection:

• Concurrent use with corticosteroids or NSAIDs may increase the risk of joint damage and should be avoided.
• Avoid using local anesthetics with epinephrine as it can cause vasoconstriction and reduce the effectiveness of Sodium Hyaluronate.
• The injection should not be mixed with other medications in the same syringe, especially with corticosteroids or local anesthetics.
• Hyaluronidase enzyme, if used, should be administered separately, as it can degrade Sodium Hyaluronate.
• Drugs affecting blood viscosity, such as anticoagulants, may influence the distribution and effectiveness of the injection.
• The use of Sodium Hyaluronate with other intra-articular products is not recommended due to potential interference with product characteristics.
• Consult a healthcare professional before using any other medications, especially those affecting joint health or blood circulation.

Following are the food interactions to consider with Sodium Hyaluronate Injection:

• Avoid excessive salt (sodium chloride) intake in your diet, as it may counteract the effects of Sodium Hyaluronate and potentially lead to fluid retention.
• Limit your consumption of processed and high-sodium foods like fast food, chips, and canned soups, as these can interfere with the treatment.
• Stay hydrated by drinking plenty of water to support the hydrating effects of the injection.
• Maintain a balanced diet rich in antioxidants, such as colorful fruits and vegetables, to promote overall joint health.
• Consider incorporating foods with natural anti-inflammatory properties, such as fatty fish (rich in omega-3), turmeric, and ginger, to complement the injection's effects.
• Avoid excessive caffeine intake, as it can potentially dehydrate the body, which may impact the efficacy of the treatment.
• There are no specific food restrictions with Sodium Hyaluronate Injection, but a healthy diet is generally recommended to support overall well-being during the treatment.

Sodium Hyaluronate Injection should be stored in a controlled environment, preferably between 2°C and 25°C (36°F and 77°F), in its original packaging to maintain sterility. Protect it from direct sunlight, extreme temperatures, and moisture to ensure its stability and effectiveness. Always check the expiration date before use and discard any expired or unused vials according to local regulations and guidelines. Proper disposal methods are crucial to prevent environmental contamination; do not dispose of the injection by flushing or pouring it down the drain. Consult healthcare professionals or pharmacists for specific instructions on safe disposal practices in your area, ensuring compliance with local regulations. Keep the injection out of children's reach to prevent accidental exposure.

Following are the quick tips for Sodium Hyaluronate Injection:

• Ensure the injection is administered by a trained healthcare professional.
• Verify the injection site is clean and disinfected before administration.
• Gently massage the area after injection to help reduce discomfort.
• Stay hydrated before and after the procedure to support overall health.
• Avoid strenuous activities immediately after the injection for better recovery.
• Report any unusual pain, swelling, or redness at the injection site to your doctor promptly.
• Regularly follow-up with your healthcare provider to monitor treatment progress.
• Inform your doctor about any medications or supplements you are taking.