Hydralazine HCl (20mg/ml) 1 Ampoule Injection

Hydralazine HCl acts as a direct-acting smooth muscle relaxant, primarily targeting vascular smooth muscle cells. It exerts its main effect by inhibiting the binding of calcium ions to troponin C in smooth muscle, which prevents the activation of actin-myosin cross-bridges and leads to smooth muscle relaxation. This mechanism results in peripheral vasodilation, particularly of arterioles, leading to a decrease in blood pressure. Hydralazine also has a weak direct effect on cardiac muscle, causing a reduction in peripheral vascular resistance and afterload, which can lead to an increase in heart rate and stroke volume.

HYDRALAZINE HCl

Antihypertensive

Injection

The following are the uses of HYDRALAZINE HCl Injection:

• Used for treating severe hypertension when rapid reduction of blood pressure is required.
• Used for managing hypertensive emergencies, such as hypertensive crisis or eclampsia.
• Used for improving blood flow in conditions like Raynaud's phenomenon.
• Used for preventing and treating chronic heart failure in combination with other medications.
• Used for managing hypertension in pregnancy, under strict medical supervision.
• Used for reducing high blood pressure before and during surgeries.
• Used for preventing and treating pulmonary hypertension.

In the case of an overdose of HYDRALAZINE HCl Injection, immediate medical intervention is necessary. Symptoms may include severe hypotension, bradycardia, and even cardiovascular collapse. Treatment should focus on managing these symptoms, possibly including intravenous fluids, vasopressors, and cardiac monitoring. Prompt medical care is vital to prevent potential complications and ensure the patient's well-being.

In the case of a missed dose of HYDRALAZINE HCl Injection, it is important to administer the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or asking someone to help you stay on track with your medication routine. Consult your healthcare provider if you have any concerns or questions about managing missed doses.

To administer HYDRALAZINE HCl Injection, prepare the injection by drawing the prescribed dose into a syringe, then inject it into a muscle or under the skin, following the instructions provided by your healthcare professional.

Following are the conditions/situations when HYDRALAZINE HCl Injection should not be used:

• Must not be used in patients with a known allergy or hypersensitivity to hydralazine or any of the excipients in the injection.
• Contraindicated in patients with coronary artery disease, especially those with severe or unstable angina.
• Should not be used in patients with mitral valvular rheumatism.
• Not recommended for individuals with liver cirrhosis or severe liver impairment.
• Should be avoided in patients with chronic kidney disease or renal failure.
• Not suitable for patients with a history of lupus-like syndrome or drug-induced lupus.
• Must be used with caution and avoided if possible in patients with severe heart failure or cardiogenic shock.
• Contraindicated during the second trimester of pregnancy due to potential fetal risks.

The side effects of HYDRALAZINE HCl Injection may include:

• Headache
• Dizziness
• Nausea and vomiting
• Palpitations or rapid heartbeat
• Chest pain
• Skin rashes or itching
• Diarrhea
• Muscle and joint pain

Following are the precautions and warnings for HYDRALAZINE HCl Injection:

• Allergic reactions may occur; patients with a known hypersensitivity to hydralazine or related compounds should not use this medication.
• Blood pressure should be monitored regularly, especially during initial dosage adjustments and with concomitant medications.
• Hydralazine may cause a reflex tachycardia, so caution is advised in patients with ischemic heart disease or impaired coronary artery reserve.
• It can cause a lupus-like syndrome; patients should be monitored for symptoms such as arthralgia, fever, and skin rash.
• This medication may cause headaches, dizziness, and fatigue; patients should avoid situations where alertness is crucial.
• HYDRALAZINE HCl Injection should be used with caution in patients with impaired liver or kidney function as it is primarily metabolized in the liver and excreted by the kidneys.
• The use of this medication during pregnancy and breastfeeding should be under medical supervision as it may have potential risks to the fetus or infant.

Following are the drug interactions for HYDRALAZINE HCl Injection:

• Beta-blockers may reduce the antihypertensive effect of hydralazine, so careful monitoring of blood pressure is required.
• The combination with nitrates can lead to severe hypotension and should be used cautiously, especially in patients with coronary artery disease.
• Diuretics, when used with hydralazine, may increase the risk of orthostatic hypotension.
• Hydralazine can enhance the effects of other antihypertensive drugs, requiring dose adjustments.
• Tricyclic antidepressants and hydralazine may cause a sudden drop in blood pressure.
• Alcohol consumption can intensify the hypotensive effects of HYDRALAZINE HCl.
• The use of calcium channel blockers alongside hydralazine may result in excessive blood pressure reduction.
• Certain medications metabolized by the liver may have increased blood levels when taken with hydralazine.

Following are the food interactions to be aware of when taking HYDRALAZINE HCl Injection:

• Avoid excessive consumption of salt or foods high in sodium content. This medication may cause sodium retention, and high sodium intake can reduce its effectiveness.
• Limit alcohol intake as it may increase the risk of low blood pressure and dizziness, especially when starting the medication.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of some medications, although there is limited information regarding its interaction with HYDRALAZINE.
• Avoid tyramine-rich foods like aged cheeses, cured meats, and certain types of beer. Tyramine can increase blood pressure and interact with the medication's effects.
• Caffeine-rich foods and beverages like coffee, tea, and chocolate should be consumed in moderation as they may influence blood pressure.
• A balanced diet with adequate potassium and magnesium is recommended. These minerals support cardiovascular health and may help manage blood pressure.
• Avoid licorice or licorice-containing products as they can affect blood pressure and potentially interact with the medication.

Hydralazine HCl Injection should be stored and disposed of with utmost care. It should be kept in a secure, designated area, protected from light and moisture, and stored at room temperature, typically between 68°F and 77°F (20°C and 25°C). Ensure the injection is stored in its original packaging, tightly sealed, to maintain sterility and prevent contamination. Do not freeze the injection as it may affect its potency. When disposing of unused or expired Hydralazine HCl Injection, do not flush it down the toilet or pour it down the drain. Contact your healthcare provider or pharmacist for instructions on proper disposal methods to ensure environmental safety. Keep the medication out of children's reach to prevent accidental exposure.

Following are the quick tips for HYDRALAZINE HCl Injection:

• Administer the injection under medical supervision for proper dosage and administration.
• Ensure the injection is clear and free from particles before use.
• Use a sterile syringe and needle for each injection to prevent contamination.
• Inject the solution slowly into the vein as directed by your healthcare professional.
• Rotate injection sites to minimize skin irritation and discomfort.
• Dispose of used needles and syringes safely in a puncture-proof container.
• Store the injection as directed on the packaging, away from direct sunlight and moisture.