Hydrim Syrup

Diphenhydramine is a first-generation ethanolamine-derivative antihistamine that exhibits a range of effects, primarily through its strong antagonism of the histamine H1 receptor. By blocking H1 receptors, diphenhydramine inhibits the histamine-induced H1 receptor activation that would otherwise result in increased vascular permeability, leading to a reduction in the symptoms associated with allergic reactions. Additionally, diphenhydramine's interaction with muscarinic acetylcholine receptors contributes to its sedative and anticholinergic effects, including drowsiness, reduced coordination, and relief from motion sickness. This multifaceted mechanism of action makes diphenhydramine a versatile medication for managing allergies, insomnia, and various other conditions.

Antihistamine

Suspension

The following are the uses of Diphenhydramine Syrup/Suspension:

• Used for relieving symptoms of allergies such as sneezing, runny nose, and itching.
• Used for treating allergic reactions and reducing associated itching and swelling.
• Used to help with cough suppression, especially in cases of allergy-induced coughs.
• Used for managing motion sickness and preventing nausea and vomiting.
• Used for inducing sleep and treating insomnia due to its sedative effects.
• Used for providing short-term relief from occasional anxiety and nervousness.
• Used as a sleep aid for patients undergoing medical procedures or surgeries.

Follow these dosage instructions:

• Adult Dosage

For adults (above 18), 1-2 teaspoons of Hydryllin DM 120ml 2-3 times a day or prescribed by the doctor.

• Child Dosage

For children (below 17), 1 teaspoon of Hydryllin DM 120ml 2 times a day.

In the case of an overdose of Diphenhydramine Syrup/Suspension, several symptoms may occur, including severe drowsiness, confusion, rapid heartbeat, and even hallucinations. Immediate medical attention is required as an overdose can lead to serious health complications. Prompt action should be taken, such as contacting a poison control center or seeking emergency medical care to mitigate the potential risks associated with excessive consumption of this medication.

In the case of a missed dose of Diphenhydramine Syrup/Suspension, it is important to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume the medication. It is recommended to establish a routine to help prevent missed doses in the future.

To take Diphenhydramine Syrup/Suspension, shake the bottle well, measure the prescribed dose with a measuring device, and administer it orally, following the dosage instructions provided by your healthcare professional, typically taken every 4 to 6 hours, without exceeding the maximum daily dosage as directed.

Following are the conditions/situations when Diphenhydramine Syrup/Suspension should not be used:

• Should not be administered to infants or young children without medical advice.
• Contraindicated in individuals with a known allergy or hypersensitivity to Diphenhydramine or other similar antihistamines.
• Not recommended for patients with narrow-angle glaucoma.
• Avoid use in individuals with asthma, chronic pulmonary disease, or chronic bronchitis.
• Should not be used in patients with a history of seizures or epilepsy.
• Contraindicated in patients with prostate enlargement or urinary retention issues.
• Avoid use in individuals with heart disease, high blood pressure, or cardiovascular disorders.
• Not suitable for those with severe liver or kidney disease.
• Should not be combined with other sedatives or central nervous system depressants without medical supervision.
• Avoid use in patients with a history of stomach ulcers or obstructions in the gastrointestinal tract.

The side effects of Diphenhydramine Syrup/Suspension may include:

• Drowsiness or sedation
• Dry mouth and throat
• Blurred vision
• Constipation
• Dizziness or vertigo
• Nausea and vomiting
• Confusion, especially in elderly individuals
• Increased heart rate or palpitations

Following are the precautions and warnings for Diphenhydramine Syrup/Suspension:

• Not recommended for individuals with a known allergy to diphenhydramine or similar antihistamines.
• This medication can cause drowsiness and dizziness; avoid driving, operating heavy machinery, or engaging in activities that require alertness until you know how it affects you.
• Alcohol consumption should be avoided as it may enhance the sedative effects of the medication.
• Patients with a history of respiratory problems, asthma, glaucoma, or difficulty urinating should use with caution and consult a healthcare professional.
• Not suitable for patients with a history of liver or kidney disease without medical advice.
• May cause excitability, especially in children, and may lead to increased heart rate and blood pressure.
• Pregnant and breastfeeding women should consult a healthcare provider before use, as it may affect the fetus or pass into breast milk.

Following are the drug interactions for Diphenhydramine Syrup/Suspension:

• Alcohol or other central nervous system (CNS) depressants can increase sedation and respiratory depression when combined with Diphenhydramine.
• It may reduce the effectiveness of anticholinesterase agents like pyridostigmine used in myasthenia gravis.
• Antihistamines can decrease the absorption of certain antibiotics like tetracyclines and penicillins.
• Diphenhydramine can potentiate the effects of other anticholinergic drugs, including tricyclic antidepressants and antipsychotics.
• When taken with monoamine oxidase inhibitors (MAOIs), it can lead to increased anticholinergic and CNS effects.
• Antihypertensive medications may have their effects reduced due to the alpha-adrenergic blocking action of Diphenhydramine.
• It may also interact with certain medications used for Parkinson's disease, as it can block the action of dopamine.

Following are the food interactions for Diphenhydramine Syrup/Suspension:

• Alcohol consumption should be avoided as it can increase the sedative effects of Diphenhydramine, leading to enhanced drowsiness and impaired motor skills.
• Grapefruit and grapefruit juice are known to interact with Diphenhydramine, potentially increasing its levels in the blood. This interaction may lead to more pronounced side effects.
• Dairy products, especially milk, can reduce the absorption of Diphenhydramine, possibly reducing its effectiveness. Consider taking the medication at least 1-2 hours before or after consuming dairy.
• Caffeine and other stimulants should be limited as Diphenhydrapmine can already cause stimulation, and combining it with caffeine might lead to overstimulation, anxiety, and sleep disturbances.
• Avoid heavy or high-fat meals as they may delay the absorption of Diphenhydramine, potentially affecting the onset of its action.
• Consuming the medication with a light snack or meal can help reduce the likelihood of an upset stomach, a common side effect of Diphenhydramine.
• Always ensure you are well-hydrated when taking this medication to avoid dehydration-related side effects.
• Certain citrus fruits like oranges or tangerines may slightly alter the pH of the stomach, potentially affecting the absorption of Diphenhydramine.

Diphenhydramine Syrup/Suspension should be stored in a secure location, preferably in a locked medicine cabinet, at room temperature, ensuring it is kept away from excessive heat, direct sunlight, and moisture. It is crucial to store this medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. Always verify the expiration date, and if the syrup is no longer needed or has expired, do not dispose of it by flushing or pouring it down the drain. Instead, consult your local pharmacist or healthcare provider for guidance on safe disposal methods to protect the environment. Keep the medication away from children to prevent accidental consumption.

No

Following are the quick tips for Diphenhydramine Syrup/Suspension:

• Consult a healthcare professional before use, especially for children under 6 years old.
• Measure the dose accurately using the provided measuring device.
• Avoid alcohol consumption while taking this medication to prevent increased drowsiness.
• Do not drive or operate machinery until you know how this medication affects you.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Inform your doctor about any other medications you're taking to avoid potential interactions.
• Contact a healthcare provider if symptoms persist or worsen after taking the syrup.