Hydro Sod.Suc. (250mg) 1 Vial Injection

Hydrocortisone Sodium Succinate is a synthetic corticosteroid that exerts its therapeutic effects primarily through its anti-inflammatory and immunosuppressive actions. When administered, it rapidly enters the bloodstream and binds to intracellular glucocorticoid receptors, initiating a cascade of events. The primary mechanism involves inhibiting the production and release of pro-inflammatory mediators, such as prostaglandins and leukotrienes, by suppressing the activity of inflammatory cells and downregulating the expression of inflammatory genes. It also stabilizes lysosomal membranes, reducing the release of enzymes that contribute to tissue damage. Additionally, Hydrocortisone Sodium Succinate modulates the immune response by suppressing T-cell activation, reducing antibody production, and inhibiting the migration of inflammatory cells to sites of inflammation. This multifaceted mechanism of action helps to alleviate symptoms and control the underlying pathophysiological processes in various inflammatory and autoimmune conditions.

Hydrocortisone Sodium Succinate 250mg

Glucocorticoid, Corticosteroid.

injection

The following are the uses of Hydrocortisone Sodium Succinate 250mg injection:

• Used for treating severe allergic reactions and asthma attacks.
• Used to manage inflammation in conditions like inflammatory bowel disease.
• Used for suppressing the immune system during organ transplants.
• Used to combat shock and low blood pressure in critical care.
• Used for treating Addison's disease and adrenal insufficiency.
• Used for managing certain types of arthritis and joint inflammation.
• Used for reducing brain swelling in some neurological conditions.
• Used as a supplement for adrenal gland disorders.

Follow these dosage instructions:

• Child 12 years and over and adult

• Child one month to 11 years

In the case of an overdose of Hydrocortisone Sodium Succinate 250mg injection, prompt medical attention is necessary. Symptoms may include rapid weight gain, swelling, and increased blood pressure. The severity of the overdose can vary, and immediate treatment should be sought. Medical professionals will assess the patient's condition and may administer supportive care to manage symptoms and ensure the patient's well-being. It is crucial to seek help quickly to prevent potential complications.

In the case of a missed dose of Hydrocortisone Sodium Succinate 250mg injection, it is important to administer the missed dose as soon as possible. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you have missed multiple doses, contact your healthcare provider for guidance on how to safely resume your medication.

To administer Hydrocortisone Sodium Succinate 250mg injection, reconstitute the powder with the provided sterile diluent, gently swirl to dissolve, and then inject the solution slowly into a muscle or vein as directed by your healthcare professional, ensuring proper aseptic technique and following the prescribed dosage instructions.

Here are the conditions and situations when Hydrocortisone Sodium Succinate 250mg injection should not be administered:

• Must not be used in patients with a known allergy to Hydrocortisone, any corticosteroids, or any of the injection's components.
• Not suitable for individuals with systemic fungal infections unless it is for the treatment of Cushing's syndrome.
• Contraindicated in patients with widespread bacterial infections unless specific anti-infective therapy is also being given.
• Should be avoided in patients with recent intestinal or urinary tract anastomoses, as it may increase the risk of leakage.
• Not recommended for patients with active tuberculosis.
• Should not be used in patients with idiopathic thrombocytopenic purpura (ITP).
• Avoid use in patients with myasthenia gravis, as it may exacerbate muscle weakness.
• Not suitable for patients with recent heart attack or severe heart failure.
• Contraindicated in patients with herpes simplex keratitis, as it may cause corneal perforation.
• Should not be used to treat patients with viral infections (such as chickenpox or measles) unless it is to control life-threatening reactions.

The side effects of Hydrocortisone Sodium Succinate 250mg injection may include:

• Increased appetite and weight gain
• Mood changes, including feeling anxious or depressed
• Sleep disturbances
• Muscle weakness or muscle wasting
• Easy bruising or thinning of the skin
• Slow wound healing
• Elevated blood sugar levels (hyperglycemia)
• Electrolyte imbalances

Following are the precautions and warnings for Hydrocortisone Sodium Succinate 250mg injection:

• This medication is for intravenous or intramuscular use only and should be administered by trained medical professionals.
• Patients with existing infections should be closely monitored as hydrocortisone can mask the signs of infection.
• Caution is advised in patients with a history of heart disease, as it may cause fluid retention and increased blood pressure.
• Diabetic patients should be aware that hydrocortisone can elevate blood sugar levels.
• Prolonged use may lead to muscle wasting, osteoporosis, and increased risk of fractures, especially in elderly patients.
• Patients should be regularly monitored for signs of adrenal suppression, particularly when transitioning from long-term use.
• Individuals with a history of hypersensitivity reactions to hydrocortisone or any of its excipients should avoid this medication.

Following are the drug interactions for Hydrocortisone Sodium Succinate 250mg injection:

• Concurrent use with live vaccines is not recommended as Hydrocortisone can suppress the immune response, reducing vaccine effectiveness.
• May decrease the therapeutic effects of anticoagulants like warfarin, requiring closer monitoring of coagulation parameters.
• Hydrocortisone can increase the risk of gastrointestinal bleeding when used with nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or aspirin.
• Anticonvulsant levels may be reduced by Hydrocortisone, potentially decreasing their effectiveness.
• Can increase blood glucose levels, requiring dosage adjustments of antidiabetic medications.
• The metabolism of Hydrocortisone can be affected by drugs that induce or inhibit liver enzymes, leading to altered drug effects.
• Use with other immunosuppressants may increase the risk of infection and other side effects.

Following are the food interactions for Hydrocortisone Sodium Succinate 250mg injection:

• Avoid excessive salt or sodium intake, as this medication can cause sodium retention, leading to increased blood pressure and fluid retention.
• Alcohol consumption should be limited as it may increase the risk of gastrointestinal issues and delay healing.
• Patients with diabetes should carefully monitor their blood sugar levels, as this medication can increase blood glucose levels.
• Avoid high-potassium foods like bananas, oranges, and tomatoes, as this drug may cause potassium retention.
• Avoid grapefruit and grapefruit juice, as they can affect the metabolism of the drug and increase its levels in the body.
• Maintain a balanced diet to support overall health and healing during treatment.
• Consult a healthcare professional for personalized dietary advice, especially if you have specific medical conditions.

Hydrocortisone Sodium Succinate 250mg injection should be stored and disposed of with utmost care. It is recommended to keep the injection in a cool, dry place, preferably at room temperature, ensuring it is protected from light and moisture. The original packaging should be tightly sealed to maintain its integrity and prevent contamination. Avoid extreme temperatures, such as those near heat sources or in bathrooms, as they can impact the medication's effectiveness. Always adhere to the expiration date, and when disposing of any unused or expired injections, do not flush or pour them into drains. Instead, consult a pharmacist or healthcare professional for safe disposal methods, and keep the medication away from children to prevent accidental exposure.

No

Following are the quick tips for Hydrocortisone Sodium Succinate 250mg injection:

• Ensure the injection is administered by a trained healthcare professional.
• Confirm your medical history and current medications to avoid interactions.
• Inform your doctor about allergies to avoid adverse reactions.
• Store the injection as directed, away from light and moisture.
• Do not reuse needles or syringes; dispose of them safely.
• Seek immediate medical attention if you experience severe side effects.
• Regularly monitor your health and report any unusual symptoms to your doctor.
• Stay hydrated and follow any dietary recommendations provided.