HYPRHO D 300UG INJ

Rho (D) immunoglobulin (Human) Injection works by binding to and neutralizing Rh-positive red blood cells (RBCs) that may have entered the bloodstream of an Rh-negative individual. It is specifically designed to target the D antigen present on Rh-positive RBCs. When administered, the immunoglobulin contains antibodies that recognize and attach to the Rh(D) antigen, forming immune complexes. These immune complexes are then cleared from the circulation by the body's immune system, preventing the Rh-positive RBCs from triggering an immune response in the Rh-negative individual. This mechanism helps to prevent the production of antibodies against the Rh(D) antigen, thereby averting potential complications such as hemolytic disease of the fetus and newborn (HDFN) in subsequent pregnancies.

Immune Globulin

Injection

The following are the uses of Rho (D) immunoglobulin (Human) Injection:

• Used for preventing Rh hemolytic disease in pregnant women who are Rho (D) negative
• Used for treating a dangerous immune response called immune thrombocytopenia (ITP)
• Used for treating certain blood disorders like hemolytic anemia
• Used for treating thrombocytopenia associated with HIV
• Used for treating hereditary spherocytosis, a condition affecting red blood cells
• Used for preventing isoimmunization in Rho (D) negative patients
• Used for treating certain cases of fetal-maternal hemorrhage

In the case of an overdose of Rho (D) immunoglobulin (Human) Injection, adverse effects may be observed, particularly in individuals who have received excessive doses. Overdose symptoms can include fever, chills, nausea, and local injection site reactions. Medical professionals should be contacted immediately to assess the severity of the overdose and provide appropriate treatment, which may include monitoring for potential allergic reactions and managing any discomfort or side effects experienced by the patient.

In the case of a missed dose of Rho (D) immunoglobulin (Human) Injection, it is crucial to consult your healthcare provider as soon as possible. Missing a dose may reduce the effectiveness of the treatment, especially if it is a scheduled dose for postpartum or post-abortion administration. Your healthcare provider will guide you on the appropriate course of action, which may involve rescheduling the dose or adjusting the treatment plan to ensure optimal protection against Rh sensitization.

To administer Rho (D) immunoglobulin (Human) Injection, follow the instructions provided by your healthcare professional. Cleanse the injection site with an alcohol wipe, insert the needle at a 90-degree angle, and slowly inject the prescribed dose subcutaneously, ensuring the entire dose is delivered.

Following are the conditions/situations when Rho (D) Immunoglobulin (Human) Injection should not be administered:

• Not recommended for individuals with a history of severe allergic reactions to human immune globulin products.
• Contraindicated in individuals with anaphylactic or severe systemic reactions to previous Rho(D) immune globulin administration.
• Should not be used in individuals with severe child-P or hexose utilization glycoprotein (HUG) antibody systems.
• Not suitable for individuals with a history of severe thrombocytopenia or anemia after Rho(D) immune globulin administration.
• Avoid in individuals with a history of IgA deficiency, as they may have antibodies against IgA.
• Not recommended for individuals with severe bleeding disorders or those on anticoagulant therapy.
• Should not be administered to individuals with a history of severe or life-threatening autoimmune diseases.

The side effects of Rho (D) immunoglobulin (Human) Injection may include:

• Mild fever or chills.
• Headache or dizziness.
• Nausea or vomiting.
• Pain, redness, or swelling at the injection site.
• Fatigue or weakness.
• Joint or muscle pain.
• Skin rash or itching.
• Increased heart rate or blood pressure changes.

Here are the precautions and warnings for Rho (D) immunoglobulin (Human) Injection:

• Do not administer to patients with a history of hypersensitivity or severe allergic reactions to human immune globulin products or any of its components.
• Not intended for intravascular administration; must be given intramuscularly or intravenously as directed.
• Patients should be monitored for potential volume overload, especially in individuals with cardiovascular or renal conditions.
• Rho (D) immunoglobulin should be used with caution in patients with a history of thrombosis or thromboembolic disorders.
• Discontinue use and seek medical attention if symptoms of anaphylaxis or severe allergic reactions occur.
• Consult a healthcare professional if you are pregnant, breastfeeding, or planning a pregnancy before receiving this injection.
• Keep a record of the injection site and inform your healthcare provider if you experience any unusual reactions or severe pain at the injection site.

Following are the drug interactions for Rho (D) immunoglobulin (Human) Injection:

• Concomitant use with live vaccines, such as measles, mumps, rubella, or varicella, may reduce the effectiveness of the vaccine. It is recommended to delay live vaccinations for at least 3 months after receiving Rho (D) immunoglobulin.
• Immunosuppressive drugs, such as corticosteroids or chemotherapy agents, may increase the risk of infection or reduce the immune response when used with Rho (D) immunoglobulin.
• Blood thinners, such as warfarin, may require more frequent monitoring of coagulation parameters, as the injection can affect platelet function.
• Other immunoglobulins, when administered concurrently, may increase the risk of excessive immune response or immune-related side effects.
• Rho (D) immunoglobulin may interfere with the results of certain blood tests, such as direct antiglobulin tests (DAT), which could cause false-positive results.
• Concomitant use with high-dose aspirin or other anticoagulants may increase the risk of bleeding complications, especially when administered via injection.

Following are the food interactions for Rho (D) immunoglobulin (Human) Injection:

• No specific food interactions are documented with Rho (D) immunoglobulin.
• Generally, it is safe to consume regular meals and maintain a balanced diet during and after treatment.
• Stay well-hydrated by drinking adequate fluids, especially water, to support overall health.
• Avoid excessive alcohol consumption as it may impact your immune system and overall recovery.
• There is no known interaction with caffeine, but moderation is key to maintaining a healthy diet.
• If you have specific dietary restrictions or preferences, consult your healthcare provider for personalized advice.
• Maintaining a healthy and varied diet can support your immune system and overall well-being during and after treatment.
• No specific food restrictions are necessary unless advised by your healthcare professional.

Storage and disposal of Rho (D) immunoglobulin (Human) Injection require specific attention to ensure its effectiveness and safety. Store the injection in a refrigerator at a temperature between 2°C and 8°C (36°F and 46°F), protecting it from light and moisture. Do not freeze the injection as it may affect its potency. Always check the expiration date before use and discard if the solution appears discolored or contains particles. Proper disposal is crucial; do not dispose of in regular household trash or flush down the toilet. Contact your healthcare provider or pharmacist for guidance on safe disposal methods to prevent harm to the environment. Keep this medication out of the reach of children to prevent accidental exposure.

Following are the quick tips for Rho (D) immunoglobulin (Human) Injection:

• Consult a healthcare professional for personalized advice and prescription.
• Administer the injection under medical supervision for safety.
• Ensure the injection is stored and handled as per the provided instructions.
• Do not self-inject; seek medical assistance for proper administration.
• Report any adverse reactions or side effects immediately to your healthcare provider.
• Maintain a record of injection dates and doses for reference.
• Keep the injection out of reach of children and pets.
• Dispose of used needles and syringes safely.