Ibnate (3mg/3ml) 1 IV Injection

Ibnate (3mg/3ml) 1 IV Injection

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  • Manufacturer GENIX PHARMACEUTICALS (PVT.) LTD.
  • Generic Name

    Ibandronic Acid 3mg

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Ibandronic acid, a potent bisphosphonate, works by inhibiting osteoclast-mediated bone resorption. It selectively binds to hydroxyapatite in bone, disrupting osteoclast activity and function. This binding process leads to a reduction in bone turnover, preventing the excessive breakdown of bone tissue. The primary effect is to decrease the rate of bone resorption, resulting in a net increase in bone mineral density and overall bone strength.

  • Ingredients

    Ibandronic Acid 3mg

  • Drug Class

    Bisphosphonate.

  • Dosage Form

    injection

  • Uses

    The following are the uses of Ibandronic Acid 3mg injection:

    • Used for treating Paget's disease of bone, a condition where bones become weak and brittle.
    • Used for managing bone metastases, reducing the risk of fractures and pain in cancer patients.
    • Used for treating osteoporosis in postmenopausal women, helping to increase bone density and prevent fractures.
    • Used for preventing bone loss and maintaining bone health in patients with osteoporosis.
    • Used for slowing down bone resorption, allowing new bone formation and improving bone structure.
    • Used for improving bone strength and reducing the risk of spinal and hip fractures.
    • Used for managing hypercalcemia, a condition of high calcium levels in the blood, by regulating bone metabolism.
  • In case of Overdose

    In the case of an overdose of Ibandronic Acid 3mg injection, several symptoms may occur. These can include gastrointestinal issues like nausea, vomiting, and diarrhea, as well as more severe effects such as hypocalcemia, hypophosphatemia, and renal impairment. Prompt medical attention is required to manage these symptoms effectively. Treatment may involve supportive care, monitoring of vital signs, and addressing specific complications associated with the overdose.

  • Missed Dose

    In the case of a missed dose of Ibandronic Acid 3mg injection, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss multiple doses, consult your healthcare professional for advice on how to get back on track with your medication regimen. It is crucial to maintain consistency with this medication, so try to set reminders or use a pill organizer to help you remember to take it as prescribed.

  • How To Use

    To administer Ibandronic Acid 3mg injection, mix the powder with the provided sterile water, inject the solution subcutaneously, and follow the prescribed dosage as instructed by your healthcare provider, typically once every 3 months.

  • When Not to Use

    Here are the conditions or situations when Ibandronic Acid 3mg injection should not be used:

    • Allergic reaction Must not be administered to individuals with a known or suspected hypersensitivity or allergy to Ibandronic Acid or any of its excipients.
    • Renal impairment Contraindicated in patients with severe kidney problems or renal impairment as it can lead to an increased risk of adverse effects.
    • Hypocalcemia Should not be used if the patient has low levels of calcium in the blood (hypocalcemia) until the calcium levels are corrected.
    • Pregnancy and breastfeeding Ibandronic Acid is not recommended for pregnant or breastfeeding women due to potential risks to the fetus and infant.
  • Side Effects

    The side effects of Ibandronic Acid 3mg injection may include:

    • Bone, joint, or muscle pain
    • Fever
    • Flu-like symptoms
    • Dizziness
    • Stomach pain
    • Diarrhea
    • Constipation
    • Fatigue
  • Precautions & Warnings

    Following are the precautions and warnings:

    • Ibandronic Acid 3mg injection should not be administered to patients with known hypersensitivity or allergy to ibandronic acid or other bisphosphonates.
    • This medication is intended for intravenous use only and should be administered by trained healthcare professionals.
    • Patients with kidney problems should be closely monitored as dosage adjustments may be necessary.
    • Caution is advised for individuals with a history of low blood calcium levels (hypocalcemia) or vitamin D deficiency, as supplementation may be required.
    • Ibandronic Acid may cause kidney impairment, especially when used long-term; regular monitoring of kidney function is essential.
    • Patients should maintain proper oral hygiene and promptly report any signs of jaw-related issues, such as pain or swelling, to their healthcare provider.
    • It is important to ensure adequate hydration before and after the administration of this injection to reduce the risk of kidney-related complications.
    • Pregnant and breastfeeding women should consult their doctor before using this medication, as the risks and benefits should be carefully considered.
  • Drug Interactions

    Following are the drug interactions for Ibandronic Acid 3mg injection:

    • Co-administration with other bisphosphonates or nephrotoxic drugs may increase the risk of renal impairment.
    • Ibandronic acid can interact with antacids, calcium supplements, and some oral medications, reducing its absorption. It is recommended to maintain a gap of at least 2 hours before or after taking these medications.
    • The use of nonsteroidal anti-inflammatory drugs (NSAIDs) along with Ibandronic Acid may increase the risk of gastrointestinal side effects.
    • Thrombocytopenia can be exacerbated when used with drugs known to cause thrombocytopenia.
    • May increase risk of hypocalcemia when used with corticosteroids or diuretics.
    • Ibandronic acid may decrease the absorption of levothyroxine, so a gap of 2 hours should be maintained between their administration.
    • Concurrent use with aminoglycosides can increase the risk of ototoxicity.
  • Food Interactions

    Following are the food interactions with Ibandronic Acid 3mg injection:

    • Avoid consuming calcium-rich foods or beverages (like milk, yogurt, cheese, calcium-fortified foods) within 60 minutes before or 60 minutes after taking the injection, as calcium can interfere with the absorption of Ibandronic Acid.
    • Maintain a sufficient fluid intake, preferably water, before and after the injection to ensure proper hydration and reduce the risk of kidney-related side effects.
    • Do not consume alcohol, especially in large amounts, as it can increase the risk of gastrointestinal issues and negatively impact bone health.
    • Avoid taking antacids containing aluminum, magnesium, or calcium within 2 hours of taking the injection, as they can bind with Ibandronic Acid and reduce its effectiveness.
    • Limit the intake of foods high in vitamin C (such as citrus fruits, broccoli, tomatoes) around the time of injection, as excessive vitamin C may interfere with the medication's absorption.
    • Restrict the consumption of carbonated or soft drinks, as they can potentially decrease bone mineral density and interact with the medication's action.
    • Avoid excessive caffeine intake, as it may interfere with calcium absorption and potentially reduce the effectiveness of the medication.
  • Storage/Disposal

    Ibandronic Acid 3mg injection should be stored in a controlled environment, preferably in a cool and dry place, maintaining a temperature between 20°C and 25°C (68°F to 77°F). Protect the injection from direct sunlight and moisture to ensure its stability and effectiveness. Always keep the medication in its original packaging, securely sealed, to maintain its integrity and prevent contamination. It is crucial to dispose of any unused or expired Ibandronic Acid injection properly; do not discard it via household waste or sewage systems. Contact your healthcare provider or pharmacist for guidance on appropriate disposal methods. Remember to keep all medications out of the sight and reach of children to prevent accidental ingestion.

  • Quick Tips, if any

    Following are the quick tips for Ibandronic Acid 3mg Injection:

    • Administer the injection under medical supervision as directed by your healthcare professional.
    • Ensure proper handling and disposal of the injection as per medical guidelines.
    • Stay well-hydrated before and after the injection to support kidney function.
    • Maintain an upright posture for a few minutes after the injection to prevent dizziness.
    • Inform your doctor about any existing medical conditions or medications you're taking.
    • Avoid missing doses; if you miss one, consult your doctor for the next steps.
    • Store the injection as directed on the label, away from direct sunlight and moisture.
    • Report any unusual pain, fever, or injection site reactions to your healthcare provider promptly.

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