Imuran (50mg) 100 Tablets

Azathioprine 50mg Tablet primarily exerts its immunosuppressive effects through the inhibition of DNA synthesis. It is a prodrug that is metabolized in the body to active metabolites, mainly 6-mercaptopurine (6-MP). 6-MP interferes with DNA production by inhibiting an enzyme called purine nucleotide phosphorylase, which is crucial for the synthesis of purine nucleotides required for DNA replication. This interference leads to a reduction in the proliferation of immune cells, particularly lymphocytes, which are key players in immune responses. By suppressing the activity of these immune cells, azathioprine can effectively modulate the immune system, making it useful in the management of conditions where immune response needs to be controlled, such as autoimmune diseases and organ transplantation.

Immunosuppressant

Tablet

The following are the uses of Azathioprine 50mg Tablet:

• Used for preventing organ rejection in transplant patients, allowing the body to accept the new organ.
• Used for treating autoimmune diseases like rheumatoid arthritis, reducing inflammation and suppressing the overactive immune response.
• Used for managing inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, providing relief from symptoms and reducing inflammation in the digestive tract.
• Used for treating severe skin conditions like eczema and psoriasis, helping to control inflammation and skin cell overgrowth.
• Used for alleviating symptoms of systemic lupus erythematosus (SLE), an autoimmune disease affecting multiple organs.
• Used for managing autoimmune hepatitis, reducing liver inflammation caused by the body's immune system.
• Used for controlling certain blood disorders, such as autoimmune hemolytic anemia, where the immune system attacks red blood cells.
• Used for maintaining remission in various autoimmune conditions, ensuring the disease remains under control and preventing flare-ups.

In the case of an overdose of Azathioprine 50mg Tablets, individuals may experience severe side effects, including bone marrow suppression, increased risk of infections, and potential liver damage. Symptoms of overdose can include nausea, vomiting, diarrhea, and a decrease in white blood cell count, leading to a weakened immune system. Prompt medical intervention is necessary to manage the symptoms and prevent long-term complications. It is crucial to seek medical advice if an overdose is suspected, as early treatment can mitigate the risks associated with excessive Azathioprine consumption.

In the case of a missed dose of Azathioprine 50mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for advice, as they may recommend adjusting your dosing schedule or provide specific instructions to ensure you receive the correct amount of medication.

To take Azathioprine 50mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions or situations when Azathioprine 50mg Tablet should not be taken:

• Do not take if you are allergic to azathioprine or any other similar medications.
• Avoid if you have an active infection or a history of severe infections.
• Not recommended for individuals with a history of bone marrow suppression or low blood cell counts.
• Should not be used during pregnancy or while breastfeeding without medical advice.
• Do not take if you have liver or kidney disease.
• Avoid if you have a history of gastrointestinal issues, such as ulcerative colitis or Crohn's disease.
• Contraindicated for individuals with a known sensitivity to mercaptopurine, as azathioprine is metabolized into this substance in the body.
• Not suitable for patients with a history of pancreatitis.
• Should not be used in patients with a known deficiency of the enzyme thiopurine methyltransferase (TPMT).

The side effects of Azathioprine 50mg Tablet may include:

• Nausea and vomiting
• Loss of appetite
• Fatigue and weakness
• Increased risk of infections
• Fever
• Liver problems (e.g., hepatitis, jaundice)
• Skin rashes or itching
• Hair loss

Following are the precautions and warnings for Azathioprine 50mg Tablet:

• Do not take this medication if you are allergic to azathioprine or any of its components.
• Regular blood tests are required to monitor liver and kidney function, blood cell counts, and to assess the risk of pancreatitis.
• Azathioprine may cause bone marrow suppression, leading to decreased white blood cell, red blood cell, and platelet counts. Monitor blood counts regularly.
• Patients with a history of liver or kidney disease should use this medication with caution, as it may increase the risk of toxicity.
• Avoid live vaccines while on azathioprine treatment, as it can affect the immune response.
• Inform your doctor if you are pregnant or planning to become pregnant, as azathioprine may cause birth defects. Effective contraception is recommended during treatment.
• Breastfeeding is not recommended while taking azathioprine as it may pass into breast milk and harm the nursing infant.
• This medication may increase the risk of developing certain types of cancer, especially with long-term use. Regular medical check-ups are necessary.

Following are the drug interactions for Azathioprine 50mg Tablet:

• Concurrent use with other immunosuppressants (e.g., cyclosporine, tacrolimus) can increase the risk of serious infections and lymphoproliferative disorders.
• Azathioprine may reduce the effectiveness of live vaccines due to its immunosuppressive effects.
• The risk of myelosuppression and bone marrow suppression is increased when combined with other myelosuppressive agents, such as methotrexate or chloramphenicol.
• Allopurinol and ACE inhibitors can significantly increase azathioprine's metabolism, leading to increased toxicity.
• Warfarin's anticoagulant effect may be enhanced, requiring close monitoring of INR.
• Trimethoprim-sulfamethoxazole can decrease the metabolism of azathioprine, leading to increased blood levels and potential toxicity.
• Caution is advised with drugs that induce or inhibit CYP enzymes, as they may alter azathioprine's metabolism.

Following are the food interactions for Azathioprine 50mg Tablet:

• Alcohol consumption should be limited or avoided as it may increase the risk of liver toxicity and gastrointestinal side effects.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Azathioprine, leading to increased drug levels and potential toxicity.
• High-fiber foods like whole grains, legumes, and leafy green vegetables can reduce the absorption of Azathioprine, so it is advisable to maintain a consistent diet during treatment.
• Live vaccines and probiotics should be used with caution as Azathioprine can suppress the immune response, reducing vaccine effectiveness and potentially causing infections.
• Vitamin B6 (Pyridoxine) supplements may need adjustment as Azathioprine can interfere with its metabolism. Consult your doctor for guidance.
• It is generally recommended to maintain a balanced and healthy diet to support overall health and manage potential side effects like nausea and appetite changes.
• Always inform your healthcare provider about your dietary habits and any supplements you take to ensure safe and effective use of Azathioprine.

Azathioprine 50mg Tablets should be stored in a cool, dry area, ideally at room temperature, ensuring protection from light and moisture. It is crucial to keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. Avoid exposing the medication to extreme temperatures, such as those found in bathrooms or near heat sources like ovens or radiators, as this can impact its effectiveness. Proper disposal of unused or expired tablets is essential; do not flush them or pour them down the drain. Consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep the medication securely stored, out of the reach of children, to prevent accidental consumption.

Following are the quick tips for Azathioprine 50mg Tablet:

• Consult your doctor for personalized dosage instructions based on your medical condition.
• Take the tablet as directed by your healthcare provider, usually once or twice daily.
• Consume the tablet with a full glass of water to aid in swallowing.
• Maintain a consistent medication schedule by taking it at the same time each day.
• If you experience nausea, taking the tablet with food may help alleviate discomfort.
• Inform your doctor about all medications you're taking to prevent potential drug interactions.
• Regular blood tests may be required to monitor your body's response to the medication.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.