INDERAL 10MG TAB 50S

Propranolol is a non-selective beta-blocker, meaning it blocks both beta-1 and beta-2 adrenergic receptors in the body. Propranolol blocks beta-1 receptors in the heart, which slows down the heart rate and reduces the force of heart contractions. This lowers blood pressure and reduces the heart's workload. By blocking beta-2 receptors, it can cause narrowing of the airways (bronchoconstriction) and may also cause blood vessels to constrict. This is why it’s used cautiously in people with asthma or other respiratory conditions.

Beta-Blocker

This tablet is used to manage:

• High Blood Pressure
• Angina
• Arrhythmias
• Heart Rate Reduction

Propranolol dosage recommendations for Adults are:

• High Blood Pressure (Hypertension) - 160-640 mg daily
• Chest Pain (Angina) - 80-480 mg daily
• Heart Disorders (Obstructive Hypertrophic Cardiomyopathy) - 30-160 mg daily
• Irregular Heartbeats (Arrhythmias) - 30-240 mg daily
• Protection After Myocardial Infarction - 160 mg daily
• Migraine Prevention - 80-240 mg daily
• Tremors - 40-160 mg daily
• Anxiety Symptoms - 30-160 mg daily
• Thyroid Disorders (Thyrotoxicosis) - 30-160 mg daily
• Pheochromocytoma - 30-160 mg daily
• Prevention of Esophageal Bleeding (High Blood Pressure in the Liver) - 80-320 mg daily

In case of overdose or accidental ingestion, immediately consult your doctor or pharmacist, indicating the medication and the amount ingested. It is recommended that you take the pack and package leaflet of this medicine to the healthcare personnel.

If you miss a dose, take it as soon as you remember. If it is close to the next dose, skip the missed dose. Do not take double doses.

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

Do not take Propranolol if you:

• Are allergic (hypersensitive) to propranolol or any of the other ingredients
• Suffer from asthma, wheezing, or other breathing difficulties
• Have or have ever had heart problems, including heart failure or heart block, or have had a very slow or irregular heart rate, low blood pressure (hypotension), or poor blood circulation
• Suffer from Prinzmetal's angina (a tight, painful feeling in the chest at rest)
• Have untreated pheochromocytoma (high blood pressure due to a tumor near the kidney)
• Are on a strict fasting diet
• Have had a shock caused by heart problems or heart rhythm-related illness (sick sinus syndrome)
• Are prone to low blood sugar levels
• Are pregnant, think you may be pregnant, or are breastfeeding

The side effects of Propranalol tablets are as follows:

• Fatigue
• Dizziness
• Bradycardia
• Gastrointestinal discomfort
• Cold extremities

Here are some crucial warnings and precautions to keep in mind:

• Patients with 1st-degree heart block, compensated heart failure, diabetes mellitus, myasthenia gravis, or a history of anaphylactic reactions to allergens should use the medication with caution, as it may impact these conditions.
• Those with less severe peripheral circulatory disturbances or Wolff-Parkinson-White Syndrome should also be monitored carefully.
• Individuals undergoing surgery should avoid abrupt withdrawal of the medication, especially if they have ischaemic heart disease. Chronic therapy should not be routinely stopped before major surgery.
• The medication may mask the signs and symptoms of hypoglycaemia and hyperthyroidism, particularly tachycardia.
• It is important to use the medication cautiously in patients with renal and hepatic impairment.
• Special care should be taken for neonates, children, and elderly patients. Consult a healthcare provider before use during pregnancy and lactation.

Drug interactions with propranolol include:

• Antihypertensives (e.g., ACE inhibitors, diuretics) (may enhance the hypotensive effect)
• Calcium channel blockers (e.g., verapamil, diltiazem) (may increase the risk of bradycardia and heart block)
• CYP2D6 inhibitors (e.g., fluoxetine, paroxetine) (may increase propranolol levels)
• NSAIDs (e.g., ibuprofen) (may reduce the antihypertensive effect of propranolol)
• Antidiabetic medications (e.g., insulin, metformin) (propranolol may mask hypoglycemic symptoms)
• Digoxin (may enhance the effect of propranolol)

Store at room temperature in a tightly closed container. Dispose of unused or expired medication by returning it to a pharmacy for safe disposal.