Indomethacin (25mg) 100 Capsules

Indomethacin, a non-steroidal anti-inflammatory drug (NSAID), exerts its mechanism of action primarily by inhibiting cyclooxygenase (COX) enzymes, which are responsible for the synthesis of prostaglandins. It preferentially targets COX-1 and COX-2 enzymes, leading to a reduction in the production of prostaglandin precursors. This inhibition results in decreased inflammation, pain, and fever. Indomethacin blocks the conversion of arachidonic acid to prostaglandin H2, a crucial step in the prostaglandin synthesis pathway, thereby reducing the levels of prostaglandins that mediate pain and inflammation at the site of injury or damage.

Indomethacin

NSAID (Non-steroidal anti-inflammatory drug)

Capsule

The following are the uses of Indomethacin Capsule:

• Used for relieving pain, swelling, and inflammation caused by conditions like arthritis and gout.
• Used for treating acute pain and inflammation following surgery or injury.
• Used to reduce fever and manage pain in conditions such as headaches and muscle aches.
• Used for easing pain and stiffness in the neck, back, or joints.
• Used in the management of pain and inflammation in conditions such as tendinitis and bursitis.
• Used for providing relief in primary dysmenorrhea (painful menstruation).
• Used for reducing inflammation and discomfort in certain types of shoulder and arm pain.
• Used as a supportive therapy to alleviate pain and inflammation in various medical conditions.

In the case of an overdose of Indomethacin Capsules, individuals may experience severe gastrointestinal symptoms such as nausea, vomiting, and stomach pain. Additionally, an overdose can lead to dizziness, headaches, and in extreme cases, seizures. It is important to seek medical advice promptly if an overdose is suspected, as healthcare professionals can provide guidance and treatment to manage these symptoms effectively. Timely intervention is crucial to prevent potential complications.

In the case of a missed dose of Indomethacin Capsule, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen. It is advisable to set reminders or alarms to help you remember to take your medication on time.

To take Indomethacin Capsules, swallow the capsule whole with a full glass of water, preferably with food or milk, following the prescribed dosage instructions provided by your healthcare professional, typically taken 2 to 3 times a day, with the exact timing determined by your doctor.

Following are the conditions/situations when Indomethacin Capsule should not be used:

• Do not take if you have a history of allergic reactions to NSAIDs (non-steroidal anti-inflammatory drugs), including aspirin, or if you have experienced asthma attacks, hives, or other allergic reactions after taking these medications.
• Contraindicated in individuals with severe heart failure, as it can worsen the condition.
• Avoid using if you have recently had or are scheduled to have heart bypass surgery (coronary artery bypass graft, or CABG).
• Not suitable for individuals with a history of gastrointestinal bleeding or perforation, as it can increase the risk of these conditions.
• Should not be used by individuals with severe kidney disease or those at risk of kidney failure.
• Contraindicated in patients with severe liver impairment.
• Avoid using in the third trimester of pregnancy, as it can cause premature closure of the ductus arteriosus in the fetal heart.
• Do not give to infants younger than 6 months old, as it can increase the risk of serious side effects.
• Should not be used by individuals with a history of stroke or mini-stroke (transient ischemic attack, TIA).
• Do not take if you have a bleeding disorder or if you are taking blood-thinning medications.
• Contraindicated in patients with uncontrolled hypertension (high blood pressure).
• Avoid using if you have a history of gastrointestinal ulcers or bleeding.

The side effects of Indomethacin Capsule may include:

• Stomach pain or upset
• Nausea and vomiting
• Diarrhea
• Dizziness or vertigo
• Headache
• Drowsiness or fatigue
• Skin rash or itching
• High blood pressure

Following are the precautions and warnings for Indomethacin Capsule:

• Not suitable for individuals with a known allergy to Indomethacin or other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs).
• Patients with a history of gastrointestinal bleeding, ulcers, or other gastrointestinal issues should exercise caution and consult a healthcare provider before using this medication.
• Long-term use of Indomethacin may increase the risk of cardiovascular events such as heart attack or stroke. Regular monitoring is advised.
• Caution is advised for patients with kidney or liver disease, as the medication may need to be adjusted or avoided.
• It may cause dizziness or drowsiness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Not recommended for use during pregnancy or breastfeeding without medical advice.
• Indomethacin may cause an increase in blood pressure; patients with hypertension should be monitored regularly.

Following are the drug interactions for Indomethacin Capsule:

• Concurrent use with other NSAIDs or corticosteroids may increase gastrointestinal bleeding risk.
• Potentially dangerous interactions with angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or beta-blockers can lead to decreased kidney function and increased blood pressure.
• Indomethacin can reduce the effectiveness of diuretics, causing decreased diuretic and antihypertensive effects.
• Combining with lithium may result in increased lithium levels and toxicity.
• Anticoagulants such as warfarin may have their effects enhanced, increasing the risk of bleeding.
• Methotrexate levels may be elevated when used with Indomethacin, leading to potential toxicity.
• Probenecid can increase the concentration of Indomethacin, potentially enhancing its effects and side effects.
• Antidiabetic medications may require dosage adjustments when used with Indomethacin due to altered blood glucose control.

Following are the food interactions for Indomethacin Capsule:

• Alcohol consumption should be avoided as it can increase the risk of gastrointestinal bleeding and liver toxicity.
• Grapefruit and grapefruit juice are to be avoided as they can increase the levels of Indomethacin in the blood, leading to potential toxicity.
• Milk and dairy products may interfere with the absorption of Indomethacin, so it is advisable to separate them by at least 1-2 hours.
• Avoid high-fat meals as they can increase the absorption of Indomethacin, potentially leading to increased side effects.
• Salt substitutes containing potassium should be used cautiously as Indomethacin can increase potassium levels in the body.
• Caffeine intake should be monitored as it can increase the risk of caffeine-related side effects due to Indomethacin's potential to inhibit caffeine metabolism.
• Avoid herbal supplements like Ginkgo Biloba and garlic as they may increase bleeding risk when combined with Indomethacin.
• Consult a doctor if you regularly consume large amounts of Vitamin K-rich foods like spinach and broccoli, as Indomethacin can interfere with blood clotting.

Indomethacin Capsules should be stored in a cool, dry area away from direct sunlight and moisture. It is crucial to keep the capsules in their original packaging, ensuring the container is tightly sealed to maintain their integrity and prevent contamination. Avoid storing them in bathrooms or near heat-emitting appliances like stoves or heaters, as temperature fluctuations can impact the medication's effectiveness. Dispose of any unused or expired capsules responsibly; refrain from flushing them down the toilet or pouring them into drainage systems. Consult your pharmacist or healthcare professional for guidance on appropriate disposal methods. Always keep medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Indomethacin Capsule:

• Consult your doctor before starting the medication, especially if you have any medical conditions or allergies.
• Take the capsule as directed by your doctor, typically 2-3 times a day with food or milk to prevent stomach upset.
• Swallow the capsule whole; do not crush or chew to ensure proper absorption.
• Avoid taking antacids or other stomach-soothing medications within 2 hours of taking Indomethacin.
• Inform your doctor about all medications you're taking to prevent potential drug interactions.
• Stay hydrated and avoid excessive alcohol consumption while on this medication.
• Store the capsules in a cool, dry place, away from direct sunlight and moisture.