INFLUVIT TAB (80S)

The mechanism of action of Paracetamol 300mg and Propiphenazone 150mg in the tablet is primarily through their analgesic and antipyretic effects. Paracetamol works by inhibiting the synthesis of prostaglandins, which are involved in pain and fever signaling. It selectively blocks cyclooxygenase (COX) enzymes in the central nervous system, reducing the production of prostaglandin E2, which is responsible for mediating pain and fever responses. Propiphenazone, on the other hand, is a non-steroidal anti-inflammatory drug (NSAID) that exerts its analgesic and antipyretic effects by inhibiting both COX-1 and COX-2 enzymes. This dual inhibition reduces the production of prostaglandins and thromboxanes, thereby decreasing pain, inflammation, and fever. When combined, Paracetamol and Propiphenazone act synergistically to provide enhanced pain relief and fever reduction, making this tablet an effective treatment for various conditions requiring analgesic and antipyretic management.

Analgesic-Antipyretic Combination

Tablet

The following are the uses of Paracetamol 300mg, Propiphenazone 150mg Tablet:

• Used for relieving mild to moderate pain such as headaches, toothaches, and menstrual cramps.
• Used for reducing fever and managing symptoms of cold and flu.
• Used to alleviate discomfort from minor injuries like sprains and strains.
• Effective for managing pain and fever associated with vaccinations.
• Can be used to treat pain and inflammation caused by conditions like arthritis.
• Provides relief from body aches and pains related to muscle stiffness.
• Helps reduce discomfort and fever in children, under medical supervision.
• May be used as a post-operative pain reliever as advised by a healthcare professional.

In the case of an overdose of Paracetamol 300mg and Propiphenazone 150mg tablets, individuals may experience symptoms such as nausea, vomiting, abdominal pain, and potential liver damage. The severity of the effects depends on the amount ingested and individual factors. Prompt medical attention is necessary to manage the overdose effectively, and healthcare professionals should be contacted immediately for guidance and treatment options. Early intervention can help minimize the risks associated with an overdose of these medications.

In the case of a missed dose of Paracetamol 300mg and Propiphenazone 150mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you have missed multiple doses, consult your healthcare provider for guidance on how to safely resume your medication regimen.

To take the Paracetamol 300mg and Propiphenazone 150mg Tablet, swallow the tablet whole with a glass of water, following the prescribed dosage instructions provided by your healthcare professional, typically taken once or twice daily as directed.

Following are the conditions/situations when Paracetamol 300mg, Propiphenazone 150mg Tablet should not be taken:

• Avoid if you are allergic to paracetamol, propiphenazone, or any other similar medications.
• Do not take this medication if you have severe kidney or liver disease.
• Not suitable for individuals with inherited enzyme deficiency conditions such as glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Contraindicated in patients with a history of severe allergic reactions or asthma.
• Should not be used in patients with severe heart disease or circulatory problems.
• Avoid if you have a history of stomach bleeding or peptic ulcers.
• Not recommended for individuals with blood disorders or low blood platelet counts.
• Do not take this medication if you are currently using certain medications such as anticoagulants (blood thinners) or monoamine oxidase inhibitors (MAOIs).

The side effects of Paracetamol 300mg, Propiphenazone 150mg Tablet may include:

• Nausea and vomiting
• Stomach pain or discomfort
• Allergic reactions (such as rash, itching, swelling)
• Dizziness or lightheadedness
• Headache
• Liver damage (in rare cases, with prolonged use)
• Skin reactions (such as hives, peeling or blistering)
• Changes in blood pressure

Here are the precautions and warnings for Paracetamol 300mg, Propiphenazone 150mg Tablet:

• Avoid excessive use of this medication, as prolonged or high-dose usage may lead to liver damage.
• Patients with pre-existing liver conditions should exercise caution and consult a healthcare professional before use.
• Alcohol consumption should be minimized or avoided while taking this medication to reduce the potential risk of liver-related issues.
• Not recommended for individuals with severe kidney impairment; dosage adjustments might be necessary for those with kidney issues.
• Patients with a known allergy to paracetamol or propiphenazone should not take this medication.
• This medication may cause drowsiness or dizziness in some individuals; avoid driving or operating machinery if affected.
• Consult a doctor if symptoms persist or worsen despite taking the medication as directed.
• Keep out of reach of children and store in a cool, dry place.

Following are the drug interactions for Paracetamol 300mg, Propiphenazone 150mg Tablet:

• Paracetamol may increase the risk of liver damage when taken with other medications that are metabolized by the liver, such as certain antibiotics and anticonvulsants.
• It can interact with anticoagulants like warfarin, potentially reducing the effectiveness of the blood-thinning medication.
• Propiphenazone may enhance the effects of central nervous system depressants, including alcohol, opioids, and benzodiazepines, leading to increased sedation.
• Avoid using with other NSAIDs, as it may increase the risk of gastrointestinal bleeding and kidney problems.
• Concomitant use with other antipyretics or analgesics may lead to overdose and potential liver toxicity.
• This medication may decrease the effectiveness of certain antihypertensive drugs, requiring close monitoring of blood pressure.
• Consult a healthcare professional before taking with herbal supplements like St. John's Wort, as it may affect the metabolism of the drug.

Following are the food interactions for Paracetamol 300mg, Propiphenazone 150mg Tablet:

• Alcohol consumption should be avoided as it can increase the risk of liver damage, especially with prolonged use of paracetamol.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of the medication, potentially altering its effectiveness.
• Caffeine-rich foods and beverages like coffee, tea, and energy drinks may increase the metabolism of propiphenazone, leading to reduced effectiveness.
• Fatty foods can slow down the absorption of paracetamol, potentially delaying its pain-relieving effects.
• High-fiber foods may affect the absorption of propiphenazone, possibly reducing its bioavailability.
• Avoid excessive consumption of foods containing tyramine (aged cheeses, cured meats, fermented foods) as they can potentially interact with propiphenazone, causing elevated blood pressure.
• Vitamin K-rich foods like leafy greens may interact with the medication's blood-thinning effects, requiring monitoring in some cases.
• Spicy foods can potentially irritate the stomach and may be best avoided if you have a sensitive stomach, especially when taking pain medications.

Paracetamol 300mg, Propiphenazone 150mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent contamination. Avoid exposing the medication to extreme temperatures, such as those found in bathrooms or near heat sources, as this can impact its effectiveness. Always check the expiration date before use, and for proper disposal of unused or expired tablets, consult a pharmacist or healthcare professional rather than discarding them in household waste or flushing them down the toilet. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Paracetamol 300mg, Propiphenazone 150mg Tablet:

• Take the tablet as directed by your doctor or pharmacist.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Maintain a gap of at least 4 hours between doses.
• Avoid taking more than the recommended dose; do not take it for longer than 3 days without medical advice.
• If you have a fever, drink plenty of fluids to stay hydrated.
• Consult your doctor if symptoms persist or worsen after 3 days of treatment.
• Store the medication in a cool, dry place, away from direct sunlight.