Injectafer (100mg/2ml) 1 Vial Injection

Ceftriaxone 750mg, a third-generation cephalosporin antibiotic, exerts its bactericidal effect by disrupting the synthesis of the bacterial cell wall. It specifically targets penicillin-binding proteins (PBPs), which are essential for cross-linking peptidoglycan strands during cell wall formation. By binding to these PBPs, Ceftriaxone inhibits the final transpeptidation step, preventing the formation of a strong and stable bacterial cell wall. This interference leads to the weakening and eventual rupture of the cell wall, resulting in bacterial cell death. Ceftriaxone's broad-spectrum activity covers a wide range of Gram-positive and Gram-negative bacteria, making it effective against various infections.

Ceftriaxone 750mg

Cephalosporin antibiotic

Injection

The following are the uses of Ceftriaxone 750mg injection:

• Used for treating severe bacterial infections like pneumonia, meningitis, and skin or abdominal infections.
• Used for surgical prophylaxis to prevent infections in high-risk surgeries.
• Used for managing bone and joint infections, ensuring effective treatment.
• Used in the treatment of sexually transmitted diseases such as gonorrhea.
• Used to combat blood-related infections, providing targeted therapy.
• Used for managing certain types of hospital-acquired infections.
• Used for comprehensive coverage against a wide range of bacteria.

In the case of an overdose of Ceftriaxone 750mg injection, the severity of symptoms may vary. Common side effects can include nausea, vomiting, and diarrhea. More serious reactions might lead to allergic responses, such as skin rashes, itching, or difficulty breathing. Prompt medical intervention is necessary to manage these symptoms and prevent potential complications, ensuring the patient's well-being. It is advisable to seek medical advice if any adverse effects are experienced after the administration of this medication.

In the case of a missed dose of Ceftriaxone 750mg injection, it is important to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. However, do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may need to adjust your treatment plan. It is essential to follow the prescribed timing and frequency of doses to ensure the medication's effectiveness.

To administer Ceftriaxone 750mg injection, clean the injection site, insert the needle at a 90-degree angle, and inject the medication slowly, ensuring the entire dose is delivered, following the prescribed dosage instructions provided by your healthcare professional.

Here are the conditions or situations when Ceftriaxone 750mg injection should not be administered:

• Avoid use in patients with a known allergy to Ceftriaxone or any other cephalosporin antibiotics.
• Do not use if the patient has a history of severe hypersensitivity reactions to penicillins, as cross-reactivity may occur.
• Contraindicated in patients with jaundice or severe liver impairment.
• Should not be used in patients with a history of cholestatic jaundice/hepatic dysfunction associated with prior Ceftriaxone use.
• Not recommended for neonates if they require (or are expected to require) intravenous calcium treatment, including neonatal total parenteral nutrition (TPN), due to the risk of precipitation of ceftriaxone-calcium.
• Avoid use in premature neonates, especially those with hyperbilirubinemia or a risk of developing it, as Ceftriaxone may contribute to the development of neonatal jaundice.
• Do not administer Ceftriaxone intravenously with solutions containing calcium, such as Ringer's solution, due to the risk of precipitation.
• Should not be used in patients with a history of gallbladder or biliary tract disease, as Ceftriaxone can cause biliary sludge or gallstones.
• Contraindicated in patients with a history of Stevens-Johnson syndrome or toxic epidermal necrolysis with Ceftriaxone use.

The side effects of Ceftriaxone 750mg injection may include:

• Nausea and vomiting
• Diarrhea
• Skin rashes or itching
• Headache
• Dizziness
• Phlebitis (inflammation of the vein) at the injection site
• Increased liver enzymes
• Allergic reactions (such as hives, swelling, or difficulty breathing)

Following are the precautions and warnings for Ceftriaxone 750mg Injection:

• Avoid use in patients with known hypersensitivity to ceftriaxone, other cephalosporins, or any other components of the injection.
• Use with caution in patients with a history of severe allergies or anaphylaxis to penicillins, as cross-reactivity between penicillins and cephalosporins may occur.
• Not recommended for use in neonates due to potential risk of precipitates forming when ceftriaxone is mixed with calcium-containing solutions.
• Ceftriaxone should be used with caution in patients with liver or kidney disease, as dose adjustments may be necessary.
• It may cause gastrointestinal side effects such as diarrhea, nausea, and vomiting. Monitor for signs of Clostridium difficile-associated diarrhea.
• Prolonged use of ceftriaxone may lead to superinfection, including fungal infections. Monitoring for new infections is required.
• Ceftriaxone may occasionally cause hematologic reactions such as thrombocytopenia and leukopenia, requiring blood count monitoring during extended therapy.
• This medication can affect clotting ability, so coagulation parameters should be monitored in patients with bleeding disorders or those on anticoagulant therapy.
• False-positive results may occur in urine glucose tests; alternative testing methods should be considered.
• May interact with other medications, particularly other antibiotics and blood thinners. Always inform your healthcare provider about all medications you are taking.
• Close monitoring is necessary for patients with a history of gastrointestinal diseases like colitis, as ceftriaxone may worsen these conditions.
• Pregnant or breastfeeding women should consult a healthcare provider before using ceftriaxone to ensure safety.
• If allergic reactions (such as rash, swelling, or difficulty breathing) occur, discontinue use and seek immediate medical attention.

Following are the drug interactions for Ceftriaxone 750mg injection:

• Probenecid inhibits the renal tubular secretion of ceftriaxone, resulting in increased and prolonged blood levels.
• Concomitant use of ceftriaxone with calcium-containing IV solutions (including continuous calcium-containing infusions such as parenteral nutrition) in neonates can lead to fatal precipitation of ceftriaxone-calcium salt.
• Ceftriaxone may decrease the effectiveness of oral contraceptives, requiring additional contraceptive measures.
• Increased risk of bleeding or reduced efficacy when used with anticoagulants or thrombolytic agents.
• May affect the action of antidiabetic drugs, requiring close monitoring of blood glucose.
• The nephrotoxicity of potentially nephrotoxic drugs (e.g., aminoglycosides, loop diuretics) may be increased.
• May decrease the effectiveness of live attenuated vaccines, such as the oral polio vaccine.

Following are the food interactions for Ceftriaxone 750mg injection:

• Ceftriaxone can be administered without regard to meals, so it is generally safe to consume food before or after the injection.
• Avoid alcohol consumption during the treatment period, as it may increase the risk of liver-related side effects and interact with the medication's metabolism.
• Grapefruit and grapefruit juice should be avoided as they may interfere with the metabolism of Ceftriaxone, potentially increasing its levels in the body and the risk of adverse effects.
• Dairy products like milk, yogurt, and cheese are generally safe to consume, but if you have a known allergy to calcium or lactose intolerance, consult your doctor.
• High-fat meals may slightly delay the absorption of Ceftriaxone, but this is not considered a significant interaction.
• Avoid consuming large amounts of vitamin C supplements, as high doses may interfere with the effectiveness of Ceftriaxone.
• There is no known interaction with caffeine, but moderation is advised as excessive caffeine intake may cause nervousness and sleep disturbances.
• Stay hydrated by drinking plenty of water, as dehydration can affect the distribution and elimination of the medication.

Ceftriaxone 750mg injection should be stored in a controlled environment, specifically at room temperature between 20-25°C (68-77°F). Protect it from light and moisture by keeping it in its original packaging, ensuring the vial is tightly sealed. It is crucial to maintain the integrity of the medication by avoiding exposure to direct sunlight and extreme temperatures. Always check the expiration date before use and never use the injection if it is expired. When disposing of unused or expired Ceftriaxone, do not throw it in the trash or pour it down the drain. Instead, contact your healthcare provider or pharmacist for guidance on safe disposal methods to minimize environmental impact. Keep this medication out of children's reach to prevent accidental exposure.

Following are the quick tips for Ceftriaxone 750mg Injection:

• Administer the injection under medical supervision for optimal therapy.
• Ensure the injection is prepared and administered by trained medical professionals.
• Ceftriaxone is typically given intravenously or as an intramuscular injection.
• Follow the prescribed dosage and duration provided by your healthcare provider.
• Inform your doctor about any allergies or medical conditions before receiving the injection.
• Store the injection as directed, usually at room temperature, away from light and moisture.
• Do not use if the solution appears discolored or contains particles.
• Dispose of any unused or expired medication properly, do not flush or throw it into the trash.