INNOHEP 10000UNIT ING

INNOHEP 10000UNIT ING

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  • Manufacturer LEO PHARMACEUTICALS (PVT.) LTD.
  • Generic Name Tinzaparin

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Tinzaparin, a low-molecular-weight heparin, exerts its therapeutic effects through multiple mechanisms. Primarily, it acts as an anticoagulant by potentiating the activity of antithrombin III (AT-III), a natural inhibitor of coagulation. This potentiation results in the inhibition of factor Xa, a pivotal enzyme in the coagulation cascade, thereby suppressing both intrinsic and extrinsic pathway activation. Consequently, the conversion of prothrombin to thrombin is hindered, ultimately preventing the formation of fibrin clots. Additionally, tinzaparin exhibits a mild inhibitory effect on thrombin itself, further reinforcing its anticoagulant properties. The combined action of these mechanisms contributes to the drug's efficacy in preventing and treating thromboembolic disorders.

  • Ingredients

    Tinzaparin
  • Drug Class

    Anticoagulants

  • Dosage Form

    Injection

  • Uses

    The following are the uses of Tinzaparin Injection:

    • Used for preventing deep vein thrombosis (DVT) and blood clots in patients undergoing abdominal surgery, hip replacement surgery, or those with severely restricted mobility.
    • Used for treating DVT and pulmonary embolism (PE), effectively dissolving existing clots and preventing new ones from forming.
    • Used for managing unstable angina and heart attacks, helping to prevent further clotting and improving blood flow to the heart.
    • Used for certain types of stroke, aiding in the reduction of blood clots and improving blood circulation in the brain.
    • Used for dialysis patients to prevent clotting in the tubes and filters of the dialysis machine, ensuring efficient treatment.
    • Used for pregnant women with a history of blood clots or clotting disorders, reducing the risk of pregnancy-related clotting complications.
    • Used for patients with inherited clotting disorders, such as antithrombin III deficiency, to control and prevent excessive blood clotting.
  • In case of Overdose

    In the case of an overdose of Tinzaparin Injection, it is important to recognize the potential risks and take appropriate action. Symptoms may include excessive bleeding, easy bruising, or nosebleeds. If an overdose is suspected, immediate medical advice should be sought. Prompt treatment can help manage the effects of the overdose and may involve administering an antidote or providing supportive care to minimize complications. It is crucial to act swiftly and consult healthcare professionals for guidance and appropriate medical intervention.

  • Missed Dose

    In the case of a missed dose of Tinzaparin Injection, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of bleeding or other side effects. If you miss several doses, contact your healthcare provider for guidance on how to safely resume your medication. It is essential to maintain a consistent dosing routine for the best therapeutic effect.

  • How To Use

    To administer the Tinzaparin Injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and inject the medication under the skin, following the prescribed dosage and frequency provided by your healthcare professional.

  • When Not to Use

    Following are the conditions when Tinzaparin Injection should not be used:

    • Should not be administered to patients with a known allergy to tinzaparin, heparin, or any other ingredients in the injection.
    • Contraindicated in individuals with active or recent severe bleeding issues, such as gastrointestinal bleeding or bleeding in the brain.
    • Not recommended for patients with a low platelet count (thrombocytopenia) or conditions that increase the risk of bleeding.
    • Should not be used in patients with severe uncontrolled high blood pressure (hypertension).
    • Contraindicated in individuals with confirmed or suspected serious bacterial infections of the heart (endocarditis).
    • Not suitable for patients with a history of heparin-induced low platelet count (heparin-induced thrombocytopenia).
    • Should not be used in individuals with severe liver disease or active liver disorders.
  • Side Effects

    The side effects of Tinzaparin Injection may include:

    • Bleeding or bruising
    • Allergic reactions such as rash, itching, or hives
    • Pain, redness, or swelling at the injection site
    • Increased risk of bleeding, including gastrointestinal bleeding
    • Thrombocytopenia (low platelet count)
    • Transient thrombocytopenia (temporary low platelet count)
    • Heparin-induced thrombocytopenia (a serious immune response)
    • Renal impairment (kidney problems)
  • Precautions & Warnings

    Following are the precautions and warnings for Tinzaparin Injection:

    • Tinzaparin should not be used in patients with known hypersensitivity to tinzaparin or other low-molecular-weight heparins, heparin, or any of its excipients.
    • It must be used with caution in patients with a history of bleeding disorders, peptic ulcers, or those on concurrent medications that increase bleeding risk.
    • Patients undergoing spinal anesthesia or lumbar puncture should be closely monitored for signs of spinal hematoma, a rare but serious complication.
    • Tinzaparin should be used with caution in the elderly and those with renal impairment, as dosage adjustments may be necessary.
    • Patients should be monitored regularly for signs of thrombocytopenia, a decrease in platelet count that can lead to abnormal bleeding.
    • Not recommended for use in children due to limited data on safety and efficacy.
    • Pregnant and breastfeeding women should use Tinzaparin only if the potential benefits outweigh the risks, and under strict medical supervision.
  • Drug Interactions

    Following are the drug interactions for Tinzaparin Injection:

    • Anticoagulants like warfarin or other heparin-based drugs can increase the risk of bleeding when used with Tinzaparin, and regular monitoring is necessary.
    • Aspirin and other antiplatelet agents may further enhance the anticoagulant effect, requiring close supervision.
    • Nonsteroidal anti-inflammatory drugs (NSAIDs) might elevate the risk of gastrointestinal bleeding when combined with Tinzaparin.
    • Thrombolytic agents, such as alteplase or streptokinase, could lead to a higher bleeding tendency and should be used with caution.
    • Certain antibiotics, like ceftriaxone or clarithromycin, may increase the anticoagulant effect of Tinzaparin.
    • Tinzaparin can interact with drugs affecting renal function, such as ACE inhibitors or diuretics, potentially altering its clearance.
    • Medications that affect platelet function, like clopidogrel, might require dose adjustments when used concurrently with Tinzaparin.
  • Food Interactions

    Following are the food interactions to consider with Tinzaparin Injection:

    • Avoid excessive alcohol consumption as it can increase the risk of bleeding complications when combined with Tinzaparin.
    • Grapefruit and grapefruit juice should be consumed with caution as they may affect the blood levels of Tinzaparin, potentially altering its anticoagulant effect.
    • Maintain a consistent diet with stable vitamin K levels, as sudden changes can impact the effectiveness of Tinzaparin. Vitamin K-rich foods include leafy green vegetables, broccoli, and liver.
    • Inform your healthcare provider if you have a significant change in diet or start taking dietary supplements, especially those with anticoagulant properties.
    • Avoid high-sodium foods, as Tinzaparin may increase sodium levels in the body.
    • No specific food restrictions are typically required with Tinzaparin, but individual dietary considerations may apply.
    • Always follow the dietary advice provided by your healthcare team while using Tinzaparin Injection.
  • Storage/Disposal

    Tinzaparin Injection should be stored and disposed of with utmost care to ensure safety and maintain its integrity. Store the injection at room temperature, between 68°F and 77°F (20°C and 25°C), in a cool and dry place, away from direct sunlight, moisture, and heat. Keep the injection in its original packaging, tightly sealed, to prevent contamination and maintain its sterility. Do not freeze the injection as it may affect its potency. Always check the expiration date, and if the injection has passed its expiry, do not use it and follow proper disposal methods. Dispose of unused or expired Tinzaparin Injection responsibly by returning it to a pharmacy or healthcare facility for safe disposal, and avoid flushing it down the toilet or pouring it into drains to prevent environmental contamination. Keep all medications out of the reach of children and pets to prevent accidental exposure.

  • Quick Tips, if any

    Following are the quick tips for Tinzaparin Injection:

    • Follow the dosage instructions provided by your doctor for effective treatment.
    • Administer the injection as directed; typically given once daily or as prescribed.
    • Ensure the injection is given subcutaneously (under the skin) at the recommended site.
    • Rotate injection sites to minimize discomfort and bruising.
    • Do not inject into areas with skin changes or irritation.
    • Dispose of used needles and syringes safely in a puncture-proof container.
    • Regularly monitor your blood work as advised by your healthcare provider.

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