Inocef (2000mg) 1 Vial Injection

Ceftriaxone and Sulbactam Injection is a combination antibiotic that exerts its bactericidal effect through two primary mechanisms. Ceftriaxone, a third-generation cephalosporin, inhibits the synthesis of the bacterial cell wall by binding to essential penicillin-binding proteins (PBPs), disrupting peptidoglycan synthesis, and leading to cell lysis. This action is particularly effective against a wide range of Gram-positive and Gram-negative bacteria. Sulbactam, a beta-lactamase inhibitor, protects ceftriaxone from degradation by inhibiting bacterial beta-lactamase enzymes, which are responsible for antibiotic resistance. By inactivating these enzymes, sulbactam enhances the effectiveness of ceftriaxone against beta-lactamase-producing bacteria, broadening the spectrum of activity and ensuring potent antibacterial action.

Ceftriaxone 1000mg, Sulbactam 1000mg

Cephalosporin/Penicillin combination

Injection

The following are the uses of Ceftriaxone 1000mg, Sulbactam 1000mg Injection:

• Used for treating severe bacterial infections like pneumonia, skin and soft tissue infections, and bone and joint infections.
• Used for managing abdominal infections, including peritonitis and intra-abdominal abscesses.
• Used for controlling infections in the pelvic region, such as pelvic inflammatory disease.
• Used for combating bacterial meningitis, ensuring effective treatment.
• Used for surgical prophylaxis to prevent infections during high-risk procedures.
• Used for treating hospital-acquired infections caused by resistant bacteria.
• Used for providing broad-spectrum coverage in critically ill patients.

In the case of an overdose of Ceftriaxone 1000mg and Sulbactam 1000mg Injection, the patient may experience gastrointestinal symptoms such as nausea, vomiting, and diarrhea. Additionally, there is a risk of increased antibiotic-related side effects, including skin rashes, allergic reactions, and potential changes in liver function. Prompt medical assessment is necessary to manage these symptoms and ensure appropriate supportive care is provided to the patient.

In the case of a missed dose of Ceftriaxone 1000mg and Sulbactam 1000mg Injection, it is recommended to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. It is important not to double the dose to make up for a missed one. If you have missed multiple doses, contact your healthcare provider for guidance on how to resume the medication safely. Do not administer the medication if the time since the missed dose is close to the next scheduled dose to avoid any potential side effects.

To administer Ceftriaxone 1000mg and Sulbactam 1000mg Injection, it should be given by a healthcare professional through a slow intravenous injection over 2 to 4 minutes or as a slow infusion, ensuring the medication is prepared and administered as directed by the prescribing doctor, following the recommended dosage and administration guidelines provided by the manufacturer.

Following are the conditions/situations when Ceftriaxone 1000mg and Sulbactam 1000mg Injection should not be used:

• Do not use if you have a known allergy to Ceftriaxone, Sulbactam, or any other beta-lactam antibiotics.
• Contraindicated in patients with a history of severe allergic reactions to penicillins.
• Should not be used in patients with a history of cholestatic jaundice/hepatic dysfunction associated with prior Ceftriaxone use.
• Not recommended for individuals with severe renal impairment (kidney disease) without dialysis.
• Avoid using in newborns with hyperbilirubinemia or preterm infants.
• Do not administer if the solution is discolored or contains particles.

The side effects of Ceftriaxone 1000mg, Sulbactam 1000mg Injection may include:

• Diarrhea
• Nausea and vomiting
• Skin rash or itching
• Headache
• Dizziness
• Injection site reactions (pain, swelling, or redness)
• Allergic reactions (hives, difficulty breathing, swelling of the face/lips/tongue)
• Increased liver enzymes

Following are the precautions and warnings for Ceftriaxone 1000mg, Sulbactam 1000mg Injection:

• Not recommended for patients with a history of severe allergic reactions to penicillins or cephalosporins. Cross-sensitivity may occur.
• Should be used with caution in patients with kidney or liver impairment as dosage adjustments may be necessary.
• Prolonged use may lead to the overgrowth of non-susceptible organisms, including fungi. Regularly monitor patients for superinfection.
• Ensure adequate hydration during treatment, especially in patients with reduced kidney function.
• Ceftriaxone can displace bilirubin from its binding to serum albumin, leading to a risk of bilirubin encephalopathy in neonates, especially premature infants. Monitor bilirubin levels closely.
• Sulbactam may cause false-positive results in certain urine glucose tests. Consider using an alternative method for monitoring glucose levels.
• Not recommended for use in neonates, especially premature infants, due to the risk of bilirubin displacement and potential brain damage.
• Patients with a history of gastrointestinal diseases, particularly colitis, should be closely monitored for possible recurrence during and after treatment.

Following are the drug interactions for Ceftriaxone 1000mg, Sulbactam 1000mg Injection:

• Probenecid may reduce the elimination of Ceftriaxone, leading to increased serum levels.
• Ceftriaxone can displace bilirubin from albumin, increasing the risk of hyperbilirubinemia in neonates. Avoid concomitant use with calcium-containing IV solutions, including continuous calcium-containing infusions such as parenteral nutrition, due to the risk of precipitation.
• Sulbactam may reduce the efficacy of oral contraceptives, requiring additional contraceptive measures.
• Concomitant use with anticoagulants like warfarin may increase the risk of bleeding.
• The antibiotic may reduce the effectiveness of oral typhoid vaccine and live attenuated polio vaccine.
• Ceftriaxone can falsely elevate urine glucose tests with copper reduction methods.
• Caution is advised with concurrent use of loop diuretics, as it may increase the risk of nephrotoxicity.

Following are the food interactions for Ceftriaxone 1000mg, Sulbactam 1000mg Injection:

• Avoid alcohol consumption during the treatment period as it may increase the risk of gastrointestinal side effects and reduce the effectiveness of the medication.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the absorption and metabolism of Ceftriaxone, potentially altering its effectiveness.
• Avoid high-fat meals as they can delay the absorption of Ceftriaxone, leading to reduced antibiotic levels in the blood.
• Maintain adequate hydration and ensure a balanced diet to support overall health and aid in the recovery process during antibiotic therapy.
• Avoid consuming large amounts of calcium-rich foods or supplements, as they may interact with Ceftriaxone, reducing its absorption.
• Follow any dietary instructions provided by your healthcare professional, especially if you have specific dietary restrictions or medical conditions.
• No significant food interactions have been reported with Sulbactam, but maintaining a healthy diet is recommended for overall well-being during treatment.

Ceftriaxone 1000mg and Sulbactam 1000mg Injection should be stored in a cool, controlled environment, preferably between 68°F and 77°F (20°C and 25°C), with brief excursions permitted between 59°F and 86°F (15°C and 30°C). Protect the injection from light and moisture by keeping it in its original packaging. Do not freeze the medication. Always check the expiration date before use and discard any expired or unused injections according to local regulations and guidelines. When disposing of the medication, do not throw it into the trash or pour it down the drain; instead, contact a healthcare professional or pharmacist for guidance on safe disposal methods. Keep this medication securely stored, out of the reach of children and pets, to prevent accidental ingestion.

Following are the quick tips for Ceftriaxone 1000mg, Sulbactam 1000mg Injection:

• Administer the injection under medical supervision; do not self-inject.
• Ensure the injection is prepared and administered by a trained healthcare professional.
• Inform your doctor about allergies or medical conditions before receiving the injection.
• Stay well-hydrated before and after the injection to aid in medication distribution.
• Avoid driving or operating machinery until you know how the medication affects you.
• Store the injection as directed by your pharmacist, usually at room temperature.
• Do not reuse or share needles; dispose of them safely after use.