Inosita Plus XR (50/1000mg) 14 Tablets

Sitagliptin works by inhibiting the breakdown of incretins, hormones that regulate blood sugar levels. By keeping these hormones in the bloodstream longer, insulin production is stimulated only when blood sugar levels are elevated, effectively reducing blood sugar levels in patients with type 2 diabetes mellitus. Metformin is a drug that belongs to the biguanide class, and it works by reducing glucose production in the liver and increasing glucose absorption by skeletal muscles. Unlike other drugs for managing type 2 diabetes, Metformin does not increase insulin secretion from the pancreas. This feature helps reduce the excessive workload on the pancreas, which is particularly beneficial for those whose pancreas is producing less insulin or whose bodies are resistant to insulin effects.

Biguanide, DPP-4 Inhibitor

Unveiling its multifaceted uses and transformative applications as follows:

• Sitagliptin 50mg is used for type 2 diabetes to control blood sugar levels.
• Metformin HCL 1000mg is an anti-diabetic medication that helps lower high blood sugar levels in people with type 2 diabetes.
• Both drugs are to be taken orally and can be used in combination for better blood sugar control.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For Sitagliptin 50mg, the recommended dosage is one tablet per day.
• For Metformin HCL 1000mg, the recommended dosage is two tablets per day.

An overdose of sitagliptin and metformin may result in unpleasant side effects such as nausea, vomiting, dizziness, and abnormally low blood sugar levels. If you suspect someone has experienced an overdose of these medications, it is crucial to seek medical attention immediately. The treatment for such an overdose may involve several steps. The first step may involve inducing vomiting to expel the ingested substances from the stomach, reducing their absorption. In addition, oral activated charcoal may be administered to bind to and neutralize the drugs in the digestive system, minimizing their absorption into the bloodstream. Intensive monitoring of vital signs and blood chemistry is essential to evaluate the patient's overall health. This includes monitoring blood sugar levels to determine whether corrective measures, such as supplemental glucose, are needed to manage abnormal glucose levels. Additionally, tests may be performed to evaluate kidney function and monitor potential harm to internal organs. To minimize adverse effects on vital organs, it is necessary to restore proper fluid hydration and electrolyte balance. Intravenous fluids may be administered to maintain adequate fluid levels and optimize kidney function. Extended monitoring and observation are typically recommended due to the long elimination half-life of metformin. This close medical supervision allows caregivers to monitor the patient's recovery and ensure that vital signs and blood chemistry values stabilize. The need for further intervention will be determined based on the individual's response to initial treatment and the severity of the overdose.

If you have missed a dose of your medication, it is critical to take it as soon as possible unless it is almost time for your next dose. In this case, it is best to skip the missed dose and resume your regular medication schedule. It is always recommended to seek professional advice from your healthcare provider before adjusting your medication schedule to individualize your care. They may provide you with special instructions or precautions based on your health condition and the specific medication you are taking.

When taking Sitagliptin 50mg and Metformin HCL 1000mg, ensure you follow your doctor's instructions carefully and consult with them if you have any questions. For Sitagliptin 50mg, the tablet should be taken with food, preferably at the same time each day, to maintain consistent drug levels in the bloodstream. It should be swallowed whole with water and can be taken with or without food. Do not crush or chew the tablet before consuming it. The dosage and frequency of consumption will depend on your prescription and individual medical condition. Metformin HCL 1000mg, typically needs to be taken twice a day, once before breakfast and once before dinner. It is essential to maintain consistency in taking this medication to achieve the best results. Extended-release tablets of Metformin should be swallowed whole, not crushed, chewed, opened, split, or broken. It is best to take them with a full glass of water. Remember, it is vital to follow your doctor's exact dosage instructions and direct any questions or concerns to a healthcare professional.

Discerning instances where this medication may not be appropriate:

• Consult a medical professional for advice on medications.
• Allergy alert

• Hypoglycemia not controlled

• Risk of hypoglycemia

• Drug interactions

Unraveling the side effects lurking behind this medications are as follows:

• Upper respiratory tract infection
• Headache
• Diarrhea
• Nausea
• Vomiting
• Abdominal pain
• Weakness
• Metallic taste
• Loss of appetite
• Weight loss
• Thirst
• Increased urination

Here are the crucial warnings and precautions for this medication:

• Patients with congestive heart failure (CHF) and those exposed to stress, such as infection, fever, trauma, or surgery, should use this medication with caution.
• It is not intended for the treatment of diabetic ketoacidosis or type 1 diabetes mellitus.
• Renal impairment, particularly with a glomerular filtration rate (GFR) between 30-45 mL/min, requires careful monitoring.
• The safety of this medication during pregnancy has not been well established; it should be used only if recommended by a healthcare provider.

Drug interactions with metformin and sitagliptin include:

• Insulin and other antidiabetic agents (e.g., sulfonylureas) (may increase risk of hypoglycemia)
• Renal impairment (may require dose adjustments)
• CYP3A4 inhibitors (e.g., ketoconazole) (may increase sitagliptin levels)
• CYP3A4 inducers (e.g., rifampin) (may decrease sitagliptin levels)
• NSAIDs (e.g., ibuprofen) (may increase risk of renal impairment)
• Alcohol (may enhance effects on blood glucose levels)
• Metformin and sitagliptin generally have minimal interaction with other medications, but individual patient scenarios should always be reviewed for potential interactions.

To store these medications, one should keep them in their original containers and keep them tightly closed to prevent contamination or spillage. These containers should be kept in a cool, dry place and away from direct heat, light, or humidity. Specifically, bathrooms, near sinks, or other humid environments should be avoided as they are not ideal conditions. Ideally, these medications should be stored at room temperature, unless the medication label specifies otherwise. It is also important to check the expiration date on the medication packaging and discard the medication if it has expired. Proper medication storage minimizes the risk of the medication losing its effectiveness over time.It is recommended to consult a healthcare provider or read the accompanying medication guide for any specific storage instructions. Additionally, these medications should be kept securely and safely, away from anyone who might misuse them, particularly if they are harmful or addictive.