INTEGRILIN 20MG/10ML INJ

Eptifibatide, a medication administered intravenously, acts as a potent and reversible antagonist of the platelet glycoprotein IIb/IIIa (GPIIb/IIIa) receptor. By binding specifically to this receptor, eptifibatide inhibits the final common pathway of platelet aggregation. When activated, the GPIIb/IIIa receptor facilitates the binding of fibrinogen and von Willebrand factor to platelets, leading to platelet aggregation and thrombus formation. Eptifibatide's mechanism involves mimicking the structure of certain amino acid sequences found in proteins involved in platelet aggregation, allowing it to competitively bind to the GPIIb/IIIa receptor, thereby blocking the binding of fibrinogen and preventing platelet aggregation. This action helps prevent the formation of new thrombi and the growth of existing ones, making it particularly useful in acute coronary syndrome and percutaneous coronary intervention settings.

Eptifibatide 20MG

Antiplatelet agent

Injection

The following are the uses of Eptifibatide 20MG Injection:

• Used for preventing blood clots in patients with unstable angina or those undergoing angioplasty.
• Used for managing patients with acute coronary syndrome to reduce the risk of heart attacks.
• Used for improving blood flow in patients with severe cardiovascular conditions.
• Used for short-term treatment to prevent platelets from sticking together.
• Used for patients with certain clotting disorders to manage their condition effectively.
• Used for reducing complications during cardiac procedures.
• Used for stabilizing patients after a heart attack.

In the case of an overdose of Eptifibatide 20MG Injection, it is important to act swiftly. Symptoms may include prolonged bleeding, hematoma formation, or severe hypotension. Seek medical assistance immediately and inform healthcare professionals about the overdose. They will likely monitor vital signs, provide supportive care, and manage any bleeding complications. Prompt action is crucial to ensure the best possible outcome.

In the case of a missed dose of Eptifibatide 20MG Injection, it is important to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. However, do not double the dose to make up for the missed one. If you have missed multiple doses, consult your healthcare provider for guidance on how to safely resume the medication and ensure optimal treatment.

To administer Eptifibatide 20MG Injection, ensure the injection is at room temperature, clean the injection site with an alcohol wipe, and carefully inject the entire content of the vial subcutaneously, following the instructions provided by your healthcare professional.

Following are the conditions/situations when Eptifibatide 20MG Injection should not be used:

• Should not be used in individuals with a known allergy or hypersensitivity to Eptifibatide or any of its components, including arginine and glycine.
• Contraindicated in patients with active bleeding or bleeding disorders, as it can increase the risk of bleeding.
• Not recommended for patients with recent (within 6 weeks) major surgery, trauma, or stroke, as it may worsen bleeding risks.
• Should be avoided in individuals with severe kidney disease or those on dialysis, as dosage adjustments may not be sufficient to ensure safety.
• Contraindicated in patients with a history of stroke or transient ischemic attack (TIA) within the past 30 days.
• Not suitable for patients with severe high blood pressure that is not controlled.
• Should not be used in patients with intracranial or intraspinal neoplasm, arteriovenous malformation, or aneurysm, as it may increase the risk of bleeding in these areas.

The side effects of Eptifibatide 20MG Injection may include:

• Bleeding
• Bruising
• Anemia
• Thrombocytopenia (low platelet count)
• Nausea and vomiting
• Fever
• Hypotension (low blood pressure)
• Back pain

Following are the precautions and warnings for Eptifibatide 20MG Injection:

• This medication is intended for hospital use only and should be administered by trained medical professionals.
• Patients with a history of bleeding disorders, recent major surgery, or trauma should be monitored closely as Eptifibatide can increase the risk of bleeding.
• It is crucial to monitor platelet counts regularly during treatment, and if significant thrombocytopenia occurs, the medication should be discontinued.
• Not recommended for patients with severe liver disease, as it may lead to impaired clearance of the drug.
• Elderly patients may be more susceptible to bleeding complications, so careful monitoring is essential.
• Should not be used in patients with active bleeding or a history of stroke, as it can increase the risk of intracranial hemorrhage.
• Pregnant and breastfeeding women should only use this medication if the potential benefits outweigh the risks, as its safety during pregnancy and lactation is not fully established.
• Always inform your doctor about any other medications you are taking to avoid potential drug interactions.

Following are the drug interactions for Eptifibatide 20MG Injection:

• Avoid use with other antiplatelet agents like aspirin or anticoagulants, as it may increase the risk of bleeding.
• Concomitant use with thrombolytic agents can elevate bleeding risks.
• Platelet aggregation inhibitors such as clopidogrel or ticagrelor may enhance the antiplatelet effect of eptifibatide.
• NSAIDs (e.g., ibuprofen, naproxen) can increase the risk of gastrointestinal bleeding when used with eptifibatide.
• Thienopyridines (e.g., ticlopidine, prasugrel) can prolong the antiplatelet effect, requiring careful monitoring.
• Certain herbal supplements like garlic, ginkgo biloba, or ginseng may intensify the antiplatelet activity.
• Heparin, a common anticoagulant, should be used cautiously as it can further increase bleeding tendencies.
• The combination with glycoprotein IIb/IIIa inhibitors should be avoided due to potential additive effects and increased bleeding risks.

Following are the food interactions for Eptifibatide 20MG Injection:

• Avoid consuming alcohol during treatment as it can increase the risk of bleeding complications.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of the medication, potentially altering its effectiveness.
• Avoid foods rich in vitamin K like spinach, kale, and broccoli, as they can interfere with the medication's anticoagulant effect.
• High-fat meals can potentially delay the absorption of Eptifibatide, so it is advisable to avoid fatty foods before and after medication administration.
• Garlic, ginger, and ginkgo biloba supplements may increase the risk of bleeding when taken alongside Eptifibatide.
• Consult your healthcare provider before consuming herbal teas or supplements to ensure they won't interact with the medication.
• Avoid excessive salt intake, as it can counteract the beneficial effects of Eptifibatide on blood pressure.
• Always follow the dietary recommendations provided by your doctor to ensure the best outcomes during treatment.

Eptifibatide 20MG Injection should be stored in a controlled room temperature environment, typically between 20°C and 25°C (68°F to 77°F). Protect the injection from light and moisture by keeping it in its original packaging until ready for use. It is crucial to ensure that the medication is stored in a secure location, out of the reach of children and pets, to prevent accidental exposure. Do not freeze the injection as it may affect its potency. When disposing of any unused or expired Eptifibatide, do not throw it into the trash or pour it down the drain. Contact your healthcare provider or pharmacist for guidance on proper disposal methods to ensure environmental safety.

Following are the quick tips for Eptifibatide 20MG Injection:

• Ensure the injection is administered by a trained healthcare professional.
• Verify the medication label for accurate dosage and expiration date before use.
• Eptifibatide is typically given as an intravenous (IV) infusion over a specified period.
• Follow the prescribed infusion rate and duration as directed by your doctor.
• Report any signs of allergic reactions or unusual side effects to your healthcare provider immediately.
• Do not reuse or share needles/syringes; dispose of them safely after use.
• Store the injection as directed, usually at room temperature, away from light and moisture.
• Keep a record of your medication schedule to track your treatment progress.