IRESSA 100MG TAB (10S)

Gefitinib 100MG Tablet, a selective epidermal growth factor receptor (EGFR) inhibitor, exerts its action by specifically targeting and binding to the ATP-binding site of the EGFR tyrosine kinase domain. This binding inhibits the autophosphorylation of EGFR, thereby disrupting downstream signaling pathways such as the RAS/RAF/MAPK cascade and the PI3K/AKT pathway. By blocking these signaling pathways, Gefitinib inhibits cellular proliferation, induces apoptosis in tumor cells, and suppresses angiogenesis. It demonstrates particular effectiveness in tumors harboring specific EGFR mutations, where it can lead to tumor regression and improved clinical outcomes.

Gefitinib 100MG

EGFR (epidermal growth factor receptor) inhibitor.

Tablet

The following are the uses of Gefitinib 100MG Tablet:

• Used for treating non-small cell lung cancer with specific epidermal growth factor receptor (EGFR) mutations.
• Used for inhibiting the growth and spread of cancer cells with EGFR mutations.
• Used to improve survival rates and quality of life in patients with advanced NSCLC.
• Used as a targeted therapy, blocking the signals that tell cancer cells to grow and divide.
• Used in cases where cancer has not responded to other treatments or has returned.
• Used to manage symptoms and extend the time between cancer progression.
• Used under the guidance of a medical oncologist who determines the appropriate dosage and duration.
• Used as part of a comprehensive cancer treatment plan, often in combination with other therapies.

In the case of an overdose of Gefitinib 100MG Tablet, it is important to recognize the potential risks and take prompt action. Overdosing may lead to severe side effects such as skin reactions, diarrhea, and respiratory issues. Seek medical assistance immediately if you suspect an overdose. Treatment options may include supportive care and monitoring of vital signs. Timely intervention can help manage and minimize the impact of an overdose.

In the case of a missed dose of Gefitinib 100MG Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, it is recommended to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is advisable to set a reminder or use a pill organizer to help you remember to take your medication at the same time each day to maintain consistency.

To take Gefitinib 100MG Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, as directed by your healthcare professional.

Here are the conditions or situations when Gefitinib 100MG Tablet should not be used:

• Not suitable for patients with a known hypersensitivity or allergy to Gefitinib or any of its excipients.
• Contraindicated in pregnant women as it can cause harm to the developing fetus.
• Avoid use in breastfeeding women as it may pass into breast milk and harm the nursing infant.
• Should not be used in patients with severe liver impairment or liver disease.
• Not recommended for patients with interstitial lung disease or those who have a history of it.
• Avoid use in patients with severe or uncontrolled infections, as it may mask the signs of infection.
• Not suitable for individuals with a history of severe skin reactions to similar medications.
• Should not be used in patients with rare hereditary problems of galactose intolerance, severe lactase deficiency, or glucose-galactose malabsorption.

The side effects of Gefitinib 100MG Tablet may include:

• Skin rash
• Diarrhea
• Nausea and vomiting
• Dry skin or acne
• Fatigue and weakness
• Loss of appetite
• Mouth sores or inflammation

Following are the precautions and warnings for Gefitinib 100MG Tablet:

• This medication is not recommended for individuals with a known hypersensitivity or allergy to Gefitinib or any of its excipients.
• Patients with a history of liver disease should be closely monitored, as Gefitinib can cause liver function abnormalities. Regular liver function tests are advised.
• Gefitinib may cause interstitial lung disease, so patients must report any respiratory symptoms like cough or shortness of breath immediately.
• It may cause eye disorders; patients should report any visual disturbances or eye irritation. Regular eye examinations are recommended.
• Not recommended for pregnant women as it may cause fetal harm. Effective contraception is necessary while taking this medication.
• Breastfeeding should be avoided during treatment and for a period after, as advised by the healthcare professional.
• Elderly patients may be more susceptible to side effects; dosage adjustments might be required.

Following are the drug interactions for Gefitinib 100MG Tablet:

• Phenytoin, carbamazepine, rifampicin, and phenobarbital may decrease the effectiveness of gefitinib by increasing its metabolism.
• Gefitinib can increase the blood levels of warfarin, potentially leading to an increased risk of bleeding.
• Grapefruit juice should be avoided as it can increase gefitinib levels in the body.
• Caution is advised with St. John's Wort as it may reduce gefitinib concentrations.
• Antacids containing aluminum or magnesium can decrease the absorption of gefitinib; separate administration by at least 2 hours.
• Proton pump inhibitors (PPIs) like omeprazole can reduce gefitinib exposure; consider using an alternative acid-reducing agent.
• The effectiveness of gefitinib may be reduced by ketoconazole and other strong CYP3A4 inhibitors.
• CYP3A4 inducers like dexamethasone may decrease gefitinib levels and should be used with caution.

Following are the food interactions for Gefitinib 100MG Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can lead to increased blood levels of Gefitinib, potentially causing toxicity.
• Alcohol intake is not recommended with this medication as it may enhance the risk of liver-related side effects.
• Avoid high-fat meals as they can decrease the absorption of Gefitinib, reducing its effectiveness.
• Gefitinib should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal.
• Avoid consuming large amounts of black pepper, as it may interfere with the metabolism of Gefitinib.
• Limit the intake of Seville oranges and starfruit as they may also affect the drug's metabolism.
• Be cautious with the use of St. John's Wort as it can reduce the effectiveness of Gefitinib.
• Consult your healthcare provider for personalized advice on diet and drug interactions.

Gefitinib 100MG Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area. Keep the tablets in their original container, tightly sealed, to maintain their integrity and protect them from moisture and light. Ensure the storage area is away from direct sunlight, heat sources like radiators, and moisture-prone areas like bathrooms, as these conditions can degrade the medication. Regularly check the expiration date on the packaging, and safely dispose of any expired or unused tablets. Do not flush the medication down the toilet or sink; instead, consult your pharmacist or local waste disposal guidelines for the proper method of disposal. Always keep medications out of the reach of children to prevent accidental consumption.

Following are the quick tips for Gefitinib 100MG Tablet:

• Take the tablet as directed by your doctor, typically once daily.
• Swallow the tablet whole with a glass of water; do not crush or chew.
• Take Gefitinib on an empty stomach, at least 1 hour before or 2 hours after a meal.
• Maintain a consistent schedule; take it at the same time each day.
• Do not miss doses; if you forget, take it as soon as you remember, unless it's close to the next dose.
• Inform your doctor about all medications you're taking to avoid potential interactions.
• Regularly monitor your health and report any unusual symptoms to your healthcare provider.